Vascular Endothelial Growth Factor and Transforming Growth Factor‐α and ‐β1 Are Released From Human Cultured Gingival Epithelial Sheets

Momose, Manabu; Murata, Masashi; Kato, Yumi; Yamazaki, Kazushisa; Shinohara, Chikara; Yoshie, Hiromasa

doi:10.1902/jop.2002.73.7.748

Cited by 21 publications

(17 citation statements)

References 29 publications

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“…93 Several studies have indicated that TGF-b is able to induce keratinocytes to produce VEGF gene expression. 59,97 Tian et al 93 found that TGF-b increased and reached a peak on day 3 in the silver nanoparticle-treated animals and may explain why significantly higher VEGF mRNA levels were maintained in the early stage of wound healing. 93 Tian et al 93 concluded that silver nanoparticles can modulate local and systemic inflammatory response following burn injury by cytokine modulation (Table 3).…”

Section: Silver Nanoparticles Suppress Both Local and Systemic Inflammentioning

confidence: 98%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

175

110

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Nanotechnology is on the threshold of providing a host of new materials and approaches, revolutionizing the medical and pharmaceutical fields. Several areas of medical care are already profiting from the advantage that nanotechnology offers. Recently, silver nanoparticles are attracting interest for a clinical application because of its potential biological properties such as antibacterial activity, anti-inflammatory effects, and wound healing efficacy, which could be exploited in developing better dressings for wounds and ulcers. This article reviews the role of silver nanoparticles in wound healing.

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Section: Silver Nanoparticles Suppress Both Local and Systemic Inflammentioning

confidence: 98%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

175

110

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“…It consists in the formation of new capillaries due to the budding of endothelial cells [19][20][21][22][23][24][25][26][27]. This process involves epithelial cell division, selective degradation of vascular basement membranes and endothelial cell migration [19][20][21][22][23][24][25][26][27]. Inflamed tissues tend to increase the inflammatory mediators expression, which in turn may promote angiogenesis [25].…”

Section: Introductionmentioning

confidence: 99%

“…Inflamed tissues tend to increase the inflammatory mediators expression, which in turn may promote angiogenesis [25]. One of the major angiogenic activators is vascular endothelial growth factor (VEGF), which has been detected in vascular endothelial cells, inflammatory cells, junctional, sulcular and gingival epithelium during reparative processes [22,26]. Further factors of critical importance in the inflammation process are Ki-67 and nitric oxide synthases (NOS).…”

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical evaluation of the peri-implant soft tissues around machined and acid-etched titanium healing abutments: a prospective randomised study

et al. 2011

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A close spatial correlation has been described between the roughness of intraoral materials and the rate of bacterial colonisation. The aim of the present study in man was to conduct a comparative immunohistochemical evaluation of the inflammatory infiltrate, microvessel density, the nitric oxide synthases 1 and 3 and the vascular endothelial growth factor expression, the proliferative activity, and the B and T lymphocyte and histiocyte positivity in the peri-implant soft tissues around machined and acid-etched titanium healing caps. Ten patients participated in this study. The patients were enrolled consecutively. All patients received dental implants left to heal in a non-submerged mode. Healing caps were inserted in all implants. Half of the implants were supplied randomly with machined caps of titanium (control), while the other half were provided randomly with acid-etched titanium caps (test). After a 6-month healing period, a gingival biopsy was performed with a circular scalpel around the healing caps of both groups. The inflammatory infiltrate was mostly present in test specimens. Their extension was much larger than that of the control samples. A higher number of T and B lymphocytes were observed in test specimens. Higher values of microvessel density and a higher expression of vascular endothelial growth factor intensity were observed in the test samples. Furthermore, the Ki-67, NOS1 and NOS3 expression was significantly higher in the test specimens. All these results showed that the tissues around test healing caps underwent a higher rate of restorative processes, most probably correlated to the higher inflammation processes observed in these tissues.

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“…Its role in the development, progression, or healing of periodontal lesions has not been elucidated yet 17‐25 . In periodontal tissues, angiogenesis seems to be important both for the maintenance of tissue health and in chronic inflammatory periodontal diseases 17,19‐23 . Inflamed tissues seem to enhance the expression of inflammatory mediators, which in turn may promote angiogenesis 17 .…”

mentioning

confidence: 99%

Inflammatory Infiltrate, Microvessel Density, Nitric Oxide Synthase Expression, Vascular Endothelial Growth Factor Expression, and Proliferative Activity in Peri‐Implant Soft Tissues Around Titanium and Zirconium Oxide Healing Caps

Degidi

Artese²,

Perrotti

et al. 2006

Journal of Periodontology

245

169

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In our specimens, the inflammatory infiltrate was mostly present in the titanium specimens. Their extension was much larger than that of the zirconium oxide specimens. Higher values of MVD were observed in the titanium specimens (29.1 versus 15.8). In addition, a higher expression of VEGF intensity was observed in the peri-implant tissues of titanium healing caps, whereas predominantly lower expressions of VEGF intensity were noted around the zirconium oxide healing caps. The Ki-67 expression was higher in the titanium specimens. All these data revealed that the tissues around titanium healing caps underwent a higher rate of inflammation-associated processes, most probably correlated to the higher inflammation processes observed in these tissues. A higher intensity expression of NOS1 and NOS3 was recorded in the tissues around titanium, whereas, on the contrary, a lower intensity of expression was found in the tissues around zirconium oxide specimens. These latter data indicate that the higher expression of these two mediators could be correlated to the higher amount of bacteria present around the titanium samples.

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Vascular Endothelial Growth Factor and Transforming Growth Factor‐α and ‐β1 Are Released From Human Cultured Gingival Epithelial Sheets

Abstract: This study indicates that meaningful amounts of VEGF and TGF-alpha and -beta1 are released from HCGES, which suggests potential for promoting wound healing and tissue regeneration after grafting.

Cited by 21 publications

References 29 publications

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Histological and immunohistochemical evaluation of the peri-implant soft tissues around machined and acid-etched titanium healing abutments: a prospective randomised study

Inflammatory Infiltrate, Microvessel Density, Nitric Oxide Synthase Expression, Vascular Endothelial Growth Factor Expression, and Proliferative Activity in Peri‐Implant Soft Tissues Around Titanium and Zirconium Oxide Healing Caps

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