Glycosaminoglycans in myxoma of the jaw: a biochemical study

Slootweg, Pieter J.; Bos, T. van den; Straks, W.

doi:10.1111/j.1600-0714.1985.tb00497.x

Cited by 35 publications

(16 citation statements)

References 25 publications

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“…The evaluation of the presence of vimentin, an intermediate filament of the cytoskeleton characterises mesenchymal tissues, thus also myxomas [1]. Fibromyxomas also contain a high amount of hyaluronic acid [32]. …”

Section: Discussionmentioning

confidence: 99%

Odontogenic Fibromyxoma of the Maxilla: A Case Report and Review of the Literature

Dietrich

Papaemmanouil

Koloutsos

et al. 2011

Case Reports in Medicine

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Fibromyxoma represents a rare benign neoplasm that mostly affects the posterior region of the mandible. Here, we report the case of a 46-year-old male with a swelling of the right maxilla. After proper diagnosis, he was treated with enucleation and curettage of the tumor. The defect was filled with a pedicled buccal fat pad flap. The mesenchymal origin from the dental follicle of the fibromyxoma is the most plausible explanation. Radiological examination with MRI, CT, and conventional radiography contributes to the differential diagnosis from other benign tumors, such as the ameloblastoma. Its management is surgical and comprises enucleation and curettage or en bloc resection. Patients must be monitored for at least two years postoperatively in order to diagnose possible recurrence. According to the literature, the maxilla is a rare location of a fibromyxoma and, to our knowledge, our case is the 30th presented case of a fibromyxoma of the maxilla.

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Section: Discussionmentioning

confidence: 99%

Odontogenic Fibromyxoma of the Maxilla: A Case Report and Review of the Literature

Dietrich

Papaemmanouil

Koloutsos

et al. 2011

Case Reports in Medicine

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“…This resemblance to the mesenchyme of a developing tooth or the periodontal ligament has led investigators to believe that these tissues give rise to the tumor [5]. However, some studies have found that the cells in the matrix of the odontogenic myxoma are different from the ectomesenchymal tissues of a developing tooth [6,7]. In addition, though it is rare, this tumor does occur in extragnathic bones [2,3,8].…”

Section: Introductionmentioning

confidence: 99%

A Case of Odontogenic Myxoma with Unusual Histological Features Mimicking a Fibro-Osseous Process

Lin

Basile

2010

Head and Neck Pathol

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Odontogenic myxoma is a rare benign but locally aggressive odontogenic tumor. This report describes a case of odontogenic myxoma producing diffusely dispersed calcified products in a pattern reminiscent of a fibro-osseous lesion of the jaw. Differential diagnoses for myxoid lesions of the jaws also are discussed. This paper highlights how an odontogenic myxoma can produce a large amount of calcified products to mimic a fibro-osseous process.

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“…The tumor is rich in extracellular matrix (ECM) represented by type I collagen, fibronectin, tenascin, chondroitin sulfate and especially abundant in hyaluronic acid (3)(4)(5). This excessive ECM production has been implicated in the invasive behaviour of the tumor.…”

Section: Introductionmentioning

confidence: 99%

Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro

et al. 2008

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Odontogenic myxoma is a benign neoplasm, which presents local invasiveness and tendency for recurrence. Matrix metalloproteinases (MMPs) 2 and 9 are involved in tumor invasion. Thus, the aim of this study was to analyze the expression and activity of these MMPs in odontogenic myxoma in vivo and in vitro. Three cases of odontogenic myxoma and cultured cells derived from this tumor (Mix1 cell line) were used. The detection and activity of two M M P s ( 2 a n d 9 ) w e re p e r fo r m e d b y immunohistochemistry in formalin-fixed, paraffinembedded sections of odontogenic myxoma and immunofluorescence of the cultured cells and, by gelatin zymographic analysis of Mix1 conditioned media, respectively. MMPs 2 and 9 were detected in vivo and in vitro. The zymographic assay detected latent MMP-2 as well as latent and active MMP-9. Based on our findings, we suggest that MMPs may be involved in local invasiveness of the odontogenic myxoma. MMP-9 is not only secreted by odontogenic myxoma but also has enzyme activity with no further stimulation. Other MMPs were not analyzed; however, our results suggest that the invasive behaviour of odontogenic myxoma could be related at least to MMP-9. (J. Oral Sci. 50, [187][188][189][190][191][192] 2008)

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Glycosaminoglycans in myxoma of the jaw: a biochemical study

Cited by 35 publications

References 25 publications

Odontogenic Fibromyxoma of the Maxilla: A Case Report and Review of the Literature

Odontogenic Fibromyxoma of the Maxilla: A Case Report and Review of the Literature

A Case of Odontogenic Myxoma with Unusual Histological Features Mimicking a Fibro-Osseous Process

Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro

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