Myxoma of bone in a nonhuman primate

Abstract

A myxoma of the mandibles in an adult female Macaca mulatta is described. The left mandible was markedly enlarged by the tumor, which extended from the symphysis to the temporomandibular joint. The tumor had extended a short distance across the symphysis into the right mandible. It was composed of a glistening mucinous material. Radiographs of the tumor showed a large expansile radiolucent lesion of the left mandible without soft tissue involvement. Light microscopy demonstrated capillaries, stellate shaped cells with processes up to 15 mu long, very few other cell types, and an amorphous ground substance. Electron microscopic examination revealed similarity to the myxoma of bone of man. The oxytalan fibers discovered in this myxoma have not been found in myxomas before and suggest the tumor is odontogenic in origin. The incidence of spontaneous neoplasia in general and that of spontaneous oral tumors in particular in nonhuman primates are reviewed.

A Rare Case of Odontogenic Myxoma in a Dog

“…The location of the tumour, its clinical features, gross appearance and histological findings are, by and large, consistent with the previous such reports in human beings and non-human primates (Shalev et al, 1980;Lo Muzio et al, 1995Park et al, 1996;Hernandez et al, 2001;Oygur et al, 2001). However, in the present case, although a number of residual bony trabeculae and multicystic cavities (Evrard et al, 1997) were found, no odontogenic epithelium or osteocement-like spherical calcified bodies were detected as was the case in some human odontogenic myxomas (Lo Muzio et al, 1996;Oygur et al, 2001).…”

“…Periodontal tumours are fairly common in dogs and cats, and mainly consist of different types of epulides (Jones and Hunt, 1983; Verrstraete et al., 1992). However, odontogenic myxoma arising from periodontal tissue is rare in man (Gorlin et al., 1963; Lo Muzio et al., 1995; Oygur et al., 2001) and even rarer in animals (Shalev et al., 1980; Jones and Hunt, 1983; Chandra et al., 1999). This tumour generally arises from the mesenchyme of teeth including dental papilla, follicle and periodontal ligament (Shafer et al., 1983) and has an increased predilection for mandibles (Hernandez et al., 2001).…”

Neoplasia and Proliferative Disorders of Nonhuman Primates

“…A unique case of peripheral neuropathy associated with an osteosarcoma has been reported in a Japanese monkey (M. fuscata) by Yasuda et al (1990). A primary myxoma of the left mandibular bone has been reported in a rhesus macaque (Shalev et al, 1980) and an osteogenic sarcoma has been described in a stumptailed macaque (Chesney and Allen, 1972). Bony tumors in New World monkeys are more uncommon; however there are several reports of osteosarcoma arising in the long bones of squirrel monkeys (Reed and Garman, 1977;Knight and Wadsworth, 1981) as well as the report of a chondrosarcoma in a squirrel monkey (Chalifoux, 1993) (Figure 6.19).…”

Odontogenic Fibromyxoma in a Cat: First Confirmed Case in This Species

“…3,30,32,34 Histopathologically, they maintain a similar appearance to the pulpal ectomesenchyme across species. 1,22,28,32,35,36 In a minority of cases, odontogenic epithelium is noted on histopathology. 1,2,28,30,34,36,37 Odontogenic myxomas are also known as odontogenic fibromyxomas or odontogenic myxofibromas, particularly if a subjectively larger amount of collagen is noted on histopathology.…”