Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines
Estela Melcón-Fernandez,
Endika Martín-Encinas,
Francisco Palacios
et al.
Abstract:In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages include cost, the need to maintain a cold chain, the route of administration, the associated adverse effects and the generation of resistance. In this work we have evaluated the antileishmanial effect of 1,5- and 1,8-substituted fused naphthyridines through in vitro and ex vivo assays, using gene… Show more
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