Tumor angiogenic factor and human skin tumors

Keloid heterograft in the hamster (Mesocricetus auratus) cheek pouch

“…14 A literature report refers the absence of vascular proliferation or vasedilation between the 3 rd and 7 th days after transplantation, and cites only the appearing of a sinuosity in the blood vases. 20 However, these data diverge from the ones obtained by the present study. The distinct sinuosity observed by these Authors, at the 3 rd or 4 th post-operative day, would be a specific vascular response to the transplantation, and would only occur to a distance of 5 mm around the graft.…”

“…17,18 In the literature, there are studies where the cheek pouch was used to transplant tissues of both benign diseases and malignant neoplasias in order to investigate physiopathology and treatments. 19,20 In terms of keloid, in spite of the growing trend existing among most of surgical specialties -besides the Plastic Surgery 9,21 -being also searching after achieving esthetical results, we have scarce literature which is not enough detailed about keloid in the hamster cheek pouch. It was only studied the change of the vascular pattern of this lesion, and simply as a single mention.…”

“…It was only studied the change of the vascular pattern of this lesion, and simply as a single mention. 20 The present study purpose is to investigate the integration of keloid heterologous graft into hamster cheek pouch sub-epithelium, as an experimental model.…”

Integração do enxerto heterólogo de pele humana no subepitélio da bolsa jugal do hamster (Mesocricetus auratus)

“…Esses resultados estão de acordo com aqueles encontrados por Lemon e col. (1952), (25) que descreveram um índice de complicações pós-operatórias, em enxertos na bolsa jugal do hamster, inferior a 5%, também sem terem observado as normas de assepsia. Outros autores, entretanto, adicionaram profilaticamente tetraciclina (16) ou acromicina (19) na água ingerida pelos hamsters, embora tenham realizados suas pesquisas com as bolsas exteriorizadas.…”

“…Na literatura também são citados trabalhos onde se utilizou a bolsa jugal ou da bochecha para enxertar tecidos de doenças benignas e neoplasias malignas cutâneas, a fim de se estudar fisiopatologia e tratamento dessas doenças. (16,17) Porém, a literatura é escassa e não suficientemente detalhada no que se refere ao estudo do enxerto total de pele humana na bolsa jugal do hamster.…”