Immunohistochemical investigation in odontogenic myxoma

Takahashi, Hiroshi; Fujita, Shuichi; Okabe, Haruo

doi:10.1111/j.1600-0714.1991.tb00903.x

Cited by 34 publications

(17 citation statements)

References 31 publications

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“…The given epicentres for pathogenesis are still a dilemma for origin and yet to be proved because some studies signify that OM stroma has no resemblance to dental follicle and it may be a dual fibroblast-histiocytic origin 15. This duality arises because of the hypothetical origin of fibroblasts to produce mucopolysaccharides which mimic myxoid tumours histopathologically 16.…”

Section: Discussionmentioning

confidence: 99%

Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology

Bahl¹,

Raju²,

Shah

et al. 2016

BMJ Case Reports

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Myxoma of the jaws which was first described by Thoma and Goldman in 1947 is a rare neoplasm and its rate of prevalence and incidence is not available. Myxoma term, according to 1992 WHO classification, is used along with odontogenic myxoma (OM) and myxofibroma. There are two forms of myxomas or fibromyxomas that are recognised in head and neck region: one is derived from the facial skeleton and the other is derived from the soft tissue. Most of the OM are located intraosseously, but peripheral ones are also recognised. OM behaves differently from myxomatous tumours of long bones, which recur more often and may transform into malignancy. A majority of these lesions occur between 2nd and 4th decade. In the pathogenesis of OM, dental papilla, dental follicle and periodontal ligament tissues have been implicated as possible 'germ centres'. This case describes an uncommon finding of central odontogenic fibromyxoma, throwing light on its epidemiology, clinical, histopathology, molecular and treatment aspects.

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Section: Discussionmentioning

confidence: 99%

Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology

Bahl¹,

Raju²,

Shah

et al. 2016

BMJ Case Reports

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“…8,12 Immunohistochemical results with S-100 protein are conflicting. In a small number of reports, S-100 positivity has been claimed in odontogenic myxoma, 8,12 a finding that has been disputed. 9 Unlike in humans, 8,9 the tumor cells in this filly were negative for actin, although arterioles and arteries within the tumor stained for actin.…”

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confidence: 99%

Odontogenic Myxoma of the Mandible in a Filly

1999

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Odontogenic tumors are uncommon in domestic animals and have been broadly classified as epithelial or mesodermal (stromal) odontogenic tumors. 4 Other than the canine fibromatous epulis, stromal neoplasms are very rare in animals. The 2 main types of mesodermal tumors are odontogenic myxoma (fibromyxoma) and cementoma. 4 In the only report of an odontogenic myxoma in a domesticated animal, no details were given. 3 This present report includes a light microscopic, ultrastructural, and immunohistochemical description of an odontogenic myxoma in the mandible of a horse.A 1.5-year-old mixed-breed filly was referred to the Veterinary Medicine Teaching Hospital, University of Florida, Gainesville, because of marked left mandibular swelling, profuse salivation, and inability to eat or drink. On physical examination, a painful, malodorous mass was present on the left mandible. Radiologic examination revealed malalignment of the horizontal ramus of the left mandible and expansion of the ramus by a mottled area of uneven radiopacity. Because of a guarded prognosis and financial constraints, the filly was euthanized.At necropsy, the only abnormality was a glistening, bosselated, tan and off-white mass (12 ϫ 11 cm) in the horizontal ramus of the left mandible, protruding into the oral cavity (Fig. 1). The surface of the mass was partially covered by strands of green fibrous ingesta, with multifocal areas of necrosis and hemorrhage. The mass completely replaced 2 premolar teeth. On radiologic examination of the dissected mandible, the mass had multiloculated radiolucency and was expanding and destroying the mandibular bone (Fig. 2). On cut surface, the mass was variably firm, glistening, and offwhite to light tan. Sagittal section of the mandibular ramus revealed extensive invasion and replacement of the mandibular bone by the mass. A thin band of remnant bone was present on the ventral aspect of the ramus.Tissue samples obtained at necropsy were fixed in 10% neutral buffered formalin, embedded in paraffin, and stained with hematoxylin and eosin. Paraffin-embedded sections were histochemically stained with alcian blue at pH 2.6 for sulfated and nonsulfated glycosaminoglycans (GAG) and at pH 1.0 for sulfated GAG. Formalin-fixed, paraffin-embedded sections were immunohistochemically stained for localization of cytokeratin (rabbit polyclonal antibody against cytokeratins 5, 6, 8, 13, and 16), vimentin, S-100 protein, lysozyme, and actin a using an avidin-biotin-peroxidase complex (ABC) method. b For ultrastructural examination, sam-

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“…6 Histologically, however, all myxomas are very similar and have no characteristic features to distinguish them. Differentiation of neural and odontogenic myxomas is problematic and there have been occasional reports of S 100 positivity in odontogenic myxoma.8 10 We have therefore performed an immunocytochemical investigation of odontogenic myxomas, intramuscular and cardiac myxomas, and a variety of normal myxoid tissues with which myxoma is frequently confused by those unfamiliar with odontogenic lesions. "-"' The aims were to ascertain the diagnostic value of routine S100 and a-smooth muscle actin (o-SMA) immunostaining in these tissues and by cytokeratin 19 staining to obtain further circumstantial evidence that the epithelium in jaw myxomas is odontogenic.…”

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confidence: 99%

S100, alpha-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomas.

Lombardi

Lock

Samson

et al. 1995

Journal of Clinical Pathology

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Aims-To compare the expression of S100 protein, a-smooth muscle actin (a-SMA) and keratin 19 in odontogenic myxomas and non-odontogenic myxoid lesions. Methods-Formalin fixed, paraffin wax embedded tissue from seven odontogenic myxomas, three soft tissue myxomas, six hyperplastic myxoid dental follicles, two intramuscular myxomas, 12 cardiac myxomas, and seven normal dental follicles were examined immunocytochemically for S100 protein, a-SMA and cytokeratin 19 using the Streptavidin-biotin method. Results-A minority of odontogenic myxomas (three of seven) were positive for S100 and the staining was of moderate intensity and in all myxofibroblasts. Soft tissue myxomas, normal dental follicles, intramuscular myxomas, and most enlarged myxoid follicles were negative. In the cardiac myxomas the cells forming cords and islands were positive in approximately half (seven of 12), but the dispersed steilate myxoblasts were positive in only two cases. A population of cells in all the odontogenic myxomas and hyperplastic dental follicles contained a-SMA, but such cells were sparse in cardiac myxomas and present in only four cases. Cytokeratin 19 was present in odontogenic epithelium of odontogenic myxoma and follicles.Conclusions-A minority of odontogenic myxomas, but not other oral myxoid lesions, may express S100 protein and this could cause difficulty distinguishing myxoma from myxoid nerve sheath tumours. Sparse myofibroblastic cells occurred in all types ofmyxoma tested. The epithelium sometimes found within jaw myxomas expresses cytokeratin 19 and this is consistent with an odontogenic origin. (J7 Clin Pathol 1995;48:759-762)

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Immunohistochemical investigation in odontogenic myxoma

Cited by 34 publications

References 31 publications

Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology

Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology

Odontogenic Myxoma of the Mandible in a Filly

S100, alpha-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomas.

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