Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemotherapy for primary and advanced osteosarcomas

Zhang, Yi; Cai, Lulu; Li, Di; Lao, Yeh‐Hsing; Liu, Dingzhuo; Li, Mingqiang; Ding, Jianxun; Chen, Xuesi

doi:10.1007/s12274-018-2066-0

Cited by 103 publications

(59 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most anticancer effective nanoformulations in monolayer and spheroids are those with FA (HAP-Pip9.3-GA-FA 671 and HAP-P-Pip9.3-GA-FA). Our findings are in the line with using of nanomedicine application for cancer targeting strategies and controlled release of anticancer drugs by various nanostructures [82][83][84]. shrinkage, and defragmentation of spheroids.…”

Section: Discussionsupporting

confidence: 86%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

View full text Add to dashboard Cite

Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

show abstract

Section: Discussionsupporting

confidence: 86%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The hydrophobic antitumor drug of HCPT was encapsulated into CS through facile diffusion (Scheme 1). Electrostatic interaction is the main reason for drug encapsulation [20]. The preparation method was simple and straightforward.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Guo

Qiu

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.

show abstract

“…Compared with conventional preparations, the metabolic time of nano-transporter drugs in the blood circulation may be prolonged. By regulating pH value (Gao et al, 2018;Yi et al, 2018), temperature (Wei L. et al, 2017), light , ultrasound or biological enzyme (Zhang et al, 2019), the rate of those targeted nano-transporter drugs can be controlled to function longer.…”

Section: Targeting Strategy Of the Nddssmentioning

confidence: 99%

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Deng

Zhang

Shen

et al. 2020

Front. Bioeng. Biotechnol.

162

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far from satisfactory due to poor water solubility, low biological efficacy, non-targeting, and drug resistance. Nano-drug delivery systems (NDDSs) provide a new drug delivery method for the treatment of CVDs with the development of nanotechnology, demonstrating great advantages in solving the above problems. Nevertheless, there are some problems about NDDSs need to be addressed, such as cytotoxicity. In this review, the types and targeting strategies of NDDSs were summarized, and the new research progress in the diagnosis and therapy of CVDs in recent years was reviewed. Future prospective for nano-carriers in drug delivery for CVDs includes gene therapy, in order to provide more ideas for the improvement of cardiovascular drugs. In addition, its safety was also discussed in the review.

show abstract

Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemotherapy for primary and advanced osteosarcomas

Cited by 103 publications

References 69 publications

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Contact Info

Product

Resources

About