Untersuchungen �ber den enzymatischen Alkoholabbau beim Menschen unter besonderer Ber�cksichtigung des Intermedi�rstoffwechsels

Stuhlfauth, K; Englhardt-Golkel, A; Schaffry, J

doi:10.1007/bf01473101

Cited by 14 publications

(3 citation statements)

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“…Furthermore the acetaldehyde formed from ethanol could compete with glyceraldehyde for aldehyde de hydrogenase. Several authors have described an acceleration of ethanol oxidation in the presence of fructose [23,31,36]. According to the reaction mechanism for ADH of Theorell [33] the rate limiting step for the oxidation of ethanol consists in the dissociation of the binary complex of the enzyme and the reduced coenzyme.…”

Section: Discussionmentioning

confidence: 99%

“…Since it has been suggested that alcohol dehydrogenase is also involved in fructose metabolism [19], the effect of pyrazol on fructose metabolism has been examined. It has been reported that fructose given in large doses enhances the rate of ethanol oxidation in man and dog [23,31]. According to Theorell [33] the dissociation of the alcohol dehydrogenase-NADH complex is rate limiting in ethanol oxidation.…”

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confidence: 99%

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Metabolism of Ethanol and Fructose in the Perfused Rat Liver

Papenberg

Wartburg

Aebi³

1970

Enzymol Biol Clin

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Ethanol utilization by the isolated perfused rat liver was studied under various experimental conditions. 1. A linear decrease of the ethanol concentration in the perfusing medium was observed, indicating that ethanol utilization was independent of the ethanol concentration. 2. Inhibition of alcohol dehydrogenase by pyrazol was paralleled by a decrease in ethanol utilization. 3. The uptake of fructose and its conversion to glucose were inhibited by ethanol. Ethanol utilization was diminished in the presence of fructose. 4. Increased ratios of lactate to pyruvate and a-glycerophosphate to dihydroxyacetone phosphate were found during ethanol oxidation. These changes are presumably due to the formation of NADH, although they were not prevented by an inhibition of alcohol dehydrogenase with pyrazol.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Metabolism of Ethanol and Fructose in the Perfused Rat Liver

Papenberg

Wartburg

Aebi³

1970

Enzymol Biol Clin

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“…In der Intensivpflege wird bei der parenteralen Ernghrung Xthanol als Energie- Eingangs wurde bereits auf die sehr hohen Werte ffir fl 60 (Eliminationsrate) bei den dutch Seh/~del-I-Iirn-Traumata immobilisierten somnolenten Patienten hingewiesen. Sie erhielten zwar unter anderem Fructose infundiert, jedoch ist die yon Stuhlfauth et al [5] beriehtete Steigerung der Abbaurate ffir Alkohol um das 1,5--2faehe yon anderen Untersuchern nicht bestgtigt worden [7]. M6glieherweise fiihrt jedoch die Stoffweehselsituation der Intensivpatienten bei parenteraler Ern/~hrung zu einer sehnelleren Reoxydation des NAD/NADH2-Komplexes.…”

Section: Zusammenunclassified

Anflutung und Verteilung von Alkohol bei oraler Resorption

1972

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Flowing Phase and Diffusion o/Ethylalcohol by Oval ResorptionSummary. The lower tolerance to ethylalcohol during the resorptive phase may be attributed to a higher concentration of alcohol in the brain. The cause is the increased concentration of alcohol in the arterial blood --as compared to the peripheral venous blood --and a fast concentration adjustment between the arterial blood and brain-tissue. The arterial-venous difference of alcohol concentration after administration of 0.8 g ethylalcohol (33 W/W% solution, 15 rain absorption) was determined in 5 patients in an intensive care unit. It indicated a maximum of 0.27 -4-0.200/00 . An alcohol concentration of 0.940/00 was reached in the arterial blood and 0.81°/oo in the venous blood. The elimination rate (fl 60) of 0.30 q-0.050/00 was very high. In comparison, an elimination rate (fl 60) was obtained in 5 patients during Halothane anesthesia. It amounted to 0.15 -4-0.02°/oo and was, therefore, within the normal range. Rats did not show reduced ethylalcohol elimination rate under ttalothane either. A possible small reduction in ethylalcohol degradation may be attributed to a competitive restraint of ADtt-activity by Trifluorethanol, which is a Halothane product of metabolism. This seems to be sufficiently considered when using a fi 60 value of 0.10°/o0 for the determination of the previous blood alcohol concentration. Zusammen/assung.

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The Metabolism of Alcohol in Normals and Alcoholics: Enzymes

Wartburg

1971

The Biology of Alcoholism

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Untersuchungen �ber den enzymatischen Alkoholabbau beim Menschen unter besonderer Ber�cksichtigung des Intermedi�rstoffwechsels

Cited by 14 publications

References 14 publications

Metabolism of Ethanol and Fructose in the Perfused Rat Liver

Metabolism of Ethanol and Fructose in the Perfused Rat Liver

Anflutung und Verteilung von Alkohol bei oraler Resorption

The Metabolism of Alcohol in Normals and Alcoholics: Enzymes

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