Hsuan-Wei Huang scite author profile

Background: Cobra venom consists of diverse toxin homologues important for prey capture through variable levels of gene duplication. Results: Comparative structural and cellular investigations revealed sensitivity of toxin homologues for extra-and intracellular targets via sulfated glycoconjugates. Conclusion: Variation in positively charged and hydrophobic domains in CTX homologues altered their target specificities and endocytosis. Significance: We provide a rationale for toxin homologues at cellular level to gain an evolutionary advantage.

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Hsuan-Wei Huang

Cobra venom proteome and glycome determined from individual snakes of Naja atra reveal medically important dynamic range and systematic geographic variation

Endocytotic Routes of Cobra Cardiotoxins Depend on Spatial Distribution of Positively Charged and Hydrophobic Domains to Target Distinct Types of Sulfated Glycoconjugates on Cell Surface

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