2003
DOI: 10.1097/00002508-200305000-00002
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Treatment of Pain in Pregnancy

Abstract: Experience in women seeking recovery from opioids and their newborns illustrates that opioids are an effective and safe pharmacological option for the treatment of pain during pregnancy. Controlled studies are needed to expand knowledge in this clinical area.

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Cited by 41 publications
(35 citation statements)
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“…7 Because paracetamol is the safest analgesic for a developing fetus in early gestation, we preferred paracetamol for postoperative analgesia. 15 Pregnancy continued to term and a healthy baby was born.…”
Section: Discussionmentioning
confidence: 99%
“…7 Because paracetamol is the safest analgesic for a developing fetus in early gestation, we preferred paracetamol for postoperative analgesia. 15 Pregnancy continued to term and a healthy baby was born.…”
Section: Discussionmentioning
confidence: 99%
“…25 Estas modificações provocam o retardo na absorção gástrica e o aumento da ligação proteína-drogas no sangue. Devemos ainda levar em consideração que o metabolismo placentário é influenciado pelo tamanho da molécu-la e de sua liposolubilidade, fatores que modulam a quantidade da droga que será efetivamente passada para o feto.…”
Section: Dor E Gravidezunclassified
“…Devemos ainda levar em consideração que o metabolismo placentário é influenciado pelo tamanho da molécu-la e de sua liposolubilidade, fatores que modulam a quantidade da droga que será efetivamente passada para o feto. 25 O uso crônico de aspirina está associado ao aumento da freqüência de aborto. Além disso, durante o primeiro trimestre aumenta o risco de malformações congênitas, como gastroschisis.…”
Section: Dor E Gravidezunclassified
“…Medications used during this period could cross the placenta and reach the fetus, depending on their lipophilicity, molecular size, concentration and metabolic pathway [2]. Therefore, the Food and Drug Administration of the United States (FDA, US) has established stringent regulations regarding the labeling and use of medications during pregnancy [3].…”
Section: Introductionmentioning
confidence: 99%
“…However, case reports and available studies were often confounded by a lack of documentation, records of dosages, duration, and concurrent medications used [2]. Additionally, animal studies may not accurately reflect human risk due to interspecies differences [6].…”
Section: Introductionmentioning
confidence: 99%