Variations in association of Interleukin 6 -G174C single nucleotide polymorphism with type 2 diabetes mellitus—a review

Nadeem, Amina; Naveed, Abdul Khaliq; Hussain, Muhammad Ajaz; Aslam, Mohd; Siddiqui, Anwar Ali; Saeed, Sheikh A.

doi:10.1007/s13410-013-0147-x

Cited by 13 publications

(21 citation statements)

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“…SNP rs1800795 (-174G/C) of IL-6 gene in T2DM was first reported in 2003 showing that GG phenotype was a genetic determination of inflammation in the development of T2DM [18]. Significant sequence variation of IL-6 174G/C gene was widely distributed at varying frequencies in T2DM and healthy persons; this risk allele was also responsible for increased IL-6 serum level in genetically susceptible individuals [4]. However, the involvement of this SNP rs1800795 in diabetic complications in T2DM is unclear or controversial [5,19].…”

Section: Discussionmentioning

confidence: 99%

“…The single-nucleotide polymorphism (SNP) of IL-6 gene has attracted more and more attention recently. Significant sequence variation of IL-6 174G/C gene is widely distributed at varying serum IL-6 levels in genetically susceptible individuals [4]. G/C polymorphism at the position-174 in IL-6 promotor region (rs1800795) has been found to correlate with retinopathy, nephropathy [5], increased albumin-to-creatinine ratio as well as poor glycemic control and hyperlipidemia in Type 1 diabetes mellitus (T1DM) [6].…”

Section: Introductionmentioning

confidence: 99%

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The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

et al. 2020

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Objectives: To evaluate the effects of the single-nucleotide polymorphism (SNP) rs1800795 in interieukin-6 (IL-6) gene on diabetic microvascular complications of Type 2 diabetes mellitus (T2DM), using statistical meta-analysis. Methods: Literature pertaining to the relationship between the SNP rs1800795 and microvascular complications of T2DM including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and foot disease was retrieved from PubMed, Web of Science Knowledge and SinoMed databases. Original information was analyzed using Stata 12.0, including meta-analysis statistics, test for heterogeneity, evaluation of publication bias and sensitivity. Subgroup analysis was conducted to assess the effect of specific factors on the corresponding results. Results: In total, 14 eligible articles were obtained. The SNP rs1800795 in IL-6 gene is not correlated with risk of microvascular complications in T2DM. Among the original literature, a genetic model (OR = 1.071, 95% CI: 0.681–1.685, P=0.767), an allelic genetic model (OR = 1.010, 95% CI: 0.959–1.063, P=0.703), a heterozygote genetic model (OR = 1.107, 95% CI: 0.916–1.339, P=0.292), a dominant genetic model (OR = 1.108, 95% CI: 0.885–1.387, P=0.372), and a recessive genetic model (OR = 0.978, 95% CI: 0.646–1.478, P=0.917) were included respectively. In the subgroup analysis by types of diabetic microvascular complications, we found no correlation between the SNP rs1000795 polymorphism and complications of T2DM in either the homozygote genetic model or the allelic genetic model (P<0.05). Conclusion: Our results demonstrate that rs1800795 polymorphism in IL-6 gene is not correlated with the susceptibility of microvascular complications of T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

et al. 2020

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“…Single Nucleotida Pholimorphism (SNP)-G174C merupakan promotor gen pada IL-6 yang berasosiasi dengan T2DM, yang terkait juga dengan level dan resistensi insulin. IL-6 dapat menghambat auto-posporilasi reseptor insulin, menghambat transkripsi gen IRS, GLUT-4, dan PPAR-γ, serta mengaktifkan degradasi IRS-1 dan IRS-2 di dalam proteasom (Nadeem et al, 2013). Selain itu, saat terjadi inflamasi maka sel-sel akan menginduksi enzim siklooksigenase (COX-2) dan enzim tersebut akan beredar di daerah tempat terjadinya inflamasi (Persaud et al, 2004).…”

Section: Pendahuluan1unclassified

Pengaruh Intervensi Tahu Kedelai Hitam Kaya Serat Terhadap Glukosa Darah Dan Inflamasi Responden Diabetes Tipe 2

