Effects of Malnutrition and Atherosclerosis on the Fatty Acid Composition of Plasma Phospholipids in the Elderly

Bamberg, T.; Pelletier, Xavier; Blain, Hubert; Jeandel, Claude; Debry, G

doi:10.1159/000177992

Cited by 2 publications

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“…The palmitic and palmitoleic acids were significantly high and low stearic was found in HBV-cirrhosis patients. Alvaro et al [ 43 ] found that an impaired FA elongation in cirrhosis may be due to augmented activity of Δ-9 desaturase and decreased the activity of elongase resulted in the decrease level of stearic acid and increased level of palmitoleic acid in cirrhosis patients [ 44 , 45 ]. The low level of linoleic acid increases the activity of Δ-9 desaturase [ 46 ], in addition, increased levels of palmitoleic and oleic acid with the FA status usually characterized by low linoleic acid [ 47 ] as observed in malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

et al. 2017

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BackgroundChronic HBV infection is a major cause of Cirrhosis and an important risk factor to develop hepatocellular carcinoma. The study is conducted to find out the changes in the lipid metabolism of HBV-cirrhosis patients.MethodsIn the present study, serum lipid profiles of patients with HBV-cirrhosis were assessed by utilizing micro-lab and gas chromatography, while risk factors for transmission of HBV-cirrhosis studied through the standard questionnaire.ResultsThe epidemiological and etiological risk factors strongly associated with HBV-cirrhosis patients compared to controls, included as family history, shave from the barber, blood transfusion (without proper screening), mutual sharing of household contents, positive surgery history, and dental treatment. The HBV-cirrhosis patients have significantly lower level (p < 0.001) of lipid profile including total cholesterol (96.65 mg/dl), TAG (82.85 mg/dl), VLDL-C (16.57 mg/dl), LDL-C (68.27 mg/dl), HDL-C (27 mg/dl) and total lipid (424.76 mg/dl) in comparison to controls, indicating hypolipidemia in patients. The MELD score indicated mild prognostic values of the hepatic function for the study group. The result of total fatty acid composition of HBV-cirrhotic patients with comparison of control subjects reveals that palmitic (24.54 g/100 g) and palmitoleic acid (4.65 g/100 g) were significantly (p < 0.05) higher whereas eicosatrienoic (0.09 g/100 g), arachidonic (3.57 g/100 g), linoleic (22.75 g/100 g) and α-linolenic acid (0.12 g/100 g) were significantly lower. Marker for stearoyl-CoA desaturase (SCD = ∆9-desaturase) activity i.e. palmitoleic: palmitic (0.2) and oleic: stearic acid (1.5) ratios, originated higher in HBV-cirrhotic patients, while PUFA: SFA (0.6) was lower in HBV-cirrhosis patients as compared with control subjects. The serum SFA and MUFA were increased while PUFA were reduced in both total and free form.ConclusionPresent study concluded that hypolipidemia observed in HBV-cirrhosis patients, MELD were found to be independent predictors of survival and alteration in fatty acid composition, possibly due to impairment in fatty acid metabolism by enzymatic elongation and desaturation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0437-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

et al. 2017

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“…(42,50) This process is even more exerted in the malnourished patients. Namely, low level of LA increased the activity of Δ-9 desaturase (51) increasing levels of palmitoleic and 18:1 n -9, with the FA status usually characterised by low LA n -6 (50,52) as observed in malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

Ristić‐Medić

Takić

Vučić

et al. 2013

J. Clin. Biochem. Nutr.

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The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p<0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p<0.001) and ratio of n-6/n-3 fatty acids was higher (p<0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic acid and long-chain PUFA were found in well-nourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation.

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Effects of Malnutrition and Atherosclerosis on the Fatty Acid Composition of Plasma Phospholipids in the Elderly

Cited by 2 publications

References 13 publications

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

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