S100, alpha-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomas.

Lombardi, Tommaso; Lock, Claire; Samson, Jacky; Odell, Edward

doi:10.1136/jcp.48.8.759

Cited by 55 publications

(42 citation statements)

References 21 publications

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“…However, immunohistochemical studies have been inconsistent and have not been able to confirm pulp tissue origin (33)(34)(35). Odontogenic myxoma …”

Section: Odontogenic Myxomamentioning

confidence: 99%

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

2002

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Odontogenic cysts that can be problematic because of recurrence and/or aggressive growth include odontogenic keratocyst (OKC), calcifying odontogenic cyst, and the recently described glandular odontogenic cyst. The OKC has significant growth capacity and recurrence potential and is occasionally indicative of the nevoid basal cell carcinoma syndrome. There is also an orthokeratinized variant, the orthokeratinized odontogenic cyst, which is less aggressive and is not syndrome associated. Ghost cell keratinization, which typifies the calcifying odontogenic cyst, can be seen in solid lesions that have now been designated odontogenic ghost cell tumor. The glandular odontogenic cyst contains mucous cells and ductlike structures that may mimic central mucoepidermoid carcinoma. Several odontogenic tumors may provide diagnostic challenges, particularly the cystic ameloblastoma. Identification of this frequently underdiagnosed cystic tumor often comes after one or more recurrences and a destructive course. Other difficult lesions include malignant ameloblastomas, calcifying epithelial odontogenic tumor, squamous odontogenic tumor, and clear-cell odontogenic tumor. Histologic identification of myxofibrous lesions of the jaws (odontogenic myxoma, odontogenic fibroma, desmoplastic fibroma) is necessary to avoid the diagnostic pitfall of overdiagnosis of similar-appearing follicular sacs and dental pulps. Fibroosseous lesions of the jaws show considerable microscopic overlap and include fibrous dysplasia, ossifying fibroma, periapical cementoosseous dysplasia, and low-grade chronic osteomyelitis. The term fibrous dysplasia is probably overused in general practice and should be reserved for the rare lesion that presents as a large, expansile, diffuse opacity of children and young adults. The need to use clinicopathologic correlation in assessing these lesions is of particular importance. Central giant cell granuloma is a relatively common jaw lesion of young adults that has an unpredictable behavior. Microscopic diagnosis is relatively straightforward; however, this lesion continues to be somewhat controversial because of its disputed classification (reactive versus neoplastic) and because of its management (surgical versus. medical). Its relationship to giant cell tumor of long bone remains undetermined.

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“…However, immunohistochemical studies have been inconsistent and have not been able to confirm pulp tissue origin (33)(34)(35). Odontogenic myxoma …”

Section: Odontogenic Myxomamentioning

confidence: 99%

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

2002

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“…8,9,12 In addition to vimentin, neoplastic cells in this filly also stained positively for S-100 and lysozyme, which has been reported in humans. 8,12 Immunohistochemical results with S-100 protein are conflicting. In a small number of reports, S-100 positivity has been claimed in odontogenic myxoma, 8,12 a finding that has been disputed.…”

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confidence: 92%

“…8,12 Immunohistochemical results with S-100 protein are conflicting. In a small number of reports, S-100 positivity has been claimed in odontogenic myxoma, 8,12 a finding that has been disputed. 9 Unlike in humans, 8,9 the tumor cells in this filly were negative for actin, although arterioles and arteries within the tumor stained for actin.…”

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confidence: 99%

Odontogenic Myxoma of the Mandible in a Filly

1999

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Odontogenic tumors are uncommon in domestic animals and have been broadly classified as epithelial or mesodermal (stromal) odontogenic tumors. 4 Other than the canine fibromatous epulis, stromal neoplasms are very rare in animals. The 2 main types of mesodermal tumors are odontogenic myxoma (fibromyxoma) and cementoma. 4 In the only report of an odontogenic myxoma in a domesticated animal, no details were given. 3 This present report includes a light microscopic, ultrastructural, and immunohistochemical description of an odontogenic myxoma in the mandible of a horse.A 1.5-year-old mixed-breed filly was referred to the Veterinary Medicine Teaching Hospital, University of Florida, Gainesville, because of marked left mandibular swelling, profuse salivation, and inability to eat or drink. On physical examination, a painful, malodorous mass was present on the left mandible. Radiologic examination revealed malalignment of the horizontal ramus of the left mandible and expansion of the ramus by a mottled area of uneven radiopacity. Because of a guarded prognosis and financial constraints, the filly was euthanized.At necropsy, the only abnormality was a glistening, bosselated, tan and off-white mass (12 ϫ 11 cm) in the horizontal ramus of the left mandible, protruding into the oral cavity (Fig. 1). The surface of the mass was partially covered by strands of green fibrous ingesta, with multifocal areas of necrosis and hemorrhage. The mass completely replaced 2 premolar teeth. On radiologic examination of the dissected mandible, the mass had multiloculated radiolucency and was expanding and destroying the mandibular bone (Fig. 2). On cut surface, the mass was variably firm, glistening, and offwhite to light tan. Sagittal section of the mandibular ramus revealed extensive invasion and replacement of the mandibular bone by the mass. A thin band of remnant bone was present on the ventral aspect of the ramus.Tissue samples obtained at necropsy were fixed in 10% neutral buffered formalin, embedded in paraffin, and stained with hematoxylin and eosin. Paraffin-embedded sections were histochemically stained with alcian blue at pH 2.6 for sulfated and nonsulfated glycosaminoglycans (GAG) and at pH 1.0 for sulfated GAG. Formalin-fixed, paraffin-embedded sections were immunohistochemically stained for localization of cytokeratin (rabbit polyclonal antibody against cytokeratins 5, 6, 8, 13, and 16), vimentin, S-100 protein, lysozyme, and actin a using an avidin-biotin-peroxidase complex (ABC) method. b For ultrastructural examination, sam-

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“…In this regard, an odontogenic myxoma should ideally not express S100 or CD34 (except in vasculature) or any of the muscle markers, or CD68. However, S100 expression has been reported, a finding which may compound difficulties in distinction from myxoid peripheral nerve sheath tumors [45]. Furthermore, it has been suggested that the identification of S100 expressing small nerve fibres may indicate an enlarged dental follicle rather than an odontogenic myxoma [45].…”

Section: Odontogenic Myxomamentioning

confidence: 99%

“…An epithelial component is unusual, but when present expressed CK14, and showed a very low proliferation fraction. There is disagreement in the literature over expression of CK19 [44,45]. The main issue in the differential diagnosis of odontogenic myxoma is distinction from myxoid variants of other tumors, including myxoid neural (e.g.…”

Section: Odontogenic Myxomamentioning

confidence: 99%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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S100, alpha-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomas.

Cited by 55 publications

References 21 publications

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

Odontogenic Myxoma of the Mandible in a Filly

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

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