Putri

Zakaria

Prangdimurti

et al. 2016

jtip

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Type 2 diabetes mellitus (T2DM) subjects have a hyperglycemia condition. Hyperglycemia can cause oxidative stress that trigger glucose autooxidation and reactive oxygen species (ROS). ROS also triggers the inflammation and induces the cytokine signalling from cells and body tissues, such as interleukin and prostaglandin enzyme (COX-2 ABSTRAKPenderita diabetes melitus tipe 2 mengalami kondisi hiperglikemik. Hiperglikemik dapat menyebabkan stres oksidatif dan timbulnya reactive oxygen species (ROS). ROS dapat meningkatkan sekresi marker inflamasi seperti senyawa IL-6 dan enzim COX-2 oleh jaringan. Tujuan penelitian ini adalah untuk mengetahui pengaruh intervensi tahu kedelai hitam kaya serat (DFT) terhadap glukosa darah dan status inflamasi penderita diabetes melitus tipe 2. Responden dibagi menjadi 2 kelompok yaitu kelompok perlakuan (n=9) yang diintervensikan 80 g DFT selama 30 hari dan kelompok kontrol (n=9) yang tidak diberikan DFT. Glukosa darah puasa (GDP) dan parameter inflamasi (IL-6 dan enzim COX-2) dianalisis pada hari ke-0 dan hari ke-30. GDP dianalisis menggunakan glukometer, sedangkan nilai optical density IL-6 dan enzim COX-2 dianalisis dari plasma menggunakan metode ELISA. Hasil penelitian menunjukkan bahwa intervensi DFT mampu menurunkan nilai OD IL-6 (p=0,00) sebesar 22,82%, namun belum mampu menurunkan kadar GDP dan nilai OD enzim COX-2 (p=0,22 dan p=0,51) secara statistik. DFT berpotensi dalam menurunkan senyawa pro-inflamasi IL-6 responden diabetes melitus tipe 2.Kata kunci: diabetes melitus tipe 2, glukosa darah, inflamasi, tahu kedelai hitam PENDAHULUAN1Diabetes melitus termasuk salah satu penyakit tidak menular utama yang jumlah penderitanya terus meningkat terutama di 131 negara-negara berkembang seperti Indonesia. WHO (2014) mengemukakan bahwa pada tahun 2012 diabetes 131 melitus telah menyebabkan kematian 1,5 juta jiwa di dunia

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“…The IL-6 promoter -174G>C (rs1800795) polymorphism has been suggested to functionally affect IL6 promoter activity (Fishman et al, 1998). The rs1800795 G allele in homozygous (GG genotype) was associated with higher concentrations of IL-6 increasing the immune response (Larcombe et al, 2008;Nadeem et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Research Article Polymorphisms rs1800795 of interleukin-6 and rs2228145 of interleukin-6 receptor genes in Euro-Brazilians with adult-onset type 1 diabetes mellitus

Campos¹,

Graciolo²,

Sousa³

et al. 2019

Genet. Mol. Res.

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Type 1 Diabetes mellitus (T1D) is caused by the immune-mediated destruction of insulin-producing islet β cells, and its pathogenesis involves cytokines. Genetic background may influence cytokine signals, and polymorphisms may determine their impact on T1D autoimmunity. Several polymorphisms in and close to Interleukin-6 (IL-6) and Interleukin-6 Receptor (IL-6R) have been identified as associated with pathological processes. We investigated the IL-6 promoter-174G>C (rs1800795) and IL-6R Asp358Ala (rs2228145) polymorphisms in 141 Euro-Brazilian patients with adult-onset type 1 diabetes (diagnosis > 18 years old) and 150 healthy controls, matched by gender and age. Genotyping for both polymorphisms was performed by PCR-RFLP. PCR fragments for rs1800795 with Hsp92II and rs1800795 with HindIII were resolved by 15% polyacrylamide gel electrophoresis. The polymorphisms in both groups were in Hardy-Weinberg equilibrium. IL-6 rs1800795 was not different between healthy controls and T1D subjects, showing 27.3% (95% CI, 20-35%) and 30.1% (23-38%) for the C minor allele (-174C), respectively. For IL-6R rs2228145, the ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (3): gmr18260 L.P. Campos et al. 2 genotype (P = 0.046) and allele (P = 0.021) were different in the groups. The frequencies for rs2228145 C minor allele (358Ala) were 34.7% (27-43%) and 44.0% (36-51%) for controls and T1D subjects, respectively. In conclusion, IL-6 rs1800795 was not associated with adult-onset T1D; however, IL-6R rs2228145 was associated with T1D development in adulthood, and carriers of the minor C allele are at increased risk for adult-onset T1D (OR = 1.48; 95% CI = 1.06-2.07).

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Variations in association of Interleukin 6 -G174C single nucleotide polymorphism with type 2 diabetes mellitus—a review

Cited by 13 publications

References 37 publications

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus

Pengaruh Intervensi Tahu Kedelai Hitam Kaya Serat Terhadap Glukosa Darah Dan Inflamasi Responden Diabetes Tipe 2

Research Article Polymorphisms rs1800795 of interleukin-6 and rs2228145 of interleukin-6 receptor genes in Euro-Brazilians with adult-onset type 1 diabetes mellitus

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