Treatment of breast cancer with capped magnetic-NPs induced hyperthermia therapy

Munir, Tariq; Mahmood, Arslan; Fakhar-e-Alam, M.; Imran, Muhammad; Sohail, Amjad; Amin, Nasir; Latif, Sadia; Rasool, Hafiz Ghullam; Shafiq, Fahad; Haider, Ali; Mahmood, K.

doi:10.1016/j.molstruc.2019.06.067

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…The antibiotic medication causes some side effect for living organs. The nanomaterials science is helping out to solve these critical issues very carefully without damaging the internal organs [1,2]. Furthermore, the metal NPs due to unique physical, chemical and biological properties are preferred for biomedical applications (cancer, antibacterial and skin treatment) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

IMPACT OF Ni DOPANT ON OPTICAL AND MAGNETIC PROPERTIES OF ZnO NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

Munir¹,

Mahmood²,

KASHIF³

et al. 2020

JOR

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In this work, Zn1-xNixO NPs with different concentration (x= 0.0, 0.03, 0.06 and 0.09) were synthesized by using co-precipitation method. The present study is related to investigate crystal structure, surface morphology, optical and magnetic behavior of pure and Ni dopant ZnO NPs. The hexagonal wurtzite structure and crystallite size (19.45 to 21.25 nm) was investigated by using XRD analysis.SEM and FTIR used to identify the surface morphology, stretching and vibrational modes of different functional groups (ZnO, OH, CO and H-O-H) attached on the spectrum of Ni dopant ZnO NPs. Moreover, the optical behavior of Ni dopant ZnO NPs was studied by UV-visible spectroscopy which indicates the absorption band of red shift. Finally, VSM analysis illustrated that Ni dopant ZnO NPs shows high magnetization, retentivity and low corecivity as compare to pure ZnO NPs. In an overall assessment the Ni dopant ZnO NPs shows better optical and magnetic properties for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

IMPACT OF Ni DOPANT ON OPTICAL AND MAGNETIC PROPERTIES OF ZnO NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

Munir¹,

Mahmood²,

KASHIF³

et al. 2020

JOR

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“…After injecting the modified nanoparticles into the breast tumor in the mice, the animal models were exposed to a 15 mT magnetic field and frequency of 100 kHz for one hour. The histological analysis indicated that the AMF caused apoptosis of the cancer cells in the tumor [65]. Cędrowska et al reported a novel conjugation of trastuzumab monoclonal antibody (Herceptin commercial drug) on SPIONs using 3-phosphonopropionic acid (CEPA) and Actinium-225 isotope as an emitter.…”

Section: Computerized Tomography (Ct)mentioning

confidence: 99%

Applications of Iron Oxide Nanoparticles against Breast Cancer

Hosseinkazemi

Samani

O’Neill

et al. 2022

Journal of Nanomaterials

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Breast cancer is the most common cancer diagnosed in women, with an estimated 12% of women in the United States affected during their lifetime. Researchers have demonstrated that early detection, diagnosis, and treatment are pivotal to increasing survival. The advent of nanotechnology has yielded several novel advances and available modern methods within the clinic to detect and treat breast cancer. Inorganic nanoparticles are broadly utilized for cancer diagnosis and therapeutic purposes. Interestingly, these nanoparticles can also be attached to tumor-specific ligands and used to deliver chemotherapeutic or hormonal agents with high levels of tumor selectivity. Iron oxide nanoparticles are one of the most commonly used nanomaterials, which have attracted much attention to detect and treat breast cancers, owing to their superparamagnetic characteristics. Computerized tomography and magnetic resonance imaging (MRI) utilizing iron-based magnetic nanoparticles are promising approaches for the radiological detection of breast cancer. Here, we discuss the roles and recent applications of iron oxide nanoparticles in diagnosing and treating breast cancer.

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“…Despite this, cubic SPIONs are more effective in hyperthermia [ 63 ]. This was proved in vitro [ 144 ] reaching local temperatures of 48 °C (after 1 h treatment at 15 mT and 150 kHz) and effectively killing breast cancer cells [ 145 ]. A high surface absorption rate can be obtained by increasing the frequency of the magnetic field, but that can only be done in a biologically safe limit, determined by Brezovich and Atkinson [ 146 – 147 ] as H · f ≤ C , with C = 5·10 9 A·m −1 ·s −1 .…”

Section: Reviewmentioning

confidence: 99%

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

Suciu¹,

Ionescu²,

Ciorîță³

et al. 2020

Beilstein J. Nanotechnol.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter-patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and therapeutic efficacy, and safety studies.

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Treatment of breast cancer with capped magnetic-NPs induced hyperthermia therapy

Cited by 26 publications

References 24 publications

IMPACT OF Ni DOPANT ON OPTICAL AND MAGNETIC PROPERTIES OF ZnO NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

IMPACT OF Ni DOPANT ON OPTICAL AND MAGNETIC PROPERTIES OF ZnO NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

Applications of Iron Oxide Nanoparticles against Breast Cancer

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

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