Applications of Iron Oxide Nanoparticles against Breast Cancer

Hosseinkazemi, Hessam; Samani, Saeed; O’Neill, Andrew; Soezi, Mahdieh; Moghoofei, Mohsen; Azhdari, Mohammad H.; Aavani, Farzaneh; Nazbar, Abolfazl; Keshel, Saeed Heidari; Doroudian, Mohammad

doi:10.1155/2022/6493458

Cited by 21 publications

(4 citation statements)

References 123 publications

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“…Vaccination is the most successful way to prevent and control disease, and it has saved countless lives in both infectious disease and cancer treatment [5,22,23]. At present, nucleic acid vaccines are divided into two categories: plasmid DNA vaccines and mRNA vaccines, both of which have demonstrated potential [22].…”

Section: Mrna Vaccination and Mechanism Of Action Of Mrnamentioning

confidence: 99%

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

et al. 2023

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In recent years, there has been an increase in deaths due to infectious diseases, most notably in the context of viral respiratory pathogens. Consequently, the focus has shifted in the search for new therapies, with attention being drawn to the use of nanoparticles in mRNA vaccines for targeted delivery to improve the efficacy of these vaccines. Notably, mRNA vaccine technologies denote as a new era in vaccination due to their rapid, potentially inexpensive, and scalable development. Although they do not pose a risk of integration into the genome and are not produced from infectious elements, they do pose challenges, including exposing naked mRNAs to extracellular endonucleases. Therefore, with the development of nanotechnology, we can further improve their efficacy. Nanoparticles, with their nanometer dimensions, move more freely in the body and, due to their small size, have unique physical and chemical properties. The best candidates for vaccine mRNA transfer are lipid nanoparticles (LNPs), which are stable and biocompatible and contain four components: cationic lipids, ionizable lipids, polyethylene glycols (PEGs), and cholesterol, which are used to facilitate cytoplasmic mRNA delivery. In this article, the components and delivery system of mRNA-LNP vaccines against viral lung infections such as influenza, coronavirus, and respiratory syncytial virus are reviewed. Moreover, we provide a succinct overview of current challenges and potential future directions in the field.

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Section: Mrna Vaccination and Mechanism Of Action Of Mrnamentioning

confidence: 99%

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

et al. 2023

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“…Nanoscale devices and materials can deliver therapeutic drugs specifically to cancer cells, thereby reducing exposure to healthy tissues. [6,7] Nanoparticles (NPs) show particular promise in the treatment of lung cancer, where they can be utilized as drug delivery systems. Incorporating therapeutics that specifically target cancer cells into NPs has shown to be more effective for treatment with fewer side effects.…”

Section: Doi: 101002/adtp202300275mentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.

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“…Inorganic formats of nucleic acid delivery, such as gold nanoparticles, carbon nanotubes, and graphene, also produce significant performance. Protein and other biomolecules can also be delivered using chemical transfection ( He et al, 2020 ; Hosseinkazemi et al, 2022 ). Polymeric carriers are chemically diverse and versatile.…”

Section: Non-viral Nano Delivery Systemsmentioning

confidence: 99%

Nanocarriers: A novel strategy for the delivery of CRISPR/Cas systems

et al. 2022

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In recent decades, clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) has become one of the most promising genome-editing tools for therapeutic purposes in biomedical and medical applications. Although the CRISPR/Cas system has truly revolutionized the era of genome editing, the safe and effective delivery of CRISPR/Cas systems represents a substantial challenge that must be tackled to enable the next generation of genetic therapies. In addition, there are some challenges in the in vivo delivery to the targeted cells/tissues. Nanotechnology-based drug delivery systems can be employed to overcome this issue. This review discusses different types and forms of CRISPR/Cas systems and the current CRISPR/Cas delivery systems, including non-viral carriers such as liposomes, polymeric, and gold particles. The focus then turns to the viral nanocarriers which have been recently used as a nanocarrier for CRISPR/Cas delivery.

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Applications of Iron Oxide Nanoparticles against Breast Cancer

Cited by 21 publications

References 123 publications

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Nanocarriers: A novel strategy for the delivery of CRISPR/Cas systems

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