Trimester Pattern of Change and Reference Ranges of Hematological Profile Among Sudanese Women with Normal Pregnancy

Rayis, Duria A.; Ahmed, Mohamed A.; Abdel-Moneim, Abdel-Moneim Hafez; Lutfi, Mohamed Faisal

doi:10.4081/cp.2017.888

Cited by 16 publications

(14 citation statements)

References 23 publications

(52 reference statements)

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“…The median MCV and MCH values increase as pregnancy advances from first to third trimesters in this study. This was comparable with the finding reported from Nigeria [ 37 ], and Sudan [ 38 ]. Inconsistent findings were reported from other Nigerian studies [ 39 ], and Ethiopian studies [ 36 ].…”

Section: Discussionsupporting

confidence: 92%

Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia

et al. 2021

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Background Pregnancy is a state characterized by physiological, hematological, and immunological changes. However, the reference intervals (RI) being used in clinical practice in Ethiopia are derived from non-local general populations. Therefore; this study was aimed to determine the reference interval of hematological and immunological profiles among healthy pregnant mothers attending Hawassa University Hospital. Methods A cross-sectional study in a total of 360 healthy pregnant women was enrolled from January to April 2019, at Hawassa University hospital. Sociodemographic and obstetric data were collected using a structured questionnaire. Blood samples collected from each participant were used to define the hematological parameters. The median and 95% intervals were calculated for the immunological and hematological profiles. P-value 0.05 was considered statistically significant. Result A total of 360 healthy pregnant women were enrolled in this study. The age range of the participants was 18–45 years. 342(95%) were married and 270 (75%) of the participants were multigravida. The overall median CD4+ T-cell and total WBC counts (cells/mm3) were 602 and 7.58 respectively. The overall median value for lymphocytes, neutrophils, monocytes, eosinophils, and basophil count was (cells/mm3) was 2.21, 6.74, .63, .53, and 0.09 respectively. Whereas the median RBC and platelet count was 4.48×106/μLand 212×106/μL. The median value of hematological profiles in the first, second, and third trimesters was TWBC (103/μL) (7.90, 8.30, 8.65), RBC (106/μL) (4.5, 4.6, 4.62), and PLT (103/μL) (210, 209,161) respectively. The CD4 T cell count median value was (600, 598, and 591) in the first, second, and third trimesters. Significant changes were observed in hematological and immunological parameters between trimesters (P < 0.05). Conclusion Significant changes were observed in hematological and immunological parameters between trimesters (P < 0.05). Considerable differences were also seen between the values in this study and other studies from Ethiopia and other countries, indicated the need for the development of local reference intervals for pregnant women.

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Section: Discussionsupporting

confidence: 92%

Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia

et al. 2021

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“…The numbers were finally expressed as the number of pigmented cells neutrophils or monocytes /L. Two ml of blood was taken from each participant in an ethylene diamine tetra acetic acid (EDTA) containing tube and immediately analysed for a complete haemogram using an automated haematology analyser (Sysmex XN-9000; Hyogo, Japan) as previously described and following the manufacturer's instructions [15][16][17]. The haemogram included haemoglobin level, leucocyte count and platelet indices, namely platelet count, mean platelet volume (MPV), and platelet distribution width (PDW).…”

Section: Methodsologymentioning

confidence: 99%

Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria

Salih

Eltahir²,

Abdallah

et al. 2018

J Infect Dev Ctries

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Introduction: Haemozoin –containing leucocytes (HCL) can be used to predict severe malaria. Methodology: A case –control study was conducted in Singa, Sudan, to investigate the haematological values and HCL in children with severe Plasmodium falciparum malaria. The cases were children with severe P. falciparum malaria (67). The two groups of controls were patients with uncomplicated P. falciparum malaria (63) and healthy children (50). Results: The mean (±SD) age was 5.5 (±3.8) years. In comparison with children with uncomplicated P. falciparum malaria, children with severe P. falciparum malaria had significantly lower haemoglobin and platelet counts, and significantly higher lymphocyte counts, red cell distribution width (RDW), and platelet distribution width (PDW). The rate of haemozoin –containing monocytes (percentage of children positive for this parameter in each group) was 91.0%, 84.6% and 50.0%, P<0.001 in children with severe P. falciparum, uncomplicated P. falciparum malaria and negative controls, respectively. Receiver Operating Characteristic (ROC) curves for blood parameters and HCL were plotted and the areas under the curve (AUC) were calculated for the prediction of severe P. falciparum malaria infection. The ROC curve analysis, showed a fair predictability of malaria for haemoglobin (AUC = 0.74, sensitivity = 76.0% and specificity = 60.3%, cut-off = 9.7g/dl), lymphocytes (AUC = 0.71, sensitivity = 71.3% and specificity = 62.2%, cut-off = 1.95×103/mm3), PDW (AUC = 0.69, sensitivity = 80.1% and specificity = 66.3%, cut-off = 15.34 %) and haemozoin in the monocytes (AUC = 0.68, sensitivity = 68.2% and specificity = 65.2%, cut-off =5.5 %). Conclusion: RDW, PDW and HCL could be used to predict severe malaria in this setting.

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“…The blood was analyzed for a complete blood count using an automated hematology analyzer and by following the manufacturer’s instructions (Sysmex KX-21; Sysmex Co., Ltd., Kobe, Japan) as previously described. 12 , 13 …”

Section: Methodsmentioning

confidence: 99%

Peripheral hematological parameters in women with polycystic ovary syndrome

ALhabardi

Al‐Wutayd

Eltayieb³

et al. 2020

J Int Med Res

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Objective There have been few studies on hematological parameters (e.g., hemoglobin, red cell distribution width, white blood cells, and mean platelet volume), and polycystic ovary syndrome (PCOS). This study aimed to compare hematological parameters between women with PCOS and controls. Methods We performed an age-matched case–control study in Faisal bin Mishal Center for Infertility, Buraidah (Kingdom of Saudi Arabia). The cases were women with PCOS and an equal number of healthy women were enrolled as controls. The basic gynecological history was recorded and blood samples were analyzed for blood parameters using an automated hematology analyzer. Results The two groups (60 women in each arm of the study) were similar in age. However, body mass index was significantly higher in women with PCOs compared with controls. There were no significant differences in any of the hematological parameters (hemoglobin, red blood cells, red cell distribution width, white blood cells, platelets, and mean platelet volume) between the two groups. Conclusion There does not appear to be a significant difference in hematological parameters in Saudi women with PCOS and healthy controls. A larger study on this issue is required in the future.

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Trimester Pattern of Change and Reference Ranges of Hematological Profile Among Sudanese Women with Normal Pregnancy

Cited by 16 publications

References 23 publications

Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia

Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia

Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria

Peripheral hematological parameters in women with polycystic ovary syndrome

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