Assessment of serum free light chain levels in healthy adults immediately after marathon running

Campbell, John P.; Eijsvogels, Thijs M. H.; Wang, Yanyun; Hopman, Maria T. E.; Jacobs, Joannes F M

doi:10.1515/cclm-2015-0431

Cited by 6 publications

(5 citation statements)

References 19 publications

(32 reference statements)

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“…This might be due to the alteration of FLC λ is not consistent with FLC κ. Similar phenomenon was observed in healthy adults completed marathon running ( 46 ), which may induce acute and transient renal impairment ( 47 ). Further study is needed to explore why and how gut microbiome stimulate FLC λ.…”

Section: Discussionsupporting

confidence: 69%

Alteration of the Gut Microbiome in Chronic Kidney Disease Patients and Its Association With Serum Free Immunoglobulin Light Chains

Liu

Lin

et al. 2021

Front. Immunol.

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ObjectivesGut dysbiosis is associated with chronic kidney disease (CKD), and serum free immunoglobulin light chains (FLCs) are biomarkers for CKD. This study aims to assess the CKD gut microbiome and to determine its impact on serum FLC levels.MethodsTo control for confounders, 100 patients and sex- and age-matched healthy controls (HCs) were recruited. The gut microbiome was assessed by sequencing 16S rRNA gene V3-V4 hypervariable regions. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States was applied to infer functional metabolic pathways. When observing group differences in the microbiome and predicted metabolic pathways, demographic confounders were adjusted using binary logistic regression; when examining impacts of the gut microbiome and metabolic pathways on serum FLCs, factors influencing FLC levels were adjusted using multiple regression.ResultsPrincipal coordinate analysis revealed a significantly different bacterial community between the CKD and HC groups (P < 0.05). After adjusting for confounders, lower Chao 1, observed species and Shannon indices based on binary logistic regression predicted CKD prevalence. Actinobacteria, Alistipes, Bifidobacterium and Bifidobacterium longum enrichment, upregulation of metabolic pathways of bacterial toxin, chloroalkane and chloroalkene degradation, and Staphylococcus aureus infection also predicted CKD prevalence (P < 0.05). Furthermore, depletion of Actinobacteria and Bifidobacterium and reduced chloroalkane and chloroalkene degradation predicted high levels of FLC λ (P < 0.05).ConclusionsGut dysbiosis in CKD patients was confirmed by controlling for confounders in the present study. Additionally, the association between gut dysbiosis and FLC λ levels demonstrates the existence of crosstalk between the microbiome and immune response in CKD.

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Section: Discussionsupporting

confidence: 69%

Alteration of the Gut Microbiome in Chronic Kidney Disease Patients and Its Association With Serum Free Immunoglobulin Light Chains

Liu

Lin

et al. 2021

Front. Immunol.

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“…This study observed that daily life activities had an impact on increasing levels of immunoglobulins such as IgM. Studies have shown that exercise increases immunoglobulin, which may be due to exercise-induced immune activation or immunoglobulin redistribution ( Campbell et al, 2016 ). Similarly, this study shows that daily activities can induce immune activation by increasing IgM levels.…”

Section: Discussionmentioning

confidence: 84%

Effects of physical activity on clinical and inflammatory markers in diagnosing multiple myeloma patients

et al. 2023

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Multiple myeloma (MM) is the second most common hematological disorder. Although several drugs have been developed to treat MM, their efficacy is uncertain. In addition, how normal physical activities can decrease inflammatory responses and clinical biomarkers in MM patients needs to be better defined. Therefore, this study evaluated possible clinical and inflammatory markers to determine the early diagnosis of MM during physical activity. This study selected 30 MM patients with normal or no physical activity with ages of >50 years. This study did not require any specific exercise protocols other than noting patients’ daily life activities and considering them as physical activity for 17 days. Then, blood samples were collected to assess clinical and inflammatory markers. Regarding clinical markers, daily life activities in MM patients decreased their LDH, calcium, and β2-microglobulin levels significantly compared to other clinical biomarkers such as creatine and total protein. Further, this study observed no significant differences between daily life activities of MM patients and normal MM patients regarding levels of immunoglobulins except IgM. Furthermore, IL-6 level was significantly increased with the daily life activities of MM patients, suggesting the role of physical activities in increasing anti-inflammatory response along with altering the biochemical profiles including LDH, calcium and β2-microglobulin in MM patients.

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“…Although these high levels may be the result of the presence of another, non‐atopic disease, these subjects were apparently healthy and reported no medical conditions. Elevated serum Ig‐FLC levels have been shown in multiple myeloma [15 ], systemic lupus erythematosus [16 ], and rheumatoid arthritis patients [17 ], and were also reported shortly after marathon running [18 ].…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity

Thijs

Knipping

Bruijnzeel-Koomen

et al. 2016

Clin Transl Allergy

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BackgroundAlthough total IgE levels have been proposed as a biomarker for disease severity in atopic dermatitis (AD) and are increased in the majority of AD patients, they do not correlate with disease severity during short-term follow-up. During the synthesis of immunoglobulins, free light chains (Ig-FLCs) are produced in excess over heavy chains. In comparison with IgE molecules, Ig-FLCs have a very short serum half-life. Therefore, Ig-FLCs might be more suitable as a biomarker for disease severity during follow-up. Recent studies showed increased serum levels of kappa Ig-FLCs in infants with AD, correlating with disease severity. The aim of this study was to investigate serum kappa Ig-FLC levels in adults with AD, and their correlation to disease severity.MethodsSerum kappa If-FLC and total IgE levels were measured in 82 moderate to severe AD patients and 49 non-atopic controls. Blood was collected from patients before start of treatment with potent topical steroids (European classification: III–IV). 32 patients were treated during a clinical admission, and in this subpopulation a second blood sample was taken after 2 weeks of treatment. Clinical severity was determined by the Six Area Six Sign Atopic Dermatitis (SASSAD) severity score and a panel of serum biomarkers, including thymus and activation-regulated chemokine (TARC).ResultsSerum kappa Ig-FLCs levels in adult AD patients were not increased compared to non-atopic controls. Moreover, we observed no correlation between kappa Ig-FLC serum levels and disease severity determined by SASSAD and a panel of serum biomarkers, including TARC. Serum kappa Ig-FLC levels did also not decrease during treatment.ConclusionThere are no differences in serum kappa Ig-FLC levels between adult patients suffering from moderate to severe AD compared to non-atopic controls. Moreover, serum levels of kappa Ig-FLCs cannot be used as a biomarker for disease severity in adult AD.

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Assessment of serum free light chain levels in healthy adults immediately after marathon running

Cited by 6 publications

References 19 publications

Alteration of the Gut Microbiome in Chronic Kidney Disease Patients and Its Association With Serum Free Immunoglobulin Light Chains

Alteration of the Gut Microbiome in Chronic Kidney Disease Patients and Its Association With Serum Free Immunoglobulin Light Chains

Effects of physical activity on clinical and inflammatory markers in diagnosing multiple myeloma patients

Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity

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