2023
DOI: 10.3390/pathogens12020297
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Unusual Observations in Leishmaniasis—An Overview

Abstract: Leishmaniasis significantly affects the population of the tropics and subtropics. Clinical features and infective species of Leishmania are the primary factors driving the direction of diagnosis. The rise in incidences of atypical presentations present a challenge in patient treatment. Knowledge of unusual/rare presentations can aid in having a broader perspective for including the different aspects during the examination and thus avoid misdiagnosis. A comprehensive literature survey was performed to present t… Show more

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Cited by 13 publications
(9 citation statements)
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References 205 publications
(233 reference statements)
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“…Nucleic acid sequence-based amplification (NASBA), using RNA polymerase to produce RNA and reverse transcriptase, provides superior sensitivity but does not allow the differentiation of Leishmania species. The methods of PCR-RFLP (restriction fragment length polymorphism) and AFLP (amplified fragment length polymorphism) are distinguished by the digestion of amplified DNA with restriction endonucleases and the analysis of the generated fragments, providing increased sensitivity, in particular for samples with low parasite load, and allowing the precise genomic analysis of different Leishmania spp., including the distinction between closely related strains [ 44 ].…”
Section: Resultsmentioning
confidence: 99%
“…Nucleic acid sequence-based amplification (NASBA), using RNA polymerase to produce RNA and reverse transcriptase, provides superior sensitivity but does not allow the differentiation of Leishmania species. The methods of PCR-RFLP (restriction fragment length polymorphism) and AFLP (amplified fragment length polymorphism) are distinguished by the digestion of amplified DNA with restriction endonucleases and the analysis of the generated fragments, providing increased sensitivity, in particular for samples with low parasite load, and allowing the precise genomic analysis of different Leishmania spp., including the distinction between closely related strains [ 44 ].…”
Section: Resultsmentioning
confidence: 99%
“…VL presents as a zoonosis in Brazil, affecting humans and dogs and less frequently other animals, caused by Leishmania infantum 2 . Transmission occurs mostly from the bite of infected female sandflies, which acquire promastigotes at the time of a blood meal in reservoir animals.…”
Section: Introductionmentioning
confidence: 99%
“…Current treatment of leishmaniasis, a complex of vector-borne diseases caused by parasitic protists of the genus Leishmania , remains a challenge [ 1 , 2 , 3 ]. The lack of a vaccine makes chemotherapy the only way to manage the infection when the first symptoms appear.…”
Section: Introductionmentioning
confidence: 99%