Retrospective analysis of porous tantalum trabecular metal–enhanced titanium dental implants

Edelmann, Alexander R.; Patel, D.J.; Allen, Riley K.; Gibson, Chad J.; Best, Al M.; Bencharit, Sompop

doi:10.1016/j.prosdent.2018.04.022

Cited by 32 publications

(19 citation statements)

References 14 publications

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“…An uncontrolled cross section study observed that Ta dental implants were clinically efficient under diverse clinical conditions [55]. Further clinical research confirmed that Ta implants exhibited less peri-implant bone loss than Ti specimens [56]. Taken altogether, our results give an overview of the healing process of proliferation-differentiation-mineralization around titanium and porous tantalum implants.…”

Section: Discussionsupporting

confidence: 51%

Porous Tantalum vs. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation

Piglionico

Bousquet

Fatima

et al. 2020

JCM

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Titanium dental implants are used routinely, with surgical procedure, to replace missing teeth. Even though they lead to satisfactory results, novel developments with implant materials can still improve implant treatment outcomes. The aim of this study was to investigate the efficiency of porous tantalum (Ta) dental implants for osseointegration, in comparison to classical titanium (Ti). Mesenchymal stem cells from the dental pulp (DPSC) were incubated on Ta, smooth titanium (STi), and rough titanium (RTi) to assess their adhesion, proliferation, osteodifferentiation, and mineralized matrix production. Cell proliferation was measured at 4 h, 24 h, 48 h with MTT test. Early osteogenic differentiation was followed after 4, 8, 12 days by alkaline phosphatase (ALP) quantification. Cells organization and matrix microstructure were studied with scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Collagen production and matrix mineralization were evaluated by immunostaining and histological staining. MTT test showed significantly higher proliferation of DPSC on Ta at 24 h and 48 h. However, APL quantification after 8 and 12 days was significantly lower for Ta, revealing a delayed differentiation, where cells were proliferating the more. After 3 weeks, collagen immunostaining showed an efficient production of collagen on all samples. However, Red Alizarin staining clearly revealed a higher calcification on Ta. The overall results tend to demonstrate that DPSC differentiation is delayed on Ta surface, due to a longer proliferation period until cells cover the 3D porous Ta structure. However, after 3 weeks, a more abundant mineralized matrix is produced on and inside Ta implants. Cell populations on porous Ta proliferate greater and faster, leading to the production of more calcium phosphate deposits than cells on roughened and smooth titanium surfaces, revealing a potential enhanced capacity for osseointegration.

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Section: Discussionsupporting

confidence: 51%

Porous Tantalum vs. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation

Piglionico

Bousquet

Fatima

et al. 2020

JCM

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“…This special geometric structure and strength are of great significance to the biological properties of implanted materials. PTTM has long been used in orthopedics to promote neovascularization, wound healing and osteogenesis, and in recent years, it has been incorporated into Ti alloy dental implants [97][98][99]. In vivo experiments, studies have shown that the bone growth, the amount of new mineralized bone and the rate of new bone formation of Ta trabecular dental implant (TM) is better than that of Ti dental implant (TSV), and TM dental implant has considerable implant stability and bone-implant contact [100,101].…”

Section: Porous Tantalum Trabecular Metalmentioning

confidence: 99%

“…In vivo experiments, studies have shown that the bone growth, the amount of new mineralized bone and the rate of new bone formation of Ta trabecular dental implant (TM) is better than that of Ti dental implant (TSV), and TM dental implant has considerable implant stability and bone-implant contact [100,101]. At present, many studies have incorporated TM into Ti alloy dental implants to improve osseointegration, and the results show that there is less bone loss around TM implants than the Ti group [99]. Macheras et al analyzed the survival rate of the porous Ta acetabular component in primary total hip arthroplasty (THA) and followed up for an average of 18 years.…”

Section: Porous Tantalum Trabecular Metalmentioning

confidence: 99%

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Li¹,

Yao²,

Zhang³

et al. 2020

SN Appl. Sci.

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Repair, reconstruction, and replacement of congenital malformations, either in case of exogenous or iatrogenic tissue and organ defects, requires utilization of a large number of personalized biomaterials. In recent decades, the improvement of people's quality of life and the prolongation of life expectancy have promoted the development of medical and material science. In addition to the traditionally used stainless steel, other materials such as cobalt-chromium alloy, pure titanium, titanium alloy, and the newly alloy materials continue to emerge, such as tantalum-based alloy materials which have been used in clinic, especially the application of porous tantalum trabecular metal in orthopedics. This paper which has provided good preliminary works for the development of tantalum biomaterials with more advantages in the future such as tantalum dental implants summarizes in detail the progress of tantalum materials in physicochemical properties and biocompatibility in recent years. From the comparison of surface passivation films of different metals in different environments, the electrochemical corrosion behavior of tantalum, the release of different metal ions and the damage to cells, it is concluded that tantalum has excellent corrosion resistance. Besides, the excellent biocompatibility of tantalum metals concluded by cytology, molecular biology, protein adsorption experiment, and hematology experiment, as well as regular follow-up observation of patients with porous tantalum trabecular metal in clinic. The excellent corrosion resistance and biocompatibility of the tantalum metal have a very wide prospect in clinical application.

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“…The immediate loading tests of porous Ta enhanced implants demonstrated significantly less marginal bone loss than that of threaded implants (0.43±0.41 mm Vs 0.98±0.67 mm) after 1-year of functional loading [171]. This result was then further corroborated in a retrospective study in which an average of 0.28 mm bone gain could be found in porous Ta enhanced group, but the Ti group showed an average of 0.2 mm marginal bone loss after 1-year of implant loading [172].…”

Section: Dental Implantsmentioning

confidence: 61%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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Retrospective analysis of porous tantalum trabecular metal–enhanced titanium dental implants

Cited by 32 publications

References 14 publications

Porous Tantalum vs. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation

Porous Tantalum vs. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

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