Anflutung und Verteilung von Alkohol bei oraler Resorption

Abstract

Flowing Phase and Diffusion o/Ethylalcohol by Oval ResorptionSummary. The lower tolerance to ethylalcohol during the resorptive phase may be attributed to a higher concentration of alcohol in the brain. The cause is the increased concentration of alcohol in the arterial blood --as compared to the peripheral venous blood --and a fast concentration adjustment between the arterial blood and brain-tissue. The arterial-venous difference of alcohol concentration after administration of 0.8 g ethylalcohol (33 W/W% solution, 15 rain absorption) was determined in 5 patients in an intensive care unit. It indicated a maximum of 0.27 -4-0.200/00 . An alcohol concentration of 0.940/00 was reached in the arterial blood and 0.81°/oo in the venous blood. The elimination rate (fl 60) of 0.30 q-0.050/00 was very high. In comparison, an elimination rate (fl 60) was obtained in 5 patients during Halothane anesthesia. It amounted to 0.15 -4-0.02°/oo and was, therefore, within the normal range. Rats did not show reduced ethylalcohol elimination rate under ttalothane either. A possible small reduction in ethylalcohol degradation may be attributed to a competitive restraint of ADtt-activity by Trifluorethanol, which is a Halothane product of metabolism. This seems to be sufficiently considered when using a fi 60 value of 0.10°/o0 for the determination of the previous blood alcohol concentration. Zusammen/assung.