Utilizing dextran to improve hemocompatibility of antimicrobial wound dressings with embedded quaternary ammonium salts

Gharibi, Reza; Kazemi, Shima; Yeganeh, Hamid; Tafakori, Vida

doi:10.1016/j.ijbiomac.2019.03.185

Cited by 57 publications

(50 citation statements)

References 47 publications

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“…Therefore, only the two membranes demonstrated two fingerprint peaks of the C–N deformation at 1564 and 1534 cm –1 , respectively, in the inset of Figure 3 with detailed plots from 1520 to 1580 cm –1 . 16−18…”

Section: Resultsmentioning

confidence: 99%

“…1 First, the polycations facilitate the adsorption of the bacteria onto the QAS antibacterial agent because of a higher positive charge density of the agent than that of the monomeric cations. 1,18 Second, the nonfixed small QAS molecules can raise health concerns. 1,19 Usually, the QAS molecule has a jointing group on the N + for binding the QAS molecule to the substrate.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effective Antibacterial Glass Fiber Membrane Prepared by Plasma-Enhanced Chemical Grafting

Guo¹,

Meng²,

Li³

et al. 2019

ACS Omega

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This paper reports a novel glass fiber membrane with an effective antibacterial performance by chemical grafting of quaternary ammonium salt (QAS) which is enhanced by a plasma bombardment technique. Plasma bombardment as a pretreatment of the membrane can increase the QAS anchored on the membrane from 0.8 to 1.3 wt %. The chemical grafting technique can increase the membrane zeta potential from negative values to positive values in aqueous solutions at various pHs. Furthermore, the plasma-enhanced chemical-grafting membrane has more positive zeta potentials (49.0 mV at pH = 7) than the chemical-grafting membrane without the plasma bombardment technique (38.9 mV at pH = 7). In the antibacterial performance evaluation, the Escherichia coli survival rate decreased from 127.0% of the pristine membrane to 4.1 and 11.3% of the plasma-enhanced chemical-grafting membrane and the chemical-grafting membrane, respectively. In addition, the plasma-enhanced chemical-grafting membrane shows durable antibacterial activity against E. coli with copious water rinsing as much as 3 L·cm–2.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effective Antibacterial Glass Fiber Membrane Prepared by Plasma-Enhanced Chemical Grafting

Guo¹,

Meng²,

Li³

et al. 2019

ACS Omega

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show abstract

“…The biodegradable, biocompatible, and drug‐free polymers have become popular for antibacterial wound dressing application that is a huge challenge for the health care products in the world 37,38 . Particularly, antibacterial polymers have played a key role in designing a functional wound dressing material 39 .…”

Section: Polymersmentioning

confidence: 99%

“… 46 Similarly, Inal and coworkers developed an antibacterial wound dressing composed by quaternary ammonium salt that is named poly([2‐(methacryloyloxy)ethyl] trimethylammonium chloride). They reported that the polymer exhibited very low cytotoxic effects and very good antibacterial efficacy aganist gram‐positive bacteria such as SA and Methicillin‐resistant Staphylococcus aureus (MRSA) and EC and gram‐negative bacteria such as Acinetobacter baumannii (AB) bacteria 37,47 …”

Section: Polymersmentioning

confidence: 99%

Advancements and future directions in the antibacterial wound dressings – A review

et al. 2020

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Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, a major obstacle to wound repair, cause an elevated inflammatory responses and result in ultimate outcome of incomplete and prolonged wound repair. To overcome these shortcomings, there is a growing requirement for antibacterial wound dressings. Dressings with antibacterial activities and multifunctional behaviors are highly anticipated to avoid the wound infection for successful healing. The aim of this review is not only to concentrate on the importance of antibacterial dressings for wound healing applications but also to discuss recent studies and some future perspectives about antibacterial wound dressings.

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“…Moreover, they should be semi-permeable for water and oxygen, should absorb wound exudate, and maintain moist environment at the wound site. Most important, they must prevent bacterial colonization [ 1 , 3 , 6 , 8 , 9 , 10 ]. Thus, advanced dressings are frequently improved with antimicrobial agents such as antibiotics [ 8 , 11 , 12 ], antiseptics [ 11 , 13 , 14 ], and metals [ 11 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

et al. 2020

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Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.

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Utilizing dextran to improve hemocompatibility of antimicrobial wound dressings with embedded quaternary ammonium salts

Cited by 57 publications

References 47 publications

Effective Antibacterial Glass Fiber Membrane Prepared by Plasma-Enhanced Chemical Grafting

Effective Antibacterial Glass Fiber Membrane Prepared by Plasma-Enhanced Chemical Grafting

Advancements and future directions in the antibacterial wound dressings – A review

Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

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