Unusual malignant transformation of juvenile recurrent respiratory papillomatosis

Sidhu, Tejbir S.; Sharma, Anupam; Sharma, Nitasha; Sen, A. K.; Das, B. C.

doi:10.1016/j.otohns.2005.03.047

Cited by 6 publications

(6 citation statements)

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“…High-risk human papillomaviruses (HR-HPVs) are carcinogenic viruses which are primarily associated with cervical cancer but are also linked with other anogenital cancers and cancers of other organ sites [5] such as oral cavity [6-8], esophagus [9-11], nasopharyngeal and laryngeal carcinoma [5,12-15] and possibly in retinoblastoma [16-18]. In India, HPV is found to be present in 100% of cervical cancer specimens and prevalence of high risk HPV type 16 is exceptionally high (~90%) in them [19].…”

Section: Introductionmentioning

confidence: 99%

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

et al. 2011

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BackgroundTwo clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present in many other carcinomas in extra-genital organ sites. Presence of HPV has been reported in breast carcinoma which is the second most common cancer in India and is showing a fast rising trend in urban population. The two early genes E6 and E7 of HPV type 16 have been shown to immortalize breast epithelial cells in vitro, but the role of HPV infection in breast carcinogenesis is highly controversial. Present study has therefore been undertaken to analyze the prevalence of HPV infection in both breast cancer tissues and blood samples from a large number of Indian women with breast cancer from different geographic regions.MethodsThe presence of all mucosal HPVs and the most common high-risk HPV types 16 and 18 DNA was detected by two different PCR methods - (i) conventional PCR assays using consensus primers (MY09/11, or GP5+/GP6+) or HPV16 E6/E7 primers and (ii) highly sensitive Real-Time PCR. A total of 228 biopsies and corresponding 142 blood samples collected prospectively from 252 patients from four different regions of India with significant socio-cultural, ethnic and demographic variations were tested.ResultsAll biopsies and blood samples of breast cancer patients tested by PCR methods did not show positivity for HPV DNA sequences in conventional PCRs either by MY09/11 or by GP5+/GP6+/HPV16 E6/E7 primers. Further testing of these samples by real time PCR also failed to detect HPV DNA sequences.ConclusionsLack of detection of HPV DNA either in the tumor or in the blood DNA of breast cancer patients by both conventional and real time PCR does not support a role of genital HPV in the pathogenesis of breast cancer in Indian women.

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Section: Introductionmentioning

confidence: 99%

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

et al. 2011

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“…Although RRLP is histologically a benign proliferation of stratified squamous epithelium and is usually limited to the larynx its spread to the tracheobronchial tree occurs in 2% to 29% of cases and pulmonary parenchyma in less than 1% to 7% [1]. Adult onset RRLP is usually associated with solitary lesions which do not spread as readily as juvenile forms and recurrence is low after removal [1,3]. In the present case, we report on tracheobronchopulmonary spread of RRLP in a 39-year-old female patient without any evidence of associated HPV infection.…”

Section: Resultsmentioning

confidence: 99%

“…The etiology of the disease is the human papilloma virus (HPV) [3]. The most common types of the virus that have been identified are HPV types 6 and 11 [4].…”

Section: Discusionmentioning

confidence: 99%

“…RRLP is known to undergo malignant transformation. Spontaneous malignant degeneration in nonirradiated RLP has been reported in both the laryngotracheal and bronchioalveolar areas, the reported incidence being 2% to 3% and occurs within 10 years of diagnosis [3,7]. It is thought to be associated with extrinsic factors such as smoking and radiation therapy.…”

Section: Discusionmentioning

confidence: 99%

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Pulmonary Manifestations of Juvenile Laryngotracheal Papillomatosis: Case Report and Literature Review

Škarda¹,

Tichà²,

Tich³

et al. 2009

TOPATJ

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Abstract:In the present report, we report on a rare case of tracheobronchopulmonary spread of childhood recurrent laryngeal papillomatosis without ana association to prior HPV infection, in a 39-year-old female patient.Recurrent laryngeal papillomatosis (RRLP) is a rare benign disease seen in children and a fewcases are reported in adults. Although RRLP is histologically a benign proliferation of stratified squamous epithelium and is usually limited to the larynx its spread to the tracheobronchial tree occurs in 2% to 29% of cases and to the pulmonary parenchyma in less than 7% of cases. CASE REPORTA woman 39 years of age with bilateral focal lesions of the lung. Wedge excision of the lesion in the right lung filled with a purulent secretion. Macroscopic AppearanceThe lung tissue, 42x30x20 mm in size had multiple yellowish and graysh lesions of varying size from 2-15 mm with purulent content in the center of the largest lesion. HISTOLOGICAL FINDINGSA-E: In all tisuue sections, the findings were identical, as follows: in lung parenchyma several cavitated lesions lined with sheet-like solid masses of squamous proliferations or flat squamous epithelium could be observed. Similar free epithelial sheets could also be seen in the alveolár spaces without any relationship to the above-mentioned cysts. The epithelium showed dyskeratotic changes with evidence of clear maturation without mitoses or dysplastic changes. The given lesion had oval margins without evidence of invasive growth. Keratin and focal spumoid macrophages could be detected in the alveolar spaces and in the lumen of the lesion (Figs. 1, 2). Due to the peculiarity of the histological picture and vague information from the clinician, we searched the patient database and found that the patient had recurrent laryngeal papillomatosis.The above histological picture is compatible with pulmonary manifestation of juvenile laryngeotracheal papillomatosis or pulmonary parenchymal papillomatosis.*Address correspondence to this author at the Department of Pathology and Laboratory of Molecular Pathology, Medical Faculty, Palacky University, Olomouc, Czech Republic; E-mail: jojos@email.cz § Both authors contributed equally to the study. Fig. (1). In lung parenchyma several cavitated lesions lined with sheet-like solid masses of squamous proliferations or flat squamous epithelium could be observed. Similar free epithelial sheets could also be seen in the alveolar spaces without any relationship to the above-mentioned cysts. Fig. (2). The epithelium showed dyskeratotic changes with evidence of clear maturation without mitoses or dysplastic changes. The given lesion had oval margins without evidence of invasive growth. Keratin and focal spumoid macrophages could be detected in the alveolar spaces and in the lumen of the lesion 100x HE.

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“…There exist two distinct types of RRP: adult-onset RRP and juvenile-onset RRP. Adult-onset RRP does not usually involve the lower airways, and its occurrence rate is quite low [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Recurrent respiratory papillomatosis with lung involvement

Molodtsova

Ryabova

Dvorakovskaya

et al. 2018

Respiratory Medicine Case Reports

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Unusual malignant transformation of juvenile recurrent respiratory papillomatosis

Cited by 6 publications

References 6 publications

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

Pulmonary Manifestations of Juvenile Laryngotracheal Papillomatosis: Case Report and Literature Review

Recurrent respiratory papillomatosis with lung involvement

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