Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.
RESUMO:Usando reações clássicas como esterifi cação e oxidação, uma série de derivados foi obtida a partir da mistura α-e β-amirina, constituintes majoritários da resina de Protium heptaphyllum. Os compostos obtidos foram caracterizados por dados espectroscópicos como: IV, RMN de 1 H e de 13 C e comparação com dados da literatura.Unitermos: Protium heptaphyllum, Burseraceae, α-e β-amirina, derivados.ABSTRACT: "Obtention of derivatives from the α-and β-amyrin triterpenoid mixture: 13 C NMR data". Using classic reactions such as esterifi cation and oxidation, a series of derivatives was obtained from the α-and β-amyrin mixture, major compounds of the Protium heptaphyllum resin. The obtained compounds were characterized by spectroscopic data such as: IR, 1 H and 13 C NMR and comparison with literature.
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