Triterpenoids

Mahato, Shashi B.; Nandy, Abhishek; Roy, Gita

doi:10.1016/0031-9422(92)83257-y

Cited by 133 publications

(87 citation statements)

References 340 publications

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“…The characterization of the constituents of the less polar triterpene mixture as well as of the more polar constituents was simplified by the assignment of the carbon atoms in the 13 C NMR. As the chemical shift of a sp 2 carbon atom is very characteristic for each triterpenoid skeleton, 13 C NMR spectroscopy has been very frequently employed for the structural analysis of triterpene mixtures 11 . To distinguish carbon types (multiplicity), the attached proton test (APT) was used.…”

Section: Resultsmentioning

confidence: 99%

Dirhamnosyl flavonoid and other constituents from Brillantaisia palisatii

et al. 2003

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Recebido em 17/7/02; aceito em 10/4/03 DIRHAMNOSYL FLAVONOID AND OTHER CONSTITUENTS FROM Brillantaisia palisatii. A mixture containing sitosterol and stigmasterol; a new triterpene 3-epi-ursolic acid; another triterpene mixture comprising α-amyrin, β-amyrin and lupeol; verbascoside, a phenylpropanoid glycoside; and lespedin, a glycosyl flavonoid, were isolated. The less polar compounds (steroids and triterpenoids) were isolated from the hexane partition of the crude ethanolic extract while the more polar ones (phenylpropanoid glycoside and glycosyl flavonoid) were isolated from the ethyl acetate partition of the same extract. The structures of all compounds were established using modern spectrometric methods of elucidation. The spectroscopic data of Lespedin, a rare dirhamnosylflavonol with hypotensor activity and of the triterpene, 3-epi-ursolic acid, are also reported.

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Section: Resultsmentioning

confidence: 99%

Dirhamnosyl flavonoid and other constituents from Brillantaisia palisatii

et al. 2003

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“…Triterpenóides são constituintes que têm despertado um grande interesse nos últimos anos em razão da descoberta do seu potencial farmacológico, com inúmeras atividades terapêuticas, tais como: anticâncer, antiinfl amatório, antileprótico, antiviral, antibacteriano, antifúngico, antidiurético, giardicida e inibidores da enzima acetilcolinesteras (Mahato et al, 1992;Sen, 1997;Yasukawa;Akihisa, 2000;Amaral et al, 2006;Barbosa-Filho et al, 2006;Barbosa-Filho et al, 2007). Estudos mostrando a relação estrutura química/atividade biológica de triterpenos encontram-se bem representados na literatura, onde modifi cações estruturais são obtidas objetivando a potencialização da ação farmacológica do triterpeno de partida (Kapoor;Chawla, 1986).…”

Section: Introductionunclassified

Obtenção de derivados da mistura triterpenoídica alfa- e beta-amirina

Bandeira¹,

Lemos²,

Costa³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Usando reações clássicas como esterifi cação e oxidação, uma série de derivados foi obtida a partir da mistura α-e β-amirina, constituintes majoritários da resina de Protium heptaphyllum. Os compostos obtidos foram caracterizados por dados espectroscópicos como: IV, RMN de 1 H e de 13 C e comparação com dados da literatura.Unitermos: Protium heptaphyllum, Burseraceae, α-e β-amirina, derivados.ABSTRACT: "Obtention of derivatives from the α-and β-amyrin triterpenoid mixture: 13 C NMR data". Using classic reactions such as esterifi cation and oxidation, a series of derivatives was obtained from the α-and β-amyrin mixture, major compounds of the Protium heptaphyllum resin. The obtained compounds were characterized by spectroscopic data such as: IR, 1 H and 13 C NMR and comparison with literature.

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“…Triterpenoids, which are 30-carbon subsets of terpenoids, serve important functions as steroids in eukaryotes, hopanoids in prokaryotes, and pentacyclic triterpenoids in plants (2). These pentacyclic triterpenoids possess a robust spectrum of structural distinctiveness and biological activities primarily because of wide ranging cyclizations of a single substrate 2,3-oxidosqualene brought about by various members of the oxidosqualene cyclase (OSC) 2 gene family (1).…”

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confidence: 99%

Cloning and Functional Characterization of Three Branch Point Oxidosqualene Cyclases from Withania somnifera (L.) Dunal

Dhar

Rana

Razdan

et al. 2014

Journal of Biological Chemistry

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Background: Pharmacological investigations position withanolides as important bioactive molecules demanding their copious production. Results: Differential transcriptional and translational expression of three oxidosqualene cyclases leads to redirection of metabolic fluxes. Conclusion: Negative regulator channelizes substrate pool toward cycloartenol synthase at subdividing junction leading to enhanced withanolide production. Significance: Understanding the regulatory role of oxidosqualene cyclases on withanolide accumulation could serve as a prognostic tool for metabolic engineering.

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Triterpenoids

Cited by 133 publications

References 340 publications

Dirhamnosyl flavonoid and other constituents from Brillantaisia palisatii

Dirhamnosyl flavonoid and other constituents from Brillantaisia palisatii

Obtenção de derivados da mistura triterpenoídica alfa- e beta-amirina

Cloning and Functional Characterization of Three Branch Point Oxidosqualene Cyclases from Withania somnifera (L.) Dunal

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