Vaccination response following aerobic exercise: Can a brisk walk enhance antibody response to pneumococcal and influenza vaccinations?

Long, Joanna; Ring, Christopher; Drayson, Mark T.; Bosch, Jos A.; Campbell, John P.; Bhabra, Jagraj; Browne, D.; Dawson, Joel L.; Harding, Sarah; Lau, Jamie K.; Burns, Victoria E.

doi:10.1016/j.bbi.2012.02.004

Cited by 50 publications

(60 citation statements)

References 34 publications

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“…We previously demonstrated that long duration walking exercise did not significantly affect FLC levels [9]. The low intensity nature of the exercise task may not have elicited the pro-inflammatory effects typically seen in response to more intensive exercise modalities [16].…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum free light chain levels in healthy adults immediately after marathon running

Campbell

Eijsvogels

Wang

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Immunoglobulin κ and λ free light chains (FLC) are important serum biomarkers for diagnosing and monitoring plasma cell dyscrasias (via the κ:λ FLC ratio), and assessing immune competence and activation status (via ∑FLC). FLCs are produced, in excess of heavy chains, from healthy plasma cells during immunoglobulin production, but unlike intact immunoglobulins that are cleared by cellular catabolism over a number of weeks, FLC are rapidly cleared from the bloodstream by the renal glomerulus with a half-life of 3 (κ FLC)-6 (λ FLC) hours. Marathon running has been shown to acutely and transiently decrease renal function, however, the impact of prolonged aerobic exercise on FLC levels remains unknown. Methods: We measured serum FLC levels in 60 runners before, and immediately after, the 2010 Eindhoven Marathon. Results: A significant increase (p < 0.01) in κ FLC levels was observed after the marathon, and κ FLC correlated positively with serum creatinine levels. No changes were observed for λ FLC, and thus, there were subtle elevations

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Section: Discussionmentioning

confidence: 99%

Assessment of serum free light chain levels in healthy adults immediately after marathon running

Campbell

Eijsvogels

Wang

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Acute exercise may require a minimum threshold to exert such effects; a trial utilizing a brisk 45-minute walk resulted in no differences in subsequent antibody responses to influenza or pneumococcal pneumonia vaccines [95]. In addition, such benefits may not be observed in flu seasons in which robust responses are observed in the population in general, resulting in a ceiling effect [96].…”

Section: Interventions To Improve Antibody Responses To Vaccinationmentioning

confidence: 99%

Optimizing benefits of influenza virus vaccination during pregnancy: Potential behavioral risk factors and interventions

Christian

2014

Vaccine

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Pregnant women and infants are at high risk for complications, hospitalization, and death due to influenza. It is well-established that influenza vaccination during pregnancy reduces rates and severity of illness in women overall. Maternal vaccination also confers antibody protection to infants via both transplacental transfer and breast milk. However, as in the general population, a relatively high proportion of pregnant women and their infants do not achieve protective antibody levels against influenza virus following maternal vaccination. Behavioral factors, particularly maternal weight and stress exposure, may affect initial maternal antibody responses, maintenance of antibody levels over time (i.e., across pregnancy), as well as the efficiency of transplacental antibody transfer to the fetus. Conversely, behavioral interventions including acute exercise and stress reduction can enhance immune protection following vaccination. Such behavioral interventions are particularly appealing in pregnancy because they are safe and non-invasive. The identification of individual risk factors for poor responses to vaccines and the application of appropriate interventions represent important steps towards personalized health care.

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“…One study reported no difference in magnitude of enhancement when muscledamaging exercise of different intensities was used, 21 however, other studies have cited insufficient exercise intensity as an explanation for the lack of effect when a walking protocol was used. 24 Currently no study has compared different forms of exercise (such as aerobic vs. muscle damaging weights exercise), or duration of exercise. Measurements of aspects of the …”

Section: Disclosure Of Potential Conflicts Of Interestmentioning

confidence: 99%

Effects of exercise on vaccine-induced immune responses

Edwards

Booy

2013

Human Vaccines & Immunotherapeutics

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Vaccination response following aerobic exercise: Can a brisk walk enhance antibody response to pneumococcal and influenza vaccinations?

Cited by 50 publications

References 34 publications

Assessment of serum free light chain levels in healthy adults immediately after marathon running

Assessment of serum free light chain levels in healthy adults immediately after marathon running

Optimizing benefits of influenza virus vaccination during pregnancy: Potential behavioral risk factors and interventions

Effects of exercise on vaccine-induced immune responses

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