The opinions of Argentinian pharmacists from different places and professional practice settings were obtained. In all work settings, "lack of time" is the main barrier to overcome for implementing pharmaceutical care.
Pharmacovigilance is responsible for monitoring the safety of medicines in normal clinical use and during clinical trials. Legal requirements for pharmacovigilance in some Latin American countries (Argentina, Brazil, Chile, Paraguay and Uruguay) were reviewed. Disparities in the legal framework among the countries are observed being those for marketing authorization holders one of the most evident. The active rol of the universities and drug information centers for/of pharmacovilance seems to be a positive common point. Legal requirements regarding pharmacovigilance of biosimilar medicines, is still a point to be developed.
<p>Los principales usos aprobados de suspensiones de IgG intravenosa (IgGiv) son agamaglobulinemias, trombocitopenias inmunes, artritis reumatoidea, síndrome de Guillán-Barré, miastenia gravis, esclerosis múltiple. Se propone IgGiv como inmunomoduladora en fallas reproductivas ya que se utiliza para evaluar tasas de recién nacidos en mujeres con fallas reiteradas en implantación (FRI) y abortos recurrentes (AbR). Sin embargo, esta indicación no se especifica en el prospecto (“uso <em>off-label</em>”).</p><p>Entre 2010 y 2015 se realizó anamnesis e historia clínica reproductiva completa a 2333 parejas evaluando varios factores. De 447 embarazos, 143 pacientes recibieron tratamiento con IgGiv UNC. 79 consultaron por AbR (55%) y 64 por FRI (45%). El diagnóstico de tiroiditis de Hashimoto fue positivo en 91 pacientes (64%). En 3 pacientes (2%) se observaron reacciones adversas. Los recién nacidos vivos fueron 83, tasa de éxito 58%. Esta alta tasa y la ausencia de reacciones adversas son evidencias de efectividad y seguridad de IgGiv.</p>
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