Flowing Phase and Diffusion o/Ethylalcohol by Oval ResorptionSummary. The lower tolerance to ethylalcohol during the resorptive phase may be attributed to a higher concentration of alcohol in the brain. The cause is the increased concentration of alcohol in the arterial blood --as compared to the peripheral venous blood --and a fast concentration adjustment between the arterial blood and brain-tissue. The arterial-venous difference of alcohol concentration after administration of 0.8 g ethylalcohol (33 W/W% solution, 15 rain absorption) was determined in 5 patients in an intensive care unit. It indicated a maximum of 0.27 -4-0.200/00 . An alcohol concentration of 0.940/00 was reached in the arterial blood and 0.81°/oo in the venous blood. The elimination rate (fl 60) of 0.30 q-0.050/00 was very high. In comparison, an elimination rate (fl 60) was obtained in 5 patients during Halothane anesthesia. It amounted to 0.15 -4-0.02°/oo and was, therefore, within the normal range. Rats did not show reduced ethylalcohol elimination rate under ttalothane either. A possible small reduction in ethylalcohol degradation may be attributed to a competitive restraint of ADtt-activity by Trifluorethanol, which is a Halothane product of metabolism. This seems to be sufficiently considered when using a fi 60 value of 0.10°/o0 for the determination of the previous blood alcohol concentration. Zusammen/assung.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.