Ueber Curarin

Abstract

I m Jalire 1865 erschien eine Arbeit von Dr. P r e y e r *),

Regioselective Synthesis of Biologically Important Scaffold Spiro [Indole- Perimidines]: An Antitumor Agents

“…1 Table 2). 13 C NMR spectrum of 4a showed absence of signals at 149.4 (C-NH 2 ), 159.8 (C=N) and presence of signals at 87.9 (spiro carbon), and 168.4(C=O) also favoured the formation of spiro derivatives 4. In mass spectrum of 4a molecular ion peak was observed at 287[M + ] (5.2) corresponding to its molecular weight.…”

“…Characteristic absorptions at 3380, 3244 (NH 2 ), 3174 (NH) and 1720 (C=O) in IR spectrum of compound 3a confirmed the formation of shiff base [17] derivatives. I H NMR spectrum of 3 showed peaks at d 7.04-7.40(m, 12H, Ar-H and NH 2 ) and 9.47 (s, 1H, NH) and 13 2) corresponding to its molecular weight ( Table 2).…”

“…1H perimidine and its derivatives are known to possess various biological activities like antitumor [1], DNA binding [2], cytotoxic [3], anticancer [4], antineoplastic [5], CRF antagonist [6], multidrugs resistant for tumor cell [7], antibacterial [8], non peptide corticotropin release factor antagonist [9], oxidants [10] anticonvulsant [11], surface-active agents [12] and dyes [13].…”

“…Though these potential drug molecules are known since 1909 by the reaction of 1,8-diaminonaphthalene with carbon disulfide [13], the X-ray crystal structure of the basic skeleton is not yet known. The simplest literature method for the synthesis of perimidine is to reflux 1,8-diaminonaphthalene and formic acid in ethanol under N 2 atmosphere [2].…”