Use of antibacterial agents in an intensive care unit in a hospital in Brazil

Santos, Edilson Floriano dos; Lauria-Pires, Liana; Pereira, Mercedes; Silva, A.E.; Rodrigues, Isabela Pereira; Maia, MO

doi:10.1590/s1413-86702007000300011

Cited by 14 publications

(12 citation statements)

References 16 publications

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“…Santosh EF et al, reported that DDD/100 bed days ampicillin+sulbactam was 41.74. 17 Wiliams et al, reported that DDD/100 bed days of amikacin and metronidazole were 8.15 and 14.65 respectively which was higher compared to our study. 5 Due to amoxicillinclavulanate as broad spectrum anti-microbial, amikacin effective against abdominal enterobacteria and metronidazole effective against anaerobe they were prescribed significantly in surgical and neurosurgical ICU to prevent post operative infections.…”

Section: Analysis Of Ddd Of Antimicrobials Groupcontrasting

confidence: 76%

“…DDD/100 bed days of vancomycin was higher in surgical ICU (0.48) while study carried out at Brazil reported that DDD/100 bed days of vancomycin was 13.13 which was higher compared to our study. 17 Vancomycin was prescribed against methicillin resistant Staphylococcus aureus which was observed in more in surgical ICU. DDD/100 bed days of linezolid was one (1) in neurosurgical ICU.…”

Section: Analysis Of Ddd Of Antimicrobials Groupmentioning

confidence: 99%

See 1 more Smart Citation

A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India

Shelat¹,

Gandhi²,

Patel³

2015

JYP

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Objective: The goal of study is to identify drug and antimicrobial utilization in ICUs by using daily defined dose. Material and Methods: Study was conducted at tertiary care teaching hospital. 100 patients in each medical, surgical and neurosurgical ICU were included. The data were recorded in preformed Case Record Form (CRF). Drugs were classified using the anatomical therapeutic chemical (ATC) classification system and drug utilization was measured as Daily Defined Dose (DDD)/100 bed days. Data were analyzed by Z and x 2 test. Results: DDD/100 bed days of inotropes was 51.44 in medical ICU which was significantly (p<0.05) higher compared to surgical and neurosurgical ICU while DDD/100 bed days of gastrointestinal drugs was 44.52, 38.57 and analgesics was 34.5, 34.41 in surgical and neurosurgical ICU respectively which was significantly (p<0.05) higher as compared to medical ICU. More than two antimicrobials were prescribed in above 70% patients in all ICU. DDD/100 bed days of cephalosporin was 20.76 in medical ICU which was significantly(p<0.05) higher compared to surgical and neurosurgical ICU. DDD/100 bed days of aminoglycosides was 16.01, 17.65 and nitroimidazole was 10.3, 8.4 in surgical and neurosurgical ICU respectively which was significantly (p<0.05) higher compared to medical ICU. Among restricted antimicrobials according to antimicrobial policy of hospital. DDD/100 bed days of piperacillin+tazobactam and cefoperazone+sulbactam were significantly (p<0.05) higher in medical ICU. Levoflxoacin and vancomycin were highly sensitive antimicrobials followed by beta lactam antimicrobials with beta lactamase inhibitors in all ICUs. Conclusion: Polypharmacy was observed in ICU and antimicrobials widely prescribed in ICUs. Sensitivity of beta lactam along with beta lacatamase inhibitors was high.

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Section: Analysis Of Ddd Of Antimicrobials Groupcontrasting

confidence: 76%

Section: Analysis Of Ddd Of Antimicrobials Groupmentioning

confidence: 99%

A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India

Shelat¹,

Gandhi²,

Patel³

2015

JYP

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“…Entre las limitaciones del estudio se puede señalar que no refleja el uso de estos medicamentos en combinaciones o esquemas terapéuticos. Tampoco evalúa la calidad de la prescripción, el cumplimiento de las Guías Clínicas o se lo asocia indicadores de infecciones intrahospitalarias 10,26 . A diferencia de otros estudios 6,27 este trabajo no evalúa los costos del uso de antimicrobianos.…”

Section: Discussionunclassified

Consumo de antimicrobianos en la Unidad de Terapia Intensiva del Hospital Dr. Guillermo Rawson-San Juan, Argentina

Vega

Fontana

Iturrieta

et al. 2015

Rev. chil. infectol.

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“…Cinq études monocentriques, non randomisées, de type « avant-après » se sont intéressées à la question. Elles ont évalué la consommation d'antibiotiques [228,[259][260][261], l'adéquation des antibiotiques prescrits comparativement aux recommandations [260], l'évolution des coûts d'antibiotiques [228,259,261] et pour certaines la mortalité [228,260]. Hors réanimation, il existe des études suggérant aussi l'intérêt de l'avis d'une équipe d'infectiologie [262,263].…”

Section: Concernant La Procalcitonine (Pct)unclassified

Stratégies de réduction de l’utilisation des antibiotiques à visée curative en réanimation (adulte et pédiatrique)

Bretonnière

2015

Anesthésie & Réanimation

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Use of antibacterial agents in an intensive care unit in a hospital in Brazil

Cited by 14 publications

References 16 publications

A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India

A Study of Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU)s at Tertiary Care Teaching Hospital, India

Consumo de antimicrobianos en la Unidad de Terapia Intensiva del Hospital Dr. Guillermo Rawson-San Juan, Argentina

Stratégies de réduction de l’utilisation des antibiotiques à visée curative en réanimation (adulte et pédiatrique)

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