Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases

Arranz, MC; Lasunción, Miguel A.; Perales, José C.; Herrera, Emílio; Lorenzo, Isabel; Cárcamo, Cristina; Concostrina, L; Villar, José R.; Gasalla, R

doi:10.1515/cclm.1996.34.9.701

Cited by 6 publications

(8 citation statements)

References 30 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, ARRANZ et al [28] found that when the FA profile changes, the CE fraction is more sensitive to that change than the PL fraction. Besides, analysis of the FA composition of triacylglycerols is valid only after a strict 12-h fast because of the rapid exchange of lipids between the intestinal and the circulatory systems.…”

Section: Discussionmentioning

confidence: 99%

Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis

Durieu¹,

Abbas‐Chorfa²,

Drai³

et al. 2007

European Respiratory Journal

View full text Add to dashboard Cite

The present authors investigated whether cystic fibrosis is linked to a defect in fatty acids and assessed the impact of the main patients' characteristics on the levels of several fatty acids, mostly during respiratory exacerbation and after antibiotic therapy.Fatty acid phospholipid and cholesteryl ester levels were measured in stable-state patients and controls. No differences were found concerning either the fractions of palmitic and oleic acids or the cholesteryl esters of a-linolenic and arachidonic acids. However, phospholipids of a-linolenic and arachidonic acids, as well as cholesteryl esters and phospholipids of stearic and linoleic acids, were lower in patients than in controls, but fractions of dihomo-c-linolenic, docosatetraenoic, docosapentaenoic, palmitoleic and eicosatrienoic acids were higher.Fatty acid levels, oxidative stress markers, nutrients, body mass index and forced expiratory volume in one second (FEV1) were measured in patients before and after antibiotic courses for bronchial exacerbation. After adjustments, palmitic, stearic, a-linolenic, linoleic, arachidonic, palmitoleic and oleic acids generally decreased during exacerbation but almost all increased after antibiotic courses. Nearly all fractions increased along with FEV1 and a positive relationship linked fatty acids to lipid hydroperoxides.There was no general drop in fatty acids. Patients' fatty acid profiles depended on the pulmonary function and the inflammation state.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis

Durieu¹,

Abbas‐Chorfa²,

Drai³

et al. 2007

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…Hepatic injury leads to changes in serum lipids, lipoprotein, cholesterol, triglycerides, and some related enzymatic activities (23). In addition, hepatic injury can be influenced by changes in polyunsaturated fatty acids (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Thioacetamide and Dexamethasone on Serum Lipids in Rats Fed on High-Fat Sunflower or Olive Oil Diets.

Esteban

et al. 1999

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryWe have previously reported that high-fat diets develop hepatic steatosis and, depending on the fat quality, affect serum lipid levels differently (J Nutr Sci Vitaminol, 1997, 43,155-160). The aim of this work is to study the influence of high-fat diets (14% sunflower or olive oils) on serum lipids in a model of hepatic acute damage induced by thioacet amide, and their influence when dexamethasone is administered before thioacetamide injection. Serum lipids and hepatic collagen have been evaluated using biochemical methods, and the steatotic process by histological staining. The results showed that hepatic steatosis and fibrosis are developed either by high-fat diets or thioacetamide injection. Pre treatment with dexamethasone did not decrease the hepatic collagen content. Thioacetamide injection alone or pretreatment with dexa methasone produced increases in serum tryglicerides (TG), total cholesterol (TC) and LDL-C in both high-fat diet groups, and a HDL-C increase in the olive-oil group, even though the atherogenic indices (HDL/TC and HDL/TG) were different depending on the enriched diet. The administration of high-fat diets to study the influence of the fat quality on health and disease should be interpreted carefully due to the ability of the diets themselves to cause hepatic damage.

show abstract

“…Being the smallest lipoproteins, HDL are secreted by the liver and intestine and transport cholesterol back to the liver 78 . Low HDL cholesterol levels are seen in human patients with liver diseases such as acute viral hepatitis and severe cholestasis 79 , as well as liver cirrhosis, and can arise from multiple causes 80 – 82 . Lower HDL cholesterol concentrations were also associated with decreased survival time in patients with liver cirrhosis and acute gastrointestinal bleeding 81 and also predicted the development of complications associated with liver cirrhosis 82 .…”

Section: Discussionmentioning

confidence: 99%

Metabolomic serum abnormalities in dogs with hepatopathies

Imbery

Dieterle

Ottka

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS, n = 24) or high serum liver enzyme activities (HLEA, n = 25) compared to control dogs (n = 64). A validated targeted proton nuclear magnetic resonance spectroscopy platform was used to assess 123 parameters. Principal component analysis of the serum metabolome demonstrated distinct clustering among individuals in each group, with the cluster of HLEA being broader compared to the other groups, presumably due to the wider spectrum of hepatic diseases represented in these samples. While younger and older adult control dogs had very similar metabolomic patterns and clusters, there were changes in many metabolites in the hepatopathy groups. Higher phenylalanine and tyrosine concentrations, lower branched-chained amino acids (BCAAs) concentrations, and altered fatty acid parameters were seen in cPSS dogs compared to controls. In contrast, dogs with HLEA had increased concentrations of BCAAs, phenylalanine, and various lipoproteins. Machine learning based solely on the metabolomics data showed excellent group classification, potentially identifying a novel tool to differentiate hepatopathies. The observed changes in metabolic parameters could provide invaluable insight into the pathophysiology, diagnosis, and prognosis of hepatopathies.

show abstract

Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases

Cited by 6 publications

References 30 publications

Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis

Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis

Effect of Thioacetamide and Dexamethasone on Serum Lipids in Rats Fed on High-Fat Sunflower or Olive Oil Diets.

Metabolomic serum abnormalities in dogs with hepatopathies

Contact Info

Product

Resources

About