Two new alkaloids from marine sponge<i>Callyspongia</i>sp.

Yang, Bin; Tao, Huaming; Zhou, Xuefeng; Lin, Xiuping; Liu, Yonghong

doi:10.1080/14786419.2012.734819

Cited by 16 publications

(14 citation statements)

References 14 publications

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“…(Hainan Is., China). 630 Synthesis conrmed the structures of amphimedosides A-C (Amphimedon sp.). 672,673 Pyrinodemins G-I 646-648 are bis-3alkylpyridinium alkaloids from Amphimedon sp.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2015

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“…1 We have already reported a great number of chemical constituents from marine sponge. [2][3][4][5] Sponge-derived fungi represent a competitive source for new and biologically active natural products. In the past few years, many novel bioactive compounds from the genus Stachybotry displayed antihyperlipidemic, 6 plasminogen-modulating activity, 7 antiinfluenza virus agents.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

Qin

Lin

et al. 2014

J Antibiot

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A new (2) and four known (1, 8-10) sesquiterpenoids, two new (3 and 4) and eight known (5-7, 11-15) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1-15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5, 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3, 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4, 5 and 11 showed activities against intestinal virus EV71.

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“…Compound 16a has also been identified in Callyspongia pseudoreticulata (MeOH extract) [34,35]. In addition, callyspongendiol (17) was isolated from Callyspongia siphonella (CH 2 Cl 2 /MeOH 1:1 extract) [8,36], and Tetrahydrosiphonodiol (18) from Callyspongia lindgreni (EtOH extract) [32]. Polyacetylene Diols 13-18 are open chain unsaturated hydrocarbons (Figure 1 and Table S1) that have their structures elucidated by 1 H and 13 C NMR.…”

Section: Terpenoids and Steroidsmentioning

confidence: 99%

“…Some alkaloids were obtained from EtOH 95% extract of Callyspongia sp. : callyimine A (111) [18], callylactam A (112) [18], clathryimine B (113 93) and 24S-24-methylcholesterol (94), 5α-cholestanone (95), callysterol (96 and 97) or ergosta-5,11-dien-3β-ol (97), cholestenone (98), Stigmasta-4,22-dien-3,6-dione (99), stigmasterone (100), gelliusterol E (101), β-sitosterol (102), siphonocholin (103), and ergosta-5,24(28)-dien-3β-ol (104). The obtainment of these metabolites is associated with the following extracts: 89-94 to MeOH extract from Callyspongia fibrosa [23]; 95, 96 [7], 98-100 [7], and 103 [63,64] to EtOH extract from Callyspongia siphonella; 97 [19] and 104 [8] to MeOH/CH 2 Cl 2 1:1 extract from Callyspongia siphonella and, 101, and 102 to MeOH/CH 2 Cl 2 1:1 extract from Callyspongia implexa [28].…”

Section: Alkaloidsmentioning

confidence: 99%

“…As confirmed by biological studies, Callyspongia's species are very rich sources of bioactive compounds. Several classes of primary and secondary metabolites have been associated with the genus, such as fatty acids [17], alkaloids [18], steroids [19], nucleosides [20], peptides [4], polyacetylenes [21], and terpenoids [11]. Furthermore, molecules isolated from these species are found to present relevant biological activities, including antibacterial [7], antituberculosis [22], anti-inflammatory [19], antimalarial [23], and cytotoxic [7,12,24].…”

Section: Introductionmentioning

confidence: 99%

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Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

et al. 2021

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The genus Callyspongia (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of Callyspongia are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic, and the East Pacific Oceans. The reason for the interest in the genus Callyspongia is related to its potential production of bioactive compounds. In this review, we group the chemical information about the metabolites isolated from the genus Callyspongia, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus Callyspongia (15 species and Callyspongia sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipeptides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant.

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Two new alkaloids from marine spongeCallyspongiasp.

Abstract: Two new alkaloids, callylactam A (1) and callyimine A (4), along with three known ones (2, 3 and 5), were isolated from the marine sponge Callyspongia sp. The structures were determined on the basis of NMR and MS analysis.

Cited by 16 publications

References 14 publications

Marine natural products

Marine natural products

Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

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