Ultrastructure of an odontogenic myxoma

Simes, Roberto J.; Barros, R E; Klein‐Szanto, Andres J.; Cabrini, R. L.

doi:10.1016/0030-4220(75)90208-x

Cited by 17 publications

(3 citation statements)

References 8 publications

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“…The fibroblastic cell normally capable of demonstrating transferrin, ferritin, a,-ACT and vimentin, as well as collagen, switches over to producing excessive amounts of tnyxoid ground substance and altnost no collagen. According to our results a tnixture of more or less cotnpletely transfortned fibroblasts would explain the heterogeneity of myxotna cells as noted by other authors (2,11,18,19).…”

Section: Discussionsupporting

confidence: 87%

“…Although several authors (2,11,18,19) argued against the existence of two different tumor cell types, we think there definitely is a second type of tumor cell which is morphologically dif-ferent from the spindle cell type. This cell is natned as stellate cell showing immunoreactivities for transferrin, a,-AT, S-100 protein and vimentin, as has been proved by us immunohistochemically.…”

Section: Discussionmentioning

confidence: 56%

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Immunohistochemical investigation in odontogenic myxoma

Takahashi

Fujita

Okabe

1991

J Oral Pathology Medicine

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Three odontogenic myxomas are described immunohistochemically by a panel of poly- and monoclonal antibodies to characterize this tumor type. Three types of odontogenic myxoma cells were discriminated: spindle cells, stellate cells and hyaline cells. Neoplastic cells of myxomas were positively stained for transferrin, ferritin, alpha-1-antichymotrypsin (alpha 1-ACT), alpha-1-antitrypsin (alpha 1-AT), S-100 protein and vimentin; however, neuron specific enolase (NSE), S-100 alpha subunit, S-100 beta subunit, Factor VIII-related antigen (FVIII-AG) and cytokeratin (CK1) were negative. Spindle cells were positive for transferrin, ferritin, alpha 1-ACT, alpha 1-AT, S-100 protein and vimentin. Stellate cells were strongly positive for transferrin, alpha 1-AT, S-100 protein and vimentin. Hyaline cells reacted with alpha 1-ACT and alpha 1-AT. Myxomatous matrix showed negative reaction for all the antibodies used. These results have confirmed that odontogenic myxoma is a tumor of a dual fibroblastic-histiocytic origin.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 56%

Immunohistochemical investigation in odontogenic myxoma

Takahashi

Fujita

Okabe

1991

J Oral Pathology Medicine

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“…They assumed this lesion represented and odontogenic fihrotiia which has undergone myxomatous degcnration. This concept, however, has been abandoned in the course of time as several ultrastructural studies have offered proof that myxoma is a tumor of fibroblasts that are modified in such a sense that they do not form collagen fibrils but a matrix eomposed of glyeosaminoglycans (GAG's) (2)(3)(4)(5)(6)(7)(8)(9). "Myxoblast" is the term oecasionally employed for this modified fibroblast (2,6,7,(9)(10)(11).…”

mentioning

confidence: 99%

Glycosaminoglycans in myxoma of the jaw: a biochemical study

Slootweg

Bos

Straks

1985

J Oral Pathology Medicine

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Myxoma of the jaw is classified as an odontogenic tumor although final proof for an odontogenic origin is lacking. In the present study glycosaminoglycans (GAG's) in the extracellular matrix of a jaw myxoma were analyzed and compared with known data on GAG's in dental tissues. It was noted that the GAG's formed approximately 1% of the total tumor weight and 17% of the dry weight. Hyaluronic acid formed 72.4% of the GAG‐fraction. Neither this high GAG‐content nor the high fraction of hyaluronic acid are found in dental tissues and it is concluded that the myxoma matrix differs from the matrix in dental pulp and periodontal ligament.

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Myxoma of bone in a nonhuman primate

Shalev

Murphy

Fox

et al. 1980

Cancer

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A myxoma of the mandibles in an adult female Macaca mulatta is described. The left mandible was markedly enlarged by the tumor, which extended from the symphysis to the temporomandibular joint. The tumor had extended a short distance across the symphysis into the right mandible. It was composed of a glistening mucinous material. Radiographs of the tumor showed a large expansile radiolucent lesion of the left mandible without soft tissue involvement. Light microscopy demonstrated capillaries, stellate shaped cells with processes up to 15 mu long, very few other cell types, and an amorphous ground substance. Electron microscopic examination revealed similarity to the myxoma of bone of man. The oxytalan fibers discovered in this myxoma have not been found in myxomas before and suggest the tumor is odontogenic in origin. The incidence of spontaneous neoplasia in general and that of spontaneous oral tumors in particular in nonhuman primates are reviewed.

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Ultrastructure of an odontogenic myxoma

Cited by 17 publications

References 8 publications

Immunohistochemical investigation in odontogenic myxoma

Immunohistochemical investigation in odontogenic myxoma

Glycosaminoglycans in myxoma of the jaw: a biochemical study

Myxoma of bone in a nonhuman primate

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