Two flavans from Brosimum acutifolium

Torres, Sérgio Luiz; Monteiro, João Carlos M.; Arruda, Mara Silvia Pinheiro; Müller, Adolfo Henrique; Arruda, Alberto C.

doi:10.1016/s0031-9422(96)00447-5

Cited by 20 publications

(14 citation statements)

References 3 publications

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“…Thus, the structure of brosimacutin J (1) was determined to be (2S)-7,8-furano-4¢-hydroxyflavan. Tables 1 and 2) were similar to those of 4'-hydroxy-7,8-(3¢¢-hydroxy-2¢¢,2¢¢-dimethylpyran)flavan, previously isolated from this plant [7]. The HMQC and HMBC correlations (Fig.…”

Section: Resultssupporting

confidence: 80%

Brosimacutins J - M, Four New Flavonoids fromBrosimum acutifoliumand their Cytotoxic Activity

Takashima¹,

Komiyama²,

Ishiyama³

et al. 2005

Planta med

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Four new flavonoids, brosimacutins J-M (1 - 4), were isolated from the bark of Brosimum acutifolium Huber together with a known flavan, brosimine A (5). The structures of compounds 1-4 were elucidated by spectroscopic means. 27 constituents of this plant including compounds 1-5 were evaluated for their cytotoxic activity against murine leukemia P388 cells. Although no compounds tested had any reversal effect on vincristine resistance, brocimacutins J-M (1-4) were cytotoxic to vincristine-resistant P388 cells (IC50 4.4 - 19 microg/mL).

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Section: Resultssupporting

confidence: 80%

Brosimacutins J - M, Four New Flavonoids fromBrosimum acutifoliumand their Cytotoxic Activity

Takashima¹,

Komiyama²,

Ishiyama³

et al. 2005

Planta med

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“…There is a recent report of the isolation of two flavans from the dichloromethane extract of the bark of this plant. 4 …”

Section: Introductionmentioning

confidence: 99%

Structure determination by1H and13C NMR of a new flavan isolated fromBrosimum acutifolium: 4?,7-dihydroxy-8-prenylflavan

Teixeira

Alcântara²,

Piló‐Veloso

2000

Magn. Reson. Chem.

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“…biologicamente ativas (Pozetti 1969;Elisabetsky & Castilhos 1990;Vilegas et al 1993;Shirota et al 1997;Torres et al 1997;Alcântara et al 2000;Takashima & Ohsaki 2001;Takashima et al 2002).…”

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Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

2007

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RESUMO -(Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)). Brosimum gaudichaudii, conhecida como mamacadela, é espécie comum nos cerrados, com grande valor na medicina popular e na indústria de medicamentos. A casca da raiz e do caule é empregada no tratamento do vitiligo, sendo o bergapteno e psoraleno, duas furanocumarinas, responsáveis pela ação farmacológica. Neste trabalho são apresentadas a caracterização morfoanatômica e a histoquímica de órgãos vegetativos de B. gaudichaudii, com informações sobre o embrião e o desenvolvimento pós-seminal. Amostras foram processadas segundo técnicas usuais em anatomia e ultra-estrutura vegetal. O embrião é do tipo total e invaginado, a plântula cripto-hipogéia e o sistema radicular do tirodendro é composto por raiz primária pouco desenvolvida em relação às raízes laterais. Plantas adultas apresentam raízes gemíferas longas, plagiotrópicas originando ramos caulinares aéreos; tais raízes possuem periderme com súber desenvolvido e floema secundário abundante em relação ao xilema, sendo facilmente destacados quando manipulados. O caule jovem e a folha apresentam epiderme unisseriada, grande densidade de tricomas tectores unicelulares e tricomas glandulares. Laticíferos não-articulados ramificados ocorrem em todos os órgãos, podendo invadir os elementos de vaso. Idioblastos fenólicos ocorrem em abundância em todos tecidos e órgãos analisados. O valor das características anatômicas observadas no controle de qualidade da droga é discutido. Palavras-chave:Brosimum gaudichaudii, idioblastos fenólicos, laticíferos, mamacadela, raízes gemíferas ABSTRACT -(Morphoanatomy and histochemistry of the Brosimum gaudichaudii Trécul (Moraceae)). Brosimum gaudichaudii known as "mamacadela" is a common cerrado species with a great importance on medicine folk and in the pharmaceutical industry. The bark of the root and stem is used on the treatment of "vitiligo" being the bergapten and psoralen two furocoumarins responsible for pharmacological activity. This work presents the morphoanatomical and histochemical characterization of the vegetative organs of B. gaudichaudii, with information about its embryo and post-seminal development. Samples were processed by usual techniques of plant anatomy and ultra-structure. The embryo is of the total type and invaginate, the seedling is crypto-hypogeal and the tirodentro's radicular system is composed by primary root that is not always well developed when compared to other roots that probably are derived of the hypocotyl which have greater size. The adult plants present long shoot bud-forming roots and plagiotropics origining with air branch. These roots present a periderm with developed phellem and secondary phloem more developed than xylem, being both easily eminent when manipulated. The stem and the leaf show unisseriate epidermis with a high density of unicellular non-glandular trichomes and glandular trichomes. The laticiferous are branched and non-articulate, occurring at all organs mostly frequently inside of the vessel elem...

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Two flavans from Brosimum acutifolium

Cited by 20 publications

References 3 publications

Brosimacutins J - M, Four New Flavonoids fromBrosimum acutifoliumand their Cytotoxic Activity

Brosimacutins J - M, Four New Flavonoids fromBrosimum acutifoliumand their Cytotoxic Activity

Structure determination by1H and13C NMR of a new flavan isolated fromBrosimum acutifolium: 4?,7-dihydroxy-8-prenylflavan

Morfoanatomia e histoquímica de Brosimum gaudichaudii Trécul (Moraceae)

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