Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology

Abstract

Myxoma of the jaws which was first described by Thoma and Goldman in 1947 is a rare neoplasm and its rate of prevalence and incidence is not available. Myxoma term, according to 1992 WHO classification, is used along with odontogenic myxoma (OM) and myxofibroma. There are two forms of myxomas or fibromyxomas that are recognised in head and neck region: one is derived from the facial skeleton and the other is derived from the soft tissue. Most of the OM are located intraosseously, but peripheral ones are also recognised. OM behaves differently from myxomatous tumours of long bones, which recur more often and may transform into malignancy. A majority of these lesions occur between 2nd and 4th decade. In the pathogenesis of OM, dental papilla, dental follicle and periodontal ligament tissues have been implicated as possible 'germ centres'. This case describes an uncommon finding of central odontogenic fibromyxoma, throwing light on its epidemiology, clinical, histopathology, molecular and treatment aspects.

Fibromyxoma of mandibular gingiva: a case study

“…The prevention of a relapse is strongly related to the complete resection of the lesion. The patient should be monitored for at least 2-5 years after surgery because of a high relapse rate of 25% during this period [15,[17][18][19]. For the observed case, because of the location of the soft tissue, we carried out a large resection of the tumor with an alveolar vacuum and the avulsion of the teeth embedded in the tumor.…”

Odontogenic fibromyxoma: A case report in myasthenia gravis patient and review of the literature

“…When the literature was searched for the incidence of odontogenic fibromyxoma, no single incidence rate was found. Myxomas constitutes approximately 1–17.7 % of all odontogenic tumors and odontogenic fibromyxomas represent a very small part of all myxomas and their prevalence varies from 0.04 % to 3.7 % [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] .…”

“…Recent studies are considered to originate from primitive mesenchymal structures and are thought to arise from bone, tooth germ, or odontogenic tissues such as dental papilla, dental follicle or periodontal ligament. For this reason, we can say that all myxomas seen in the jaws are of odontogenic origin [7] , [8] , [9] , [10] , [11] , [13] , [14] , [15] , [16] , [17] , [20] , [23] , [24] , [25] , [26] , [27] , [28] , [29] .…”

“…It was observed that it peaked in the third decade. [2] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [16] , [17] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] . It is rarely seen in adults over 50 and children under 10 years of age [1] , [8] , [9] , [10] , [11] , [14] , [20] , [21] , [23] , [25] .…”

“…It is vary from small unilocular radiolucent lesions to large multilocular radiolucent lesions which have mostly well-defined borders. Multilocular radiolucent images; honeycomb, soap bubble, tennis racket, wispy and spider web in appearance [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [20] , [21] , [23] , [25] . Most of them are multilocular and the most characteristic radiographic feature is the “tennis racquet” appearance [11] , [12] , [13] .…”