Keloid heterograft in the hamster (Mesocricetus auratus) cheek pouch

Hochman, Bernardo; Bôas, Flaviane Cássia Vilas; Mariano, Mário; Ferreira, Lydia Masako

doi:10.1590/s0102-86502005000300003

Cited by 26 publications

(16 citation statements)

References 26 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also noted an increase of melanocytes in the groups sacrificed after 42 days. Unfortunately, epithelium integrity was not completely maintained in the groups after 42 days, and the authors suggest that this model may be effective for about 21 days [63]. …”

Section: Experimental Models Of Abnormal Scarringmentioning

confidence: 99%

Models of Abnormal Scarring

Seo

Lee

Jung

2013

BioMed Research International

View full text Add to dashboard Cite

Keloids and hypertrophic scars are thick, raised dermal scars, caused by derailing of the normal scarring process. Extensive research on such abnormal scarring has been done; however, these being refractory disorders specific to humans, it has been difficult to establish a universal animal model. A wide variety of animal models have been used. These include the athymic mouse, rats, rabbits, and pigs. Although these models have provided valuable insight into abnormal scarring, there is currently still no ideal model. This paper reviews the models that have been developed.

show abstract

Section: Experimental Models Of Abnormal Scarringmentioning

confidence: 99%

Models of Abnormal Scarring

Seo

Lee

Jung

2013

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Thus, a better animal model for human scarring is strongly justified. [3][4][5][6] An ideal animal model should match human hypertrophic scarring in clinical appearance, histological aspects, biochemistry, immunology, molecular biology, and clinical behavior.…”

mentioning

confidence: 99%

Is There an Ideal Animal Model to Study Hypertrophic Scarring?

Ramos

Gragnani

Ferreira

2008

Journal of Burn Care & Research

112

View full text Add to dashboard Cite

Wound healing in hypertrophic scarring and keloid animal models presents significant differences when compared with humans. A brief review is presented about hypertrophic scarring in animal models during the last 5 years. Models were described by animals and scientific artifices to cause hypertrophic scarring. They were divided into 1) heterologous hypertrophic scarring or keloid implants in immunodeficient animals (athymic mice and rats); 2) heterologous hypertrophic scarring or keloid implant in immune privileged site (hamster cheek pouch); 3) hypertrophic scarring or keloid induction via chemically mediated injury (guinea pigs); 4) hypertrophic scarring or keloid induction in anatomic specific site (rabbit ear); and the 5) porcine model. The ideal model would allow to research pathophysiology, histology, and molecular events during time and to test prophylactic and therapeutic treatments for humans. Some of these animals were useful to study specific steps of the scarring process and better understand abnormal wound healing, but none of them have a widespread use. Most recently, the female red Duroc pigs were validated as a new model, demonstrating its similarity to human conditions in different ways. Full-thickness human skin grafts in nude mice also represent improvement in the search of an ideal hypertrophic scarring animal model.

show abstract

“…The epithelial wall of the pouch is translucid; this facilitates visualization and helps avoid damage to blood vessels and potential antigenic contact through the blood. After inversion back into the oral cavity, the pouch wall accommodates the graft, protecting it against external trauma, making postoperative bandages unnecessary 13 , despite the risk of trauma associated with food storage.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

Melo

Alves²,

Silva³

et al. 2018

Acta Cir. Bras.

View full text Add to dashboard Cite

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model 1 Abstract Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.

show abstract

Keloid heterograft in the hamster (Mesocricetus auratus) cheek pouch

Abstract: Hamster cheek pouch represents, a priori, an experimental model for the investigation of keloid.

Cited by 26 publications

References 26 publications

Models of Abnormal Scarring

Models of Abnormal Scarring

Is There an Ideal Animal Model to Study Hypertrophic Scarring?

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

Contact Info

Product

Resources

About