Antiinflammatory Activity of Coumarins from <i>Santolina oblongifolia</i>

Silván, A. M.; Abad, María J. F.; Bermejo, Paulina; Söllhuber, Mónica; Villar, A.

doi:10.1021/np960422f

Cited by 111 publications

(59 citation statements)

References 22 publications

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“…7-Methoxycoumarin (herniarin, 4), a bioactive coumarin derivative, has shown several important biological activities (Askari et al 2009), including marked anti-inflammatory activity, as an inhibitor of the eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages (Silván et al 1996).…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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Context The genus Anthemis L. (Asteraceae) comprises about 195 species which are widely used in the pharmaceutical, cosmetic and food industries. Objective Anthemis mirheydari Iranshar, an endemic plant from Iran, was investigated for its cytotoxic properties and chemical constituents. Materials and methods The whole parts of the plant (320 g) were extracted by dichloromethane and methanol for four days, successively. The cytotoxic activity of both dichloromethane and methanol extracts were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric methods against three human cancer cell lines including LS180, MCF-7 and MOLT-4. Different concentrations (10-100 mg/mL) of the plant extracts were tested to obtain IC 50 values. The dichloromethane extract of A. mirheydari was subjected to silica gel-column and thin layer chromatography for purification of its chemical constituents and the isolated compounds were further tested against MOLT-4 cells. The structures of the pure compounds were elucidated using different spectral data including nuclear magnetic resonance and electron impact mass spectra. Results The IC 50 values of the dichloromethane extract were 30.8 ± 6.7, 25.2 ± 6.5 and 8.6 ± 1.1 mg/mL (means ± standard error) for the above-mentioned cell lines, respectively. Two triterpenoids, taraxasterol (1) and pseudotaraxasterol (2), one sterol, b-sitosterol (3) and one coumarin, 7-methoxycoumarin (4) were isolated from the extract. The IC 50 of the mixture of compounds 1 and 2 as well as compounds 3 and 4 were higher (4100 mM) than that reported for the dichloromethane extract against MOLT-4 cells. Conclusion The dichloromethane extract was the most active one among the tested material.ARTICLE HISTORY

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Section: Resultsmentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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“…Coumarins and their derivatives have been found to exhibit a variety of biological and pharmacological activities and have raised considerable interest because of their potential beneficial effects on human health 11 . They have been reported to possess among others: antibiotic 12 , antibacterials 13 , antitumor 14 , antiviral agents [15][16][17] , anticoagulants 18,19 , against psoriasis 20 , antioxidant 21 , anticancer 22,23 , anti-inflammatory [24][25][26] , analgesic 27 and…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

Sökmen

Aydin

Gumus

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…No cytotoxicity was apparent when the concentration of a coumarin derivative was less than 1:0 Â 10 À4 M. Coumarins inhibited IgE-mediated histamine release from RBL-2H3 cells as well as that of -hexosaminidase release (data not shown). Coumarin derivatives occur in various spice plants, and have been reported to have antitumoral, 15) fungicidal 16) and anti-inflammatory 17) activities. Although Ryu et al 18) have reported that cnidicin, a coumarin derivative, inhibited mast cell degranulation, degranulation inhibiting activity of 7-methoxycoumarin has not previously been reported.…”

Section: Resultsmentioning

confidence: 99%