Regioselective Synthesis of Biologically Important Scaffold Spiro [Indole- Perimidines]: An Antitumor Agents

Abstract

Regioselective synthesis of spiro [indole -3(3H), 2 (3H)perimidine]2 (1H)one (4a-e) for potential application in cancer treatment \ under conventionally and microwave irradiation using different solvents/solid support has been studied. A judicious choice of the reaction conditions allowed the titled product 4a-e to be generated in excellent yields.

Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-N,N-ketals: Reactions of Naphthalene-1,8-diamine with Ninhydrin and Isatin

“…The reaction of isatin with naphthalene-1,8-diamine has also been described in the literature [20,21,22,23]. Here, we reinvestigated this reaction under the conditions involving the use of acetic acid as the solvent in the presence of a catalytic amount of p -toluenesulfonic acid.…”

“…291–293 °C [23]); 1 H-NMR (DMSO-d 6 ): δ 11.25 (1H, s), 8.20 (1H, d, J = 7.2), 8.13 (1H, d, J = 6.7), 7.55 (1H, t, J = 6.8), 7.48 (1H, d, J = 7.4), 7.37 (2H, t, J = 6.1), 7.35 (1H, d, J = 8.0), 7.17 (1H, t, J = 7.1), 7.07 (1H, d, J = 8.0), 6.98 (1H, d, J = 6.8); 13 C-NMR (DMSO-d 6 ): 95.3, 113.9, 114.4, 115.2, 116.9, 121.9, 122.2, 122.6, 127.0, 127.8, 133.3, 133.9, 137.5, 139.3, 146.9, 148.2, 174.8. IR(KBr): 1699 cm −1 ; MS m/z 285 (M + ); Anal.…”