Variations in the fatty acid composition of lipid classes from lipoproteins in elderly women

Lecerf, Jean; Rossignol, Anne; Véricel, Evelyne; Thiès, Frank; Farnier, Michel; Lagarde, Michel

doi:10.1016/0021-9150(93)90133-f

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…These data are in agreement with two studies in hospitalised patients (Holman, 1979;Lecerf et al, 1993), although lower percentages of 20:4 n-6 were observed in PL from elderly hospitalised patients in another study (Asciutti-Moura, 1988). The data of our study suggest that in our cohort of elderly women living at home, the 20:4 n-6 dietary supply compensated both the lower 18:2 n-6 intake and possibly some weakness of the n-6 biosynthetic pathway.…”

Section: Discussionsupporting

confidence: 93%

“…As indicated above, lower percentages of 18:2 n-6 have been reported in elderly patients, but only in cohorts living in institutions or during hospitalisation (Holmann, 1979;Asciutti-Moura et al, 1988;Lecerf et al, 1993). The comparison of our population of elderly women living at home with data from the literature concerning institutionalised patients yielded interesting information.…”

Section: Discussionsupporting

confidence: 50%

“…60 years), linoleic acid was found to be signi®cantly lower in TG and PL than in the control group (Asciutti-Moura et al, 1988). More recently, a reduction in linoleic acid was also reported in almost all the plasma lipid fractions of VLDL, LDL and HDL, but in a very small group of hospitalised elderly women (79 ± 90 y) (Lecerf et al, 1993).…”

Section: Introductionmentioning

confidence: 90%

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Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected

Babin¹,

Abderrazik

Favier

et al. 1999

Eur J Clin Nutr

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Objective: To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect. Design and subjects: The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20 ± 48 y. Results: In elderly women, the n-6 series precursor, linoleic acid (18:2 n-6), was lower in TG and CE (P 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal fat intakes (P`0.0001), suggesting a lower dietary supply than in controls. Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P`0.0001). The ratios 20:4 n-6a20:3 n-6 and 22:6 n-3a20:5 n-3 were signi®cantly lower in PL from elderly women (P`0.005 and P`0.002, respectively), raising the question of the ef®ciency of the terminal steps of 20:4 n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis. Conclusion: The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected. Descriptors: non-institutionalised elderly women; polyunsaturated fatty acid; D5 desaturase; peroxisomal b oxidation; de®ciency; plasma lipid fractions; erythrocyte; capillary gas-chromatography

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 90%

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Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected

Babin¹,

Abderrazik

Favier

et al. 1999

Eur J Clin Nutr

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“…The different classes of complex lipids -triacylglycerols, cholesteryl esters and phospholipids -have different compositions of fatty acids. The fatty acid composition of these complex lipids in the different lipoproteins has been studied in detail in healthy subjects, and shown to be similar in VLDL, LDL and HDL (10)(11), thus confirming the rapid exchange of these lipids between these lipoproteins, mediated by the transfer proteins. In contrast, in animal species that lack cholesteryl ester transfer protein, such as the rat and the pig, the fatty acid profile of cholesteryl esters in the distinct lipoproteins is different (12)(13).…”

Section: ) Enzymesmentioning

confidence: 93%

Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases

Arranz

Lasunción²,

Perales³

et al. 1996

CCLM

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Summary: Liver damage and alterations in the exocrine function of the gland lead to a profound alteration of the plasma lipoprotein profile. To determine whether hepatic disease results in changes in the lipoprotein fatty acid composition, i. e. to determine whether liver function influences the homeostasis of complex lipids in plasma, we studied the fatty acid profile of lipids from VLDL, LDL and HDL, as well as from total plasma, in thirty-one patients of both sexes with hepatobiliary pathology (compensated liver cirrhosis, uncompensated liver cirrhosis, primary biliary cirrhosis, other intrahepatic cholestasis, and acute viral hepatitis). We also studied a group of healthy adults as controls. We present the lipoprotein profile and the fatty acid composition (myristic C14, palmitic C16, palmitoleic C16 : 1, stearic CIS, oleic CIS : 1, linoleic CIS : 2, eicosatrienoic C20 : 3co6 and arachidonic C20 : 4) of lipoprotein and total plasma triacylglycerols, cholesteryl esters and phospholipids. The main observation of this study is that, despite the profound changes in the lipoprotein profile and the lower abundance of polyunsaturated fatty acids in complex lipids, the composition of all triagylglycerols, cholesteryl esters and phospholipids is very similar for the corresponding lipoproteins of patients with hepatobiliary disease and of control subjects. This indicates that in the controls as in the studied patients, the exchange of lipids between plasmatic lipoproteins is very rapid and demonstrates the possible importance of the extrahepatic synthesis of cholesteryl ester transfer protein.

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“…Age-related changes in fatty acid profile have been described in postmeno pausal women: an increase in monounsaturated fatty acids (C l8:1 n-9 and C l6:1 n-9) and a decrease in linoleic acid (C l8:2 n-6) [17], However, the changes which may occur in plasma fatty acid profile of malnourished elderly and of elderly with coronary heart dis ease are poorly documented.…”

mentioning

confidence: 99%

Effects of Malnutrition and Atherosclerosis on the Fatty Acid Composition of Plasma Phospholipids in the Elderly

Bamberg

Pelletier²,

Blain³

et al. 1997

Ann Nutr Metab

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The fatty acid profiles of plasma phospholipids have been compared in 53 elderly subjects suffering from malnutrition (group U, 17 subjects) or from atherosclerosis (group A, 15 subjects). A control group was also included in the study (group C, 21 subjects). Main differences were observed in phosphatidylcholine (PC). In group U, the proportion of monounsaturated fatty acids increased in PC, which was reflected by an increase in unsaturated fatty acids without significant modification of essential fatty acids. In group A, no major modification has been observed statistically, although the proportion of saturated fatty acids tended to increase.

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Variations in the fatty acid composition of lipid classes from lipoproteins in elderly women

Cited by 11 publications

References 25 publications

Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected

Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected

Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases

Effects of Malnutrition and Atherosclerosis on the Fatty Acid Composition of Plasma Phospholipids in the Elderly

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