Recurrent respiratory papillomatosis with lung involvement

Molodtsova, V P; Ryabova, M.A.; Dvorakovskaya, Ivetta; Vasilyeva, M A; Akopov, Andrey

doi:10.1016/j.rmcr.2018.10.019

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…Although the most common sites of this benign tumor have been proposed to be the soft palate, lip and gingiva (1,11), the tongue was suggested to be the most common site (8,10). However, squamous cell papilloma has also been documented to occur in the trachea, nasal cavity, sinuses, external auditory canal, esophagus and throat (12)(13)(14). The majority of cases are characterized by the absence of a clear unified set of symptoms, with clinical manifestations typically arising from secondary symptoms caused by physical obstruction.…”

Section: Discussionmentioning

confidence: 99%

Squamous papilloma involving the mandible: A case report and descriptive literature review

Zheng,

Liu,

Cao

et al. 2024

Exp Ther Med

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Squamous papilloma is a benign neoplasm that originates from the stratified squamous epithelium of the mucous membrane. Its principal etiological factor is human papillomavirus infection, with a predilection for manifesting within the oral cavity. Squamous papilloma predominantly affects regions on the palate, cheeks, lips and tongue. However, to the best of our knowledge, the occurrence of squamous papilloma within the confines of the mandible remains unreported hitherto. The present report documents a case of squamous papilloma involving the mandible who was managed at the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) in January 2023. The patient underwent a series of recurrent jaw inflammations, manifesting with malignant imaging characteristics. Subsequent pathological analysis confirmed a diagnosis of papilloma in the jaw. The present report highlights the pivotal role of prolonged inflammation in the genesis of jaw squamous papilloma, prompting avenues for further investigation, including the potential of inflammation to induce aberrant cell growth, mediate cell interactions, orchestrate cytokine actions and influence stress mediators. In addition, the current study posits a plausible connection between persistent inflammation, compromised epithelial integrity and an increased likelihood of head and neck papilloma, particularly concerning human papillomavirus infection. This article delineates the clinical attributes of the uncommon manifestations of jaw papilloma and delves into the associated mechanisms, thereby contributing to an enhanced comprehension of jaw disorders. This comprehensive insight equips clinicians with a heightened knowledge base for more precise diagnosis and treatment of analogous cases.

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Section: Discussionmentioning

confidence: 99%

Squamous papilloma involving the mandible: A case report and descriptive literature review

Zheng,

Liu,

Cao

et al. 2024

Exp Ther Med

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“…La PRR, conocida como una neoplasia benigna de la laringe, es causada por el virus del VPH (7,(12)(13)(14)(15) . La frecuencia de PRR es más del doble en la población juvenil comparado con los adultos (5) ; además la edad temprana es el factor más importante de gravedad de la enfermedad (16) .…”

Section: Discussionunclassified

Papilomatosis laríngea recurrente con compromiso pulmonar: reporte de caso

Saavedra

Chiara-Chilet

Maquera-Afaray

et al. 2023

Rev Peru Med Exp Salud Publica

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La papilomatosis respiratoria recurrente es una enfermedad neoplásica causada por el virus del papilomahumano y caracterizada por el crecimiento de lesiones proliferativas exofíticas que afectan la mucosa de las vías respiratorias. En su epidemiología se presenta una distribución bimodal, con una forma juvenil en menores de 20 años, más agresiva, con múltiples lesiones apilomatosas y alta frecuencia de recurrencia, en comparación con la forma adulta. El compromiso pulmonar es poco frecuente y su manejo es un desafío. Se presenta el caso de un varón de 13 años con antecedente de papilomatosis laríngea desde los dos años. El paciente mostró dificultad respiratoria y múltiples nódulos estenosantes en laringe y tráquea, y varios quistes pulmonares visualizados en la tomografía de tórax. Se le realizó exéresis de las lesionespapilomatosas y traqueostomía. Recibió dosis única de bevacizumab 400 mg intravenoso y terapias respiratoriascon evolución favorable, sin recurrencias en el seguimiento.

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“…RRP is a rare disorder and involvement of the lungs is very rare [1][2][3]7]. Although the disease is benign, it can lead to severe morbidity and mortality due to airway obstruction and malignant transformation to carcinoma in the affected organs [1][2][3]5].…”

Section: Discussionmentioning

confidence: 99%

“…Recurrent Respiratory Papillomatosis (RRP) is a rare disease characterized by recurrent growth of papillomas primarily in the larynx and occasionally in other parts of the aerodigestive tract [1,2]. Although RRP is a benign disease, malignant transformation to squamous cell carcinoma has been described [2][3][4][5]. RRP is caused by Human Papilloma Virus (HPV) subtypes 6 or 11, of which subtype 11 more often leads to severe affection of the larynx, trachea and bronchi and malignant transformation [2,3].…”

Section: Introductionmentioning

confidence: 99%

Recurrent respiratory papillomatosis with lower airway involvement in a young woman

Mamaeva

Mehlum

Davidsen

2020

European Clinical Respiratory Journal

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Radiological presentation of bronchiectasis should prompt the respiratory physician to investigate various differential diagnosis leading to this condition. This case report describes a young nonsmoking woman with HPV11 induced laryngeal Recurrent Respiratory Papillomatosis (RRP) since early childhood, who developed progressive exertional dyspnea. A thorough diagnostic process revealed HPV11 infection in the lung parenchyma consistent with RRP in the lower airways, an HPV infection that was most likely obtained from the patient´s mother during vaginal birth.This case report illustrates that also respiratory physicians should keep RRP in mind in persons with the radiological presentation of bronchiectasis previously diagnosed RRP in the upper airways.

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Recurrent respiratory papillomatosis with lung involvement

Cited by 7 publications

References 13 publications

Squamous papilloma involving the mandible: A case report and descriptive literature review

Squamous papilloma involving the mandible: A case report and descriptive literature review

Papilomatosis laríngea recurrente con compromiso pulmonar: reporte de caso

Recurrent respiratory papillomatosis with lower airway involvement in a young woman

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