ÜBER DAS VORKOMMEN VON CUMARIN–DERIVATEN IM KRAUT VON<i>ARTEMISIA ABROTANUM L.</i>

Schmersahl, P.

doi:10.1055/s-0028-1100042

Cited by 11 publications

(4 citation statements)

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“…Although within the Compositae these coumarins are not so rare, aesculetin and scopolin has never been found previously in the genus Santolina. Aesculetin has already been isolated from such diverse genera as Artemisia 14 and Bidens, 15 while scopolin has been described in Artemisia 14 and Anthemis. 16 The spectral data of compound 4 revealed its identity as 6-hydroxy-7-methoxycoumarin (scopoletin).…”

mentioning

confidence: 99%

Antiinflammatory Activity of Coumarins from Santolina oblongifolia

et al. 1996

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Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.

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confidence: 99%

Antiinflammatory Activity of Coumarins from Santolina oblongifolia

et al. 1996

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“…Some coumarins were isolated (2)(3)(4). A reinvestigation of the aerial parts, collected near Agri, Turkey, affordedin addition to the coumarins isolated previously (3, 4) -a coumarin linked with a sesquiterpene moiety (1), which has been reported from an Achillea species (2), as well as the bisabololoxide derivatives 2 and 3.…”

Section: Methodsmentioning

confidence: 95%

α-Bisabololoxide Derivatives fromArtemisia abrotanum

Meriçli¹,

Çubukçu²,

Jakupovic³

et al. 1988

Planta Med

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“…The needles crystalline of IF is predominantly present in a white to yellow color, while it is reported as colorless in some studies, possessing a melting point of 145-150 • C [38][39][40]. The history of isolation and identification of IF dates back to 1937 from the bark of the ash tree (Fraxinus exelsior, Oleaceae) by Spath and Jerzmanowska [41,42]. Since then, this compound has been isolated from numerous plant families including Apiaceae, Asteraceae, Oleaceae, Rubiaceae, etc.…”

Section: Natural Sourcesmentioning

confidence: 99%

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

et al. 2020

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Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources of IF, which, among them, Eleutherococcus and Fraxinus are the well-known genera in which IF could be isolated/extracted from their species. Considering the complex pathophysiological mechanisms behind some diseases (e.g., cancer, neurodegenerative diseases, and heart diseases), introducing IF as a potent multi-target agent, which possesses several herbal sources and the multiple methods for isolation/purification/synthesis, along with the unique pharmacokinetic profile and low levels of side effects, could be of great importance. Accordingly, a comprehensive review was done without time limitations until February 2020. IF extraction methods include microwave, mechanochemical, and ultrasound, along with other conventional methods in the presence of semi-polar solvents such as ethyl acetate (EtOAc). In addition to the isolation methods, related synthesis protocols of IF is also of great importance. From the synthesis point of view, benzaldehyde derivatives are widely used as precursors for IF synthesis. Along with the methods of isolation and biosynthesis, IF pharmacokinetic studies showed hopeful in vivo results of its rapid absorption after oral uses, leading to different pharmacological effects. In this regard, IF targets varieties of inflammatory mediators including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs). thereby indicating anticancer, cardioprotective, and neuroprotective effects. This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.

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ÜBER DAS VORKOMMEN VON CUMARIN–DERIVATEN IM KRAUT VONARTEMISIA ABROTANUM L.

Cited by 11 publications

References 0 publications

Antiinflammatory Activity of Coumarins from Santolina oblongifolia

Antiinflammatory Activity of Coumarins from Santolina oblongifolia

α-Bisabololoxide Derivatives fromArtemisia abrotanum

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

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