Utilization of Demineralized Bone Matrix to Restore Missing Buccal Bone During Single Implant Placement: Clinical Report

Bencharit, Sompop; Allen, Riley K.; Whitley, Daniel

doi:10.1563/aaid-joi-d-16-00054

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Over the last few decades, research has made it clear that implant materials should go beyond compatibility and actively promote bone formation. One approach has been to induce peri-implant bone formation through the use of osteoinductive agents such as demineralized bone matrix 5,6 and bone morphogenetic protein-2 (BMP2). 7,8 Alternative approaches have included the use of bone graft substitutes that are designed to be osteogenic through the use of a variety of factors, including platelet-rich plasma, [9][10][11] plateletderived growth factor, 12,13 and insulin-like growth factor-1, 14,15 as well as vasculogenic factors such as vascular endothelial growth factor (VEGF) 14,16 and fibroblast growth factor-2 (FGF2).…”

Section: Introductionmentioning

confidence: 99%

^{Roughness and Hydrophilicity as Osteogenic Biomimetic Surface Properties}

Boyan

Lotz

Schwartz

2017

Tissue Engineering Part A

133

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Successful dental and orthopedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics such as bone morphogenetic proteins. An understanding of the interaction between cells and the physical characteristics of their environments has led to development of bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and wettability of native bone have shown to provide cells in the osteoblast lineage with the structural cues to promote tissue regeneration and net new bone formation. Studies show that attachment, proliferation, differentiation, and local factor production are sensitive to these implant surface characteristics. This review focuses on how surface properties, including chemistry, topography, and hydrophilicity, modulate protein adsorption, cell behavior, biological reactions, and signaling pathways in peri-implant bone tissue, allowing the development of true biomimetics that promote osseointegration by providing an environment suitable for osteogenesis.

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