Marine natural products

Blunt, John W.; Copp, Brent R.; Keyzers, Robert A.; Munro, Murray H. G.; Prinsep, Michèle R.

doi:10.1039/c4np00144c

Cited by 609 publications

(509 citation statements)

References 931 publications

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“…1,2) During our studies on the search for bioactive secondary metabolites from various natural resources such as plants 3) and myxomycetes 4) and other microorganisms, we have developed a particular interest in a screening program for new natural products from actinomycetes 5) isolated from soil samples collected in various locations in Japan, mainly from Chiba Prefecture, using in-house biological assays targeting cancer-related pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) 6) and Wnt 7) signaling. TRAIL is a member of the tumor necrosis factor (TNF) family of apoptosis-triggering proteins.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

2016

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Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new natural products mainly possessing heterocyclic and aromatic ring structures with biological effects on cancerrelated cellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.

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Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

2016

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“…1) Sponges of the genus Dysidea are a rich source of bioactive meroterpenoids, the majority of which are sesquiterpene quinones/quinols.…”

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confidence: 99%

Antibacterial Meroterpenoids from the South China Sea Sponge <i>Dysidea</i> sp.

Zhang

Huang

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Key words meroterpenoid; marine sponge; antibacterial activity; DysideaMarine organisms such as sponges represent a largely unexploited source of a wide variety of natural meroterpenoids.1) Sponges of the genus Dysidea are a rich source of bioactive meroterpenoids, the majority of which are sesquiterpene quinones/quinols.2) This class of compounds frequently consist of sesquiterpene moieties linked to quinones, quinols, or structural analogues.3) The sesquiterpene unit is of biosynthetic interest, as it usually features a drimane-or a 4,9-friedodrimane-type skeleton comprising a trans-or a less common cis-fused ring junction.3) These compounds have attracted much interest due to their structural diversity and varied biological activities, including anti-human immunodeficiency virus (HIV), 4) antibacterial, 5) antifungal, 6) antioxidative, 7) antitumor, 8) anti-inflammatory, 9) inhibition against protein tyrosine kinase (PTK) and protein tyrosine phosphatase 1B (PTP1B), 10,11) and activation of hypoxia-inducible factor-1 (HIF-1) activities. 12)During our search for bioactive metabolites from tropical sponges, we encountered a purple-colored encrusting Dysidea sp. off the south China sea. The crude extract of this sponge showed significant antibacterial activity against Staphylococcus aureus (25923) with the minimum inhibitory concentration (MIC) value of 25 µg/mL. Chemical investigation of bioactive extracts of this sponge led to the isolation of three new sesquiterpene phenols (1−3) and one new sesquiterpene aminoquinone (4), together with four known sesquiterpene derivatives (5−8). Herein, we report the details of the purification and structure elucidation of these compounds, as well as the evaluation of antibacterial activity (Fig. 1). Results and Discussion

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“…Some sponges may produce their own biologically active natural products against predators, competitors, or foulers, and others may benefit from the defensive properties of the metabolites produced by their microbes (Pawlik et al 1995, Newbold et al 1999, Amsler et al 2000. Though chemical defences have been well studied in the phylum Porifera (Müller et al 2004, Sipkema et al 2005, Proksch et al 2010, and it has been the preferred phylum of the marine natural product community over the last 50 years (Blunt et al 2015), the origin of many compounds still remains controversial (König et al 2006, Wang 2006, Hentschel et al 2012.…”

Section: Sponge Chemical Ecology and Microbial Ecologymentioning

confidence: 99%

Publication impact in sponge chemical and microbial ecology

Sacristán-Soriano

Becerro²

2016

Sci. Mar.

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Summary:It is well known that sponges constitute one of the most prevalent groups in marine benthic communities based on their challenging structural organization, abundance and diversity, and their functional roles in natural communities. The evolutionary success of this group may be explained by the close interaction between sponges and microbes, which dates back to the Precambrian era. This particular symbiosis has become a key factor within sponge research and is an emerging topic of two scientific disciplines: chemical and microbial ecology. This mini-review evaluates the influence of these two disciplines on the general scientific community using a series of bibliometric indicators to ensure objectivity. Our analyses showed that, although sponge chemical ecology has a greater overall impact on the scientific community, both disciplines are cited equally and more frequently than expected. Both research areas show a great impact on applied sciences, but the ecological perspectives of sponge chemistry and microbiology may fall outside the interests of a broader ecological audience. Moreover, we highlight some research topics (e.g. effects of environmental stress) that may require further attention. Hence, sponge chemical and microbial ecology have the opportunity to contribute to broader ecological issues in topics that make sponges particularly important, such as symbiosis.Keywords: Porifera research; natural products; microbiology; symbiosis; h-index; bibliometric indicators. Impacto de las publicaciones en ecología química y microbiana de esponjasResumen: Las esponjas constituyen uno de los grupos predominantes en las comunidades bentónicas marinas gracias a su potencial organización estructural, abundancia, diversidad y a las funciones que desempeñan en las comunidades naturales. El éxito evolutivo de este grupo yace en la estrecha interacción con microorganismos que data del Precámbrico. Esta particular simbiosis se ha convertido en un factor clave en la investigación sobre esponjas y está emergiendo en dos campos como el de la ecología química y microbiana. Esta mini-revisión evalúa la influencia de estas dos disciplinas en la comunidad científica utilizando una serie de indicadores bibliométricos para asegurar la objetividad. Nuestro análisis muestra que aunque la ecología química presenta un mayor impacto global, ambos campos son citados de manera similar y con una frecuencia superior a la esperada. Ambas áreas presentan un gran impacto en ciencias aplicadas, pero las perspectivas ecológicas de las dos disciplinas científicas deben quedar fuera de los intereses generales de la comunidad de ecólogos. Además, señalamos algunas áreas (e.g. efectos del estrés ambiental) que necesitarían mayor atención. Por tanto, la ecología química y microbiana de esponjas tienen la oportunidad de contribuir sobre cuestiones de ecología general con temas que las hace particularmente relevantes, como es la simbiosis.Palabras clave: investigación en Porifera; productos naturales; microbiología; simbiosis; índice h; indicad...

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Marine natural products

Cited by 609 publications

References 931 publications

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Antibacterial Meroterpenoids from the South China Sea Sponge <i>Dysidea</i> sp.

Publication impact in sponge chemical and microbial ecology

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