Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane

Fang, Jinghan; Liu, Runheng; Chen, Shoucheng; Liu, Quan; Cai, Huaxiong; Lin, Yixiong; Chen, Zetao; Chen, Zhuofan

doi:10.1016/j.actbio.2020.03.038

Cited by 18 publications

(17 citation statements)

References 67 publications

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“…As a foreign biomaterial, porcine-derived CMs will inevitably trigger hostmembrane immune response after implantation, which involves the activation of phagocytic cells. The cell-mediated degradation may be involved in the CM degradation process (Fang et al, 2020), and this overinflammatory state produces an adverse microenvironment for tissue repair. Nevertheless, a cocktail of growth factors with A-PRF, such as transforming growth factor β (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF), can actively trigger and orchestrate the tissue repair processes (Marx, 2004;Aminabadi, 2008;Peerbooms et al, 2010;Soloviev et al, 2014;Herath et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model

Xin

Yuan

et al. 2020

Front. Bioeng. Biotechnol.

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BackgroundSchneiderian membrane (SM) perforation is a major complication of maxillary sinus elevation with simultaneous bone grafting, yet under this scenario there is no standard biomaterial that maximizes favorable tissue healing and osteogenic effects.PurposeTo compare the effect of advanced platelet-rich fibrin (A-PRF) and collagen membrane (CM) on a perforated SM with simultaneous bone grafting in a maxillary sinus elevation model.Materials and MethodsAfter perforation of the SM was established, 24 animals were randomly divided into two groups: (i) group CM: CM and deproteinized bovine bone mineral (DBBM) (n = 12), (ii) group A-PRF: A-PRF and DBBM (n = 12). Radiographic and histological evaluations were performed at 1 and 4 weeks post-operation.ResultsAt 1 week, an intact SM was found in group A-PRF. At each time point, the number of inflammatory cells at the perforated site was higher in group CM, and the area of new osteoid formation was significantly greater in group A-PRF (p < 0.0001). At 4 weeks, the osteogenic pattern was shown as from the periphery to the center of the sinus cavity in group A-PRF.ConclusionThe higher elasticity, matching degradability, and plentiful growth factors of A-PRF resulted in a fully repaired SM, which later ensured the two osteogenic sources from the SM to generate significant new bone formation. Thus, A-PRF can be considered to be a useful bioactive tissue-healing biomaterial for SM perforation with simultaneous bone grafting.

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Section: Discussionmentioning

confidence: 99%

Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model

Xin

Yuan

et al. 2020

Front. Bioeng. Biotechnol.

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“…While commercial resorbable barrier membranes have been used for single-step surgical regeneration procedures in clinical, they still have limitations such as high cost, poor mechanical property, improper biodegradation, and unpredictable clinical outcomes especially in horizontal periodontal bone defects [ 5 ]. Therefore, the development of artificial biodegradable membranes with low cost, unique structures, proper physicochemical properties and biological ability to achieve more satisfactory tissue regeneration attract increasing attention recently [ [6] , [7] , [8] ].…”

Section: Introductionmentioning

confidence: 99%

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering

Ren

Zhou

Zheng

et al. 2022

Bioactive Materials

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Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration, in which new attempts come out along with the development of nanomaterials. Herein, the effect of cerium oxide nanoparticles (CeO 2 NPs) on the cell behavior and function of human periodontal ligament stem cells (hPDLSCs) was investigated. Results of CCK-8 and cell cycle tests demonstrated that CeO 2 NPs not only had good biocompatibility, but also promoted cell proliferation. Furthermore, the levels of alkaline phosphatase activity, mineralized nodule formation and expressions of osteogenic genes and proteins demonstrated CeO 2 NPs could promote osteogenesis differentiation of hPDLSCs. Then we chose electrospinning to fabricate fibrous membranes containing CeO 2 NPs. We showed that the composite membranes improved mechanical properties as well as realized release of CeO 2 NPs. We then applied the composite membranes to in vivo study in rat cranial defect models. Micro-CT and histopathological evaluations revealed that nanofibrous membranes with CeO 2 NPs further accelerated new bone formation. Those exciting results demonstrated that CeO 2 NPs and porous membrane contributed to osteogenic ability, and CeO 2 NPs contained electrospun membrane may be a promising candidate material for periodontal bone regeneration.

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“…The main raw materials of non‐cross‐linked collagen membranes used in GBR are type I and III collagens, mainly derived from pigs, cows, and some other mammalian species 27 . Host immunologic response or even foreign body reaction (FBR) to the non‐cross‐linked collagen membranes might affect the bone regeneration procedure in GBR 28 . The extent of FBR to the membrane in the context of different origin and biophysical structure could be only mononuclear cells inducing, or include multinucleated giant cells (MNGCs) formation resulting in early collagen membrane disintegration 29 .…”

Section: Introductionmentioning

confidence: 99%

A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes

et al. 2022

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The porcine-derived non-cross-linked collagen membrane Bio-gide ® (BG) and the bovine-derived non-cross-linked collagen membrane Heal-all ® (HA) were compared to better understand their in vitro biophysical characteristics and in vivo degradation patterns as a reference for clinical applications. It was showed that the porosity, specific surface area, pore volume and pore diameter of BG were larger than those of HA (64.5 ± 5.2% vs. 48.6 ± 6.1%; 18.6 ± 2.8 m 2 /g vs. 2.3 ± 0.6 m 2 /g; 0.114 ± 0.002 cm 3 /g vs. 0.003 ± 0.001 cm 3 /g; 24.4 ± 3.5 nm vs. 7.3 ± 1.7 nm, respectively); the average swelling ratio of BG was higher than that of HA (412.6 ± 41.2% vs. 270.0 ± 2.7%); the tensile strength of both dry and wet HA was higher than those of BG (18.26 ± 3.27 MPa vs. 4.02 ± 1.35 MPa; 2.24 ± 0.21 MPa vs. 0.16 ± 0.02 MPa, respectively); 73% of HA remained after 72 h in collagenase solution, whereas only 8.2% of BG remained. A subcutaneous rat implantation model revealed that, at 3, 7, 14, 28, and 56 days postmembrane implantation, there were more total inflammatory cells, especially more M1 and M2 polarized macrophages and higher M2/M1 ratio in BG than in HA; in addition, the fibrous capsule around BG was also thicker than that around HA. Moreover, concentrations of dozens of cytokines including interleukin-2(IL-2), IL-7, IL-10 and so forth. in BG were higher than those in HA. It is suggested that BG and HA might be suitable for different clinical applications according to their different characteristics.

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Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane

Cited by 18 publications

References 67 publications

Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model

Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering

A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes

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