Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

Qin, Chun; Lin, Xiuping; Lu, Xin; Wan, Junting; Zhou, Xuefeng; Liao, Shengrong; Tu, Zhengchao; Xu, Shi‐Hai; Liu, Yonghong

doi:10.1038/ja.2014.97

Cited by 50 publications

(35 citation statements)

References 23 publications

(17 reference statements)

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“…Examples of such fungal chlorinated xanthones are 4-chloropinselin from Monilinia fructicola and Bipolaris sorokiniana [40,42], chloroisosulochrin dehydrate from P. theae [49], 3,6,8-trihydroxy-5-chlorin-1-methylxanthone from Stachybotrys sp. [53], 4-chlorofischexanthone from Alternaria sp. [54].…”

Section: Discussionmentioning

confidence: 99%

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

et al. 2020

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The fungus, Alternaria sonchi is considered to be a potential agent for the biocontrol of perennial sowthistle (Sonchus arvensis). A new chlorinated xanthone, methyl 8-hydroxy-3-methyl-4-chloro-9-oxo-9H-xanthene-1-carboxylate (1) and a new benzophenone derivative, 5-chloromoniliphenone (2), were isolated together with eleven structurally related compounds (3–13) from the solid culture of the fungus, which is used for the production of bioherbicidal inoculum of A. sonchi. Their structures were determined by spectroscopic (mostly by NMR and MS) methods. Alternethanoxins A and B, which were reported in A. sonchi earlier, were re-identified as moniliphenone and pinselin, respectively. The isolated compounds were tested for phytotoxic, antimicrobial, insecticidal, cytotoxic and esterase-inhibition activities. They did not demonstrate high phytotoxicity (lesions up to 2.5 mm in diameter/length at a concentration of 2 mg/mL) when tested on leaf disks/segments of perennial sowthistle (Sonchus arvensis) and couch grass (Elytrigia repens). They did not possess acute toxicity to Paramecium caudatum, and showed moderate to low cytotoxicity (IC50 > 25 µg/mL) for U937 and K562 tumor cell lines. However, chloromonilicin and methyl 3,8-dihydroxy-6-methyl-4-chloro-9-oxo-9H-xanthene-1-carboxylate (4) were shown to have antimicrobial properties with MIC 0.5–5 µg/disc. Compound 4 and chloromonilinic acid B were found to have contact insecticidal activity to wheat aphid (Schizaphis graminum) at 1 mg/mL. Compounds 2 and methyl 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate displayed selective carboxylesterase inhibition activity at concentration of 100 µg/mL. Therefore, the waste solid substrate for production of A. sonchi spores can be re-utilized for the isolation of a number of valuable natural products.

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Section: Discussionmentioning

confidence: 99%

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

et al. 2020

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“…HH1 ZDDS1F1-2 has yielded several sesquiterpenoids and xanthones, totaling 15 compounds. In addition to the two new xanthones, stachybogrisephenones A ( 449 ) and B ( 450 ), the three known compounds grisephenone A ( 451 ), 452 , and 453 are cytotoxic towards U937, HeLa, and K562 cell lines ( Figure 84 ) [ 163 ]. Grisephenone A ( 451 ) has IC 50 22.5 and 14.6 µM towards U937 and HeLa cells, respectively.…”

Section: Antitumor Compoundsmentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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“…HH1 ZDDS1F1-2, have been evaluated against in vitro replication of EV-71. The so-called compounds showed inhibitory activities against in vitro replication of EV71 with IC 50 values of 30.1, 50.0 and 40.3 μM [ 34 ]. The efficiency of these cytotoxic compounds identified them as potential candidates for further studies towards drug discovery for EV-71 and other related viruses such as Coxsackie virus [ 35 ].…”

Section: Marine Fungi and Their Antiviral Activitymentioning

confidence: 99%

Potential Antiviral Agents from Marine Fungi: An Overview

et al. 2015

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Biodiversity of the marine world is only partially subjected to detailed scientific scrutiny in comparison to terrestrial life. Life in the marine world depends heavily on marine fungi scavenging the oceans of lifeless plants and animals and entering them into the nutrient cycle by. Approximately 150 to 200 new compounds, including alkaloids, sesquiterpenes, polyketides, and aromatic compounds, are identified from marine fungi annually. In recent years, numerous investigations demonstrated the tremendous potential of marine fungi as a promising source to develop new antivirals against different important viruses, including herpes simplex viruses, the human immunodeficiency virus, and the influenza virus. Various genera of marine fungi such as Aspergillus, Penicillium, Cladosporium, and Fusarium were subjected to compound isolation and antiviral studies, which led to an illustration of the strong antiviral activity of a variety of marine fungi-derived compounds. The present review strives to summarize all available knowledge on active compounds isolated from marine fungi with antiviral activity.

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Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

Cited by 50 publications

References 23 publications

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

Biological Activity of Recently Discovered Halogenated Marine Natural Products

Potential Antiviral Agents from Marine Fungi: An Overview

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