Two years CD4 count follow-up of rural patients on antiretroviral therapy: A study in government hospital

Dravid, Mrudula N; Khadse, Ravindra; Kulkarni, Shubhangi D; Adchitre, Hitesh Ramesh

doi:10.4103/0253-7184.81261

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Post ART of 12 months patients were increased to 241 (89.59%) and 1 (0.37%) patient was static. Still there was decrease in CD4 counts in 27 (10.04%) patients so our study is similar to Ormaasan et al 13 and Dravid N et al 14 who had also reported poor CD4 cell recovery or no increase in CD4 count in a few patients Highleyman et al 15 had also reported poor CD4 cell recovery or no increase in CD4 count in a few patients on ART in their studies. So we have to separately evaluate the patients who showed rise and those who showed fall in CD4 count after ART to get the true picture.…”

Section: Resultssupporting

confidence: 87%

The Role of CD4 Count Pattern in HIV Seropositive Patients in Western Part of India

Chauhan

Sharma

Mishra

2022

Int J Health Sci Res

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Introduction: Human Immunodeficiency Virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) is the most dreadful disease & a major global health issue affecting mankind.CD4 cell count is one of most important investigations for evaluation of HIV infected patient. Our aim was to assess the CD4 count pattern in seropositive patients. Material &Methods: A study was conducted on 300 seropositive patients attending ICTC in Department of Microbiology at the tertiary care hospital, fulfilling inclusion and exclusion criteria, all above the age of 15 years, were studied for a period of 20months.In this study the CD4 counts estimated at the time of baseline (Pre ART), after 6 months and 12 months of (Post ART). Results: Mean of CD4 count on baseline (Pre ART) was 318.56±230.01. It improved to the 426.16±239.57 cells/mm3 after 6th months and 524.40±246.84 cells/mm3 after 12th months of ART. Mean CD4 counts in males was 298.56 ±220.92 and in females was 346.60 ±240.38 at baseline (Pre ART). Females showed significant improvement than males. Post ART after 6 months there were increase in number of patients from 89 to 149(55.39%) in >350 CD4 cells range, this is further increase to 205 (76.21%) patients after 12 months. Number of patients with an increasing trend of CD4 counts were seen in 224 (83.27%)patients at 6 months and 241 (89.59%) patients at 12th months, whereas 45 (16.73%) patients had a decreased trend in CD4 counts at post 6thmonths and 27 (10.04%) patients at 12th months of ART. Conclusion: The CD4 count is the hallmark surrogate marker for assessing prognosis in HIV infected patients. The programme needs to ensure that maximum number of patients are tested for HIV and linked to the ART centres. Key words: Antiretroviral therapy, CD4 count, HIV, HIV prognosis.

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Section: Resultssupporting

confidence: 87%

The Role of CD4 Count Pattern in HIV Seropositive Patients in Western Part of India

Chauhan

Sharma

Mishra

2022

Int J Health Sci Res

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“…ARV therapy can control virus replication and improve immune response by increasing the number of CD4 cell counts. Research showed that ARV therapy would increase CD4 cell counts of patients with HIV-AIDS (Dravid et al, 2011;Walker & Mcmichael, 2012).…”

Section: Introductionmentioning

confidence: 99%

Nutritional status and other predictors of immune response recovery among HIV-AIDS patients receiving antiretroviral therapy in Dr. Sardjito Hospital, Yogyakarta, Indonesia: a retrospective cohort study

Asturiningtyas¹,

Subronto²,

Kusmayanti³

2020

Mal J Nutr

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Introduction: Nutritional status and immune response of Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome (HIV-AIDS) patients are closely connected. There are limited studies assessing the influence of Body Mass Index (BMI) on immune response recovery among HIV patients in Indonesia. This study aimed to identify the BMI and other predictors of immune response recovery among HIV-AIDS patients following two years of Antiretroviral (ARV) therapy. Methods: This research was a retrospective cohort study among HIV-AIDS patients who started ARV therapy from January 2014 to December 2016 at Dr. Sardjito Hospital, Yogyakarta. Data were collected from ARV registry and medical reports. Data were analysed using linear regression. Results: A total of 255 patients were included in the study, with a median BMI of 20.07 kg/m2. Results showed that BMI was not significantly correlated with immune response recovery at the 6th, 12th, 18th, and 24th months of ARV therapy (p>0.05). But, the increase in cluster of differentiation 4 (CD4) cell count was higher in overweight and pre-obese patients than underweight patients, especially in the 18th and 24th months of therapy. Factors related to immune response recovery were the regularity of treatment at the 12th, 18th, and 24th months of ARV therapy, and the use of Tenofovir at 18th-month therapy (p<0.05). Conclusion: Immune response recovery was higher in overweight and pre-obese patients. Using Tenofovir type ARV and doing treatment regularly can increase CD4 cell counts. Underweight patients need to enhance their nutritional status to improve their immune response during ARV therapy.

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Two years CD4 count follow-up of rural patients on antiretroviral therapy: A study in government hospital

Cited by 2 publications

References 4 publications

The Role of CD4 Count Pattern in HIV Seropositive Patients in Western Part of India

The Role of CD4 Count Pattern in HIV Seropositive Patients in Western Part of India

Nutritional status and other predictors of immune response recovery among HIV-AIDS patients receiving antiretroviral therapy in Dr. Sardjito Hospital, Yogyakarta, Indonesia: a retrospective cohort study

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