Peripheral hematological parameters in women with polycystic ovary syndrome

ALhabardi, Nadiah; Al‐Wutayd, Osama; Eltayieb, Khalid M; Shiha, Yasir S; Al-Shafei, Ahmad I; Adam, Ishag

doi:10.1177/0300060520952282

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The results of this study were consistent with a study which reported that PCOS is the most common endocrine disorder among women between the ages of between (20-40) years .Our results similar to previous study by [13] there were no significant differences in age, residence, and education between the cases and the controls. While our results contradicted with study by [15] which found an association between body mass index and PCO.…”

Section: Discussionsupporting

confidence: 92%

Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women

Hameed,

Khezri,

Khalaf

et al. 2024

IJOIR

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Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder, occurring in young women at reproductive age. This study was carried out to investigate the association between the fat mass and obesity associated gene (Omentin-1V109D gene) polymorphism with some physiological and biochemical Parameters. The present study indicates to the association between PCOS patients and control groups according to the hormonal profile and there is a link between obesity and pathogenesis of hyperprolactinemia, our data showed highly significantly difference. This study shows demonstrated the comparison of the mean of selected Lipid profile between PCOS patients and control group involving (T. Cholesterol, Triglyceride, HDL, LDL and VLDL). The mean value of serum total cholesterol (T.C), Triglyceride, HDL, LDL and VLDL are highly significantly increased (p<0.01) in PCOS patients group compared with healthy group (control). It was found highly significant association (P≤0.01) of serum-FSH, serum-LH, testosterone and prolactin hormones. It was found the mean value of serum total cholesterol, triglyceride, HDL, LDL and VLDL are highly significantly (P≤0.01) increased in PCOS patients. The Omentin gene (V109D rs2274907A) polymorphism have a significant association with hyper LDL, in women with PCO, and may represent as a risk factor for PCOS incidence.

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Section: Discussionsupporting

confidence: 92%

Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women

Hameed,

Khezri,

Khalaf

et al. 2024

IJOIR

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“…Their results showed that RDW at a cut-off value of 12.8 had an odds ratio of 3.1 and a 95% CI (1.25-7.6) to predict clomiphene citrate resistance among lean PCOS patients (18). On the other hand, the Alhabardi study found no significant difference between RDW and other blood indices among the PCOS and healthy controls they examined ; the author suggested that the small sample size and the presence of complex interaction between PCOS etiological factors were responsible for the shortcoming of their results (19). Our results showed significantly higher serum testosterone in PCOS cases, which was positively correlated to RDW.…”

Section: Discussionmentioning

confidence: 94%

Can Red cell distribution width screen for metabolic abnormality in women with Polycystic Ovarian Syndrome?

2022

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Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy in reproductive-age females, accredited to a chronic low-grade inflammatory reaction. Red distribution width (RDW), a parameter of complete blood count, was tested as an inflammatory marker ; higher RDW was linked to metabolic syndrome. We aimed to examine RDW in distinguishing PCOS-related metabolic and hormonal abnormalities. Methods : A case-control study recruited 128 women, divided into PCOS cases (64 / 128) and controls (64 / 128) according to Rotterdam criteria. Body mass index (BMI), estimated complete blood count parameters, hormonal markers (serum follicle-stimulating hormone (FSH), luteinizing hormone, and serum testosterone), and metabolic markers (HOMA-IR, serum high and low-density lipoprotein) were measured. Results showed that RDW was significantly higher in PCOS. HOMA-IR, LDL, testosterone, and LH / FSH were higher in PCOS and strongly correlated with RDW with positive correlations. HDL was elevated and correlated negatively with RDW in PCOS. ROC calculated (13.55) as RDW cut-off value for insulin-resistant with an AUC of 0.95, P < 0.001. In conclusion, a strong and remarkable correlation of RDW with metabolic abnormalities in PCOS cases with 100% sensitivity and specificity, in addition to being quick and inexpensive, makes it a reliable marker for screening for insulin resistance.

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“…Finally, 10 studies without overlapping patients complied with the inclusion criteria, so were selected for the meta-analysis. 19 – 28 A flowchart illustrating the study selection process is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Mean platelet volume and polycystic ovary syndrome: a systematic review and meta-analysis

Li¹,

Zhou

2022

J Int Med Res

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Objective This meta-analysis evaluated the association between the mean platelet volume (MPV) and polycystic ovary syndrome (PCOS). Methods A systematic literature search using PubMed, EMBASE, and Web of Science databases until June 2021 was conducted. Pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were determined using a random effects model. Results Ten studies involving 866 women with PCOS and 548 age- and body mass index-matched women without PCOS were included. The MPV was significantly increased in women with PCOS compared with non-PCOS women (SMD = 0.43, 95% CI = 0.13–0.72). Subgroup analyses showed that this trend was consistent in cross-sectional studies (SMD = 0.44, 95% CI = 0.03–0.86) and in Turkish women (SMD = 0.46, 95% CI = 0.13–0.79). Meta-regression analysis revealed a marginally positive correlation between the MPV and the homoeostasis model assessment of insulin resistance in women with PCOS. The sensitivity analysis showed that the effect estimate was robust and stable, and publication bias was not evidenced in the pooled analysis. Conclusions This meta-analysis revealed that women with PCOS have a significantly increased MPV than women without PCOS, which is probably associated with insulin resistance. INPLASY registration number: INPLASY2021100021.

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Peripheral hematological parameters in women with polycystic ovary syndrome

Cited by 5 publications

References 20 publications

Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women

Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women

Can Red cell distribution width screen for metabolic abnormality in women with Polycystic Ovarian Syndrome?

Mean platelet volume and polycystic ovary syndrome: a systematic review and meta-analysis

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