Über trans‐Lipoide

Kaufmann, E.; Bandyopadhyay, Chandrakanta

doi:10.1002/lipi.19650671202

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…In agreement with the results obtained with other tissues (G. Billek & F. Strauch, unpublished work;Coots, 1964) showing the absence of mechanisms adversely influencing the transport of trans-fatty acids, no restrictions on the uptake of trans-fatty acids were observed in the perfused chicken liver. Other workers have postulated a membrane barrier in brain tissue (Kaufmann & Bandyopadhyay, 1965) absorption of trans-fatty acids. The incorporation of the labelled fatty acids into liver triglycerides and phospholipids and the release of labelled lipid into the perfusate are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid

Bickerstaffe

Annison

1970

Biochemical Journal

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Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some release of labelled lipid into the perfusate was observed. The cis-fatty acids were more readily incorporated into triglycerides than phospholipids, the reverse being true of the trans-fatty acids. Examination of the intramolecular distribution of fatty acids in triglycerides showed that the trans-fatty acid and stearate mainly occupied the 1- and 3-positions, and cis-fatty acids the 2-position. In the phospholipids phosphatidylcholine and phosphatidylethanolamine the trans-fatty acids again behaved like stearic acid and favoured the 1-position. No evidence was obtained of atypical patterns of uptake or metabolism of the trans-fatty acids.

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Section: Resultsmentioning

confidence: 99%

Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid

Bickerstaffe

Annison

1970

Biochemical Journal

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“…mann and Bandyopadhyay (19) concluded from analyses of human brain obtained at autopsy that brain lipids remain free of transfatty acids; however, their data showed that trans-acids actually represented 0.05-0.8% of the total fatty acids of brain lipids. It is clear also from our analyses that trans-acids are not excluded from human brain.…”

Section: Until Recently a Conclusion Reached Bymentioning

confidence: 96%

The influence oftrans‐acids on desaturation and elongation of fatty acids in developing brain

Cook

1981

Lipids

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trans-Monounsaturated acids account for up to 3% of the total octadecenoic acyl chains of human brain lipids. To investigate the influence of trans-acids on desaturation and chain elongation of fatty acids, in vitro and in vivo experiments with rat brain were performed. In the in vitro assays of delta 9 desaturation, delta 6 desaturation and chain elongation, trans,trans-dienoic acid was inhibitory, particularly to chain elongation. Slight differences between the inhibitory effects of trans-monoenoic acids and their cis-isomers were observed. In an in vivo model, unlabeled fatty acid (stearate, oleate, elaidate, linoleate, linoelaidate, arachidonate, or trans-monoene from margarine) was injected simultaneously with [1-14C] linoleic acid into the brains of suckling rats. Linoelaidate and oleate inhibited desaturation and elongation of linoleate, whereas elaidate, stearate and trans-monoene from margarine were stimulatory. While the demonstration of differences between cis and trans monenic isomers required relatively high levels of the test acids, it appears that trans-acids can influence desaturation and elongation enzymes that lead to acyl chain modification in the central nervous system.

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Lipoide tierischer Organ‐ und Depotfette in Abhängigkeit von der Fütterung I: trans‐Fettsäuren in Kälber‐ und Schweinefetten

Kaufmann¹,

Mankel²

1966

Fette, Seifen, Anstrichm.

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a u f n z a n n und Dr. A . M a n k e l nus der Bzindesnnrtnlt fiir Fettforschung, Munster ( W e s t f . ]In Organ-und Depotfetten van Kalbern und Schweinen wurde der Cehalt an trans-ungesattigten Fettsauren sowie deren Verteilung auf Neutralfett-und Phosphatid-Fraktionen untersucht. Die Tiere waren mit definierten Futtermischungen, die teils gehartetes Fett enthielten. teils frei davon waren, aufgezogen warden. Die Ergebnisse der Untersuchungen sind aus der Zusammenfassung am SchluR der Arbeit zu ersehen. Dietary Fat and the trans-Unsaturated Fatty Acids in Bovine and Porcine Tissues of Heart, Liver and Kidney and Depot Fats from different Localities within the same AnimalThe content of trans-unsaturated fatty acids in lipids of heart, liver and kidney and depot fats from different localities within the same animal (visceral, pericardial, perinephric, extrahepatic, subcutaneous and/or back fat and fat attached to ribs) of calves and pigs, fed a basal diet without trans-unsaturated fatty acids or fed a hardened fat diet, was determined by IR-spectrography. The lipids of heart, kidney and liver were separated by Silica Gel G column chromatography in cholesterol ester, neutral lipids dnd phospholipid fractions. The trans-unsaturated fatty acids of each were determined.D i e weite Verbreitung trans-isomerer Fettsauren in der N a t u r u n d ihre E n t s t e h u n g bei der industriellen Verarbeitung von Fetten veranlai3te uns, i m Interesse biochemischer und ernahrungsphysiologischer, a b e r auch technisch-chemischer F r a g e n , f r u h e r e Untersuchungen auf breiter Basis fortzusetzen. I m Z u s a m m e n h a n g mit analytischen P r o b l e m e n der IRu n d G L C -A n a l y s e w u r d e in m e h r e r e n Arbeiten bereits der Einflui3 der Nahrung auf d i e Lipoide tierischer u n d menschlicher Milch, sowie der Depot-u n d O r g a n f e t t e diskutiert I . Nachstehend berichten wir iiber den Einflui3 der Fiitterung, insbesond e r e trans-haltigen Futters, auf d i e Z u s a m m e n s e t z u n g der Lipoide v o n Kalbern u n d Schweinen.Die Versuche wurden in Z u s a m m e n a r b e i t m i t dem Institut f u r Tierzucht und Tierfiitterung der U n i v e r s i t a t Bonn :F:t durchgefiihrt.

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Über trans‐Lipoide

Cited by 7 publications

References 31 publications

Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid

Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid

The influence oftrans‐acids on desaturation and elongation of fatty acids in developing brain

Lipoide tierischer Organ‐ und Depotfette in Abhängigkeit von der Fütterung I: trans‐Fettsäuren in Kälber‐ und Schweinefetten

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