Microcirculation in psoriasis: Blood vessels, lymphatics and tissue fluid

Ryan, Terence J.

doi:10.1016/0163-7258(80)90008-x

Cited by 90 publications

(59 citation statements)

References 129 publications

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“…Inflammation also increases lymphatic drainage; lymphangitis may aggravate clinical and experimental inflammation. [62][63][64][65] BEC and LEC differential responses to cytokines might also reflect anatomical or species differences. 66,67 Disturbances in LEC barrier, especially in 18 lymphatics could increase tissue edema.…”

Section: Cytokines Differentially Affect Lymphatic Teermentioning

confidence: 99%

Differential Cytokine Responses in Human and Mouse Lymphatic Endothelial Cells to Cytokinesin Vitro

Chaitanya

Franks

Cromer

et al. 2010

Lymphatic Research and Biology

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Background: Inflammatory cytokines dysregulate microvascular function, yet how cytokines affect lymphatic endothelial cells (LEC) are unclear. Methods and Results: We examined effects of TNF-a, IL-1b, and IFN-g on LEC proliferation, endothelial cell adhesion molecule (ECAM) expression, capillary formation, and barrier changes in murine (SV-LEC) and human LECs (HMEC-1a). Results: All cytokines induced ICAM-1, VCAM-1, MAdCAM-1, and E-selectin in SV-LECs; TNF-a, IL-1b and IFN-g induced ECAMs (but not MAdCAM-1) in HMEC-1a. IL-1b increased, while IFN-g and TNF-a reduced SV-LEC proliferation. While TNF-a induced, IFN-g decreased, and IL-1b did not show any effect on HMEC-1a proliferation. TNF-a, IL-1b, and IFN-g each reduced capillary formation in SV-LEC and in HMEC-1a. TNF-a and IL-1b reduced barrier in SV-LEC and HMEC-1a; IFN-g did not affect SV-LEC barrier, but enhanced HMEC-1a barrier. Inflammatory cytokines alter LEC growth, activation and barrier function in vitro and may disturb lymphatic clearance increasing tissue edema in vivo. Conclusion: Therapies that maintain or restore lymphatic function (including cytokines blockade), may represent important strategies for limiting inflammation.

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Section: Cytokines Differentially Affect Lymphatic Teermentioning

confidence: 99%

Differential Cytokine Responses in Human and Mouse Lymphatic Endothelial Cells to Cytokinesin Vitro

Chaitanya

Franks

Cromer

et al. 2010

Lymphatic Research and Biology

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“…laser Doppler, transcutaneous P02) for the clinical in vivo investigation of cutaneous microcirculation in skin diseases [1, 2, 3]. Its use for the study of the affected skin of inflammatory dermatoses was abandoned because it required specialized units with sophisticated instruments, such as the stereomicroscope or the videomicroscope, and because of the lack of specific vascular findings [4]. In this study, we tested if surface microscopy of common inflammatory dermatoses, such as plaque psoriasis (PP) and lichen planus (LP), can be performed by utilizing a handheld dermoscope.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic Features of Plaque Psoriasis and Lichen Planus: New Observations

et al. 2003

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Background: Dermoscopic features of common inflammatory dermatoses are not well studied and previous reports on this topic are limited to the search of vascular features (capillaroscopy). Objective: Dermoscopic features of psoriasis and lichen planus (LP) are investigated to determine both vascular and nonvascular features of these two dermatoses. Patients and Methods: Dermoscopic images of 25 patients with LP and 20 patients with plaque psoriasis (PP) were evaluated. Findings were statistically analyzed including the reproducibility of scoring (Cohen’s kappa statistics). Results: Our observations clearly showed that the evaluation of both vascular and nonvascular findings improved the surface microscopy of these diseases. A vascular feature (homogeneous red globules) was the most significant dermoscopic finding in the PP dermoscopic pattern (20/20, 100%; p < 0.001). A nonvascular feature (whitish striae) was the most significant dermoscopic feature in the LP pattern (23/25, 92%; p < 0.001). Dermoscopic features of LP also included gray-blue dots, comedo, milium-like cysts, and vascular structures (red lines). The intraobserver and interobserver reproducibility of scoring was very high (k value, 0.9). Conclusion: Our study shows for the first time that the efficacy of surface microscopy of common inflammatory dermatoses may be improved by investigating both vascular and nonvascular findings and its practicability in daily practice by using the dermoscope. Although dermoscopy does not provide clear additional help in the clinical differentiation between typical PP and LP, it could be helpful in patients with darker skin and for teaching settings.

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“…16,17 Additionally, the increased flow should make greater amounts of oxygen available to neutrophils for the oxidative bursts that kill bacteria. 18 Our study showed that in VAC group after day 4, there were 20% of patients who had no bacterial growth, and on day 8 there were 60% of patients who had no bacterial growth, whereas in saline-wet-to-moist patients only 20% of patients had no bacterial growth on the 8th day ( Figure 1). There have been similar studies by Morykwas and Argenta, 7 Banwell et al, 19 and Morykwas et al 20 which showed clearance of bacteria from infected wounds using VAC therapy.…”

Section: Discussionmentioning

confidence: 91%