2019
DOI: 10.1155/2019/1914976
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Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Abstract: Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading cont… Show more

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Cited by 10 publications
(6 citation statements)
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“…Furthermore, the cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The research indicated that the positively charged CS-based nanogels could be used as a drug delivery agent [111].…”
Section: Polymer Hydrogels and Nanogelsmentioning
confidence: 99%
“…Furthermore, the cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The research indicated that the positively charged CS-based nanogels could be used as a drug delivery agent [111].…”
Section: Polymer Hydrogels and Nanogelsmentioning
confidence: 99%
“…Therapeutically, chitosan has been employed as a polymer-based nano-drug platform(s) in numerous biomedical applications for the delivery of a variety of drug types for the treatment of cancers [ 15 , 16 ]. Chitosan has a slow circulatory pattern and a low immunological clearance rate [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“… 81 Guo et al formulated a chitosan-based nanogel to inhibit the proliferation of breast cancer cell lines, where the model drug of 10-hydroxycamptothecin (HCPT) was entrapped into core by facile diffusion to form chitosan/10-hydroxycamptothecin (CS/HCPT). 82 From the prepared formulation the outcome was evaluated by assessing particle size, drug loading content and drug loading efficiency. Further cytotoxicity, apoptosis of CS/HCPT, was also investigated in vitro.…”
Section: Resultsmentioning
confidence: 99%
“…Further cytotoxicity, apoptosis of CS/HCPT, was also investigated in vitro. 82 Nascimento et al synthesized a delivery system in which non-targeted delivery was done of chitosan, polyethylene glycol and siRNA. 83 The outcome showed that there was an inhibition in tumor tissues in animal model and faster elimination.…”
Section: Resultsmentioning
confidence: 99%