Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis

Chen, Tengfei; Liu, Yali; Li, Chang; Xu, Chun; Ding, Cheng

doi:10.1016/j.ctarc.2021.100412

Cited by 49 publications

(54 citation statements)

References 41 publications

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“…Breast cancer cells deliver lncRNA SNHG16 through exosomes to induce γδ1 Treg cells to upregulate the expression of CD74 ( 104 ). The metastasis of nonsmall cell lung cancer can be promoted when nonsmall cell lung cancer cells transfer exosomal circFARSA to mediate M2 macrophage polarization through the PTEN/PI3K/AKT axis ( 105 ). Overall, exosomal ncRNAs participate in the suppression of the immune microenvironment in a variety of tumors, thereby promoting tumor progression.…”

Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

et al. 2021

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Bladder cancer (BCa) is a common heterogeneous urinary system tumor with high malignancy and limited advancement in treatment. Limited understanding of BCa has not contributed to any significant progress in diagnosis or treatment, exploring the mechanisms underlying BCa has become an urgent research focus. Exosomes, a type of extracellular vesicle (EV), have drawn substantial interest for their important roles in mediating intracellular communication. Exosomes shuttle numerous bioactive molecules, and noncoding RNAs (ncRNAs) are among the most numerous. ncRNAs including microRNA, long noncoding RNA, and circular RNA are sorted and packaged into exosomes selectively and transferred into recipient cells to regulate their function. Exosomal ncRNAs are associated with hallmarks of BCa, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), cell cycle arrest, lymphangiogenesis, and chemotherapy resistance. Exosomal ncRNAs can also be detected in urine and serum, making them encouraging biomarkers for BCa diagnosis and prognosis. More importantly, exosomes exhibit excellent biocompatibility and potential for diversified applications. The delivery of bioactive substances and drugs into specific cells has become a promising approach for precision therapy for BCa patients. In addition, cancer vaccines have also received increasing attention. In this review, we summarize the current research on the regulatory roles of exosomal ncRNAs in BCa tumorigenesis and progression, as well as their potential clinical value in accelerating the diagnosis and therapy of BCa.

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Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

et al. 2021

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“… 157 Besides, circRNA-002178 shuttled by exosomes can be transferred to CD8 + T cells thus promoting generation of programmed death-ligand 1 (PDL1)/programmed cell death protein 1 (PD1) in LUAD. 158 In addition, the expression levels of exosomal circ-0007761, circ-0047921, circ-0056285, circ-0008928, circRNA-102481, circ-MEMO1, circ-ARHGAP10, circ-PIP5K1A, and circ-FARSA are changed in NSCLC, 159 – 165 while that of exosomal circ-0000690, circ-0001346, circ-0001439, and circ-0001492 are significantly increased in LUAD, which have potential as promising diagnostic biomarkers. 166 …”

Section: The Roles Of Exosomal Ncrnas In Human Diseasesmentioning

confidence: 99%

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

et al. 2021

Sig Transduct Target Ther

199

127

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Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.

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“…For example, circFARSA is elevated in NSCLC cells and associated with the elevation of EMT and metastasis. Moreover, circFARSA derived from NSCLC cells induces tumor TAMs polarization to M2 phenotype by promoting PTEN ubiquitination and subsequent degradation, thereby activating the PI3K/AKT signaling pathway 53 .…”

Section: Functions Of Exosomal Circrnas In the Tmementioning

confidence: 99%

The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy

Li¹,

Zhang²,

Liu³

et al. 2022

Theranostics

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Exosomes are multifunctional regulators of intercellular communication by carrying various messages under both physiological and pathological status of cancer patients. Accumulating studies have identified the presence of circular RNAs (circRNAs) in exosomes with crucial regulatory roles in diverse pathophysiological processes. Exosomal circRNAs derived from donor cells can modulate crosstalk with recipient cells locally or remotely to enhance cancer development and propagation, and play crucial roles in the tumor microenvironment (TME), leading to significant enhancement of tumor immunity, metabolism, angiogenesis, drug resistance, epithelial mesenchymal transition (EMT), invasion and metastasis. In this review, we describe the advances of exosomal circRNAs and their roles in modulating cancer hallmarks, especially those in the TME. Moreover, clinical application potential of exosomal circRNAs in cancer diagnosis and therapy are highlighted, bridging the gap between basic knowledge and clinical practice.

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Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis

Cited by 49 publications

References 41 publications

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy

